Single cell type - TMEM159 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM159
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 159
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Squamous epithelial cells - Keratinization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal squamous epithelial cells, Suprabasal keratinocytes, Squamous epithelial cells, Basal keratinocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal squamous epithelial cells, Suprabasal keratinocytes, Squamous epithelial cells, Basal keratinocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TMEM159 is part of cluster 61 Squamous epithelial cells - Keratinization with confidenceⁱ 1
176 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
IRX4	Iroquois homeobox 4	0.6850	61
CBR3	Carbonyl reductase 3	0.6749	61
S100A14	S100 calcium binding protein A14	0.6707	61
SOX15	SRY-box transcription factor 15	0.6605	61
KRT5	Keratin 5	0.6505	61
CAPNS2	Calpain small subunit 2	0.6459	61
LY6G6D	Lymphocyte antigen 6 family member G6D	0.6431	61
PKP1	Plakophilin 1	0.6368	61
GSDMC	Gasdermin C	0.6254	61
LY6D	Lymphocyte antigen 6 family member D	0.6254	61
SLURP1	Secreted LY6/PLAUR domain containing 1	0.6176	61
PPL	Periplakin	0.6133	61
DSC3	Desmocollin 3	0.6119	61
DSG3	Desmoglein 3	0.6117	61
GRHL3	Grainyhead like transcription factor 3	0.6065	61

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.3 nTPM
Adipose tissue	17.5 nTPM
Breast	17.1 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	20.9 nTPM
Lung	20.9 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	12.9 nTPM
Adipose tissue	22.5 nTPM
PBMC	15.7 nTPM
Lymph node	15.6 nTPM
Spleen	14.9 nTPM
Bone marrow	14.7 nTPM
Stomach	14.5 nTPM
Colon	14.4 nTPM
Breast	10.7 nTPM
Liver	5.5 nTPM
Kidney	0.0 nTPM

Basal squamous epithelial cells	176.4 nTPM
Esophagus	176.4 nTPM

Dendritic cells	9.1 nTPM
Breast	12.4 nTPM
Adipose tissue	10.9 nTPM
PBMC	4.0 nTPM

Endothelial cells	13.7 nTPM
Skin	29.2 nTPM
Breast	27.2 nTPM
Liver	21.1 nTPM
Heart muscle	20.8 nTPM
Esophagus	18.6 nTPM
Prostate	17.8 nTPM
Skeletal muscle	17.2 nTPM
Testis	14.9 nTPM
Endometrium	8.9 nTPM
Eye	6.5 nTPM
Ovary	4.7 nTPM
Pancreas	3.9 nTPM
Placenta	1.7 nTPM
Lung	0.0 nTPM

Fibroblasts	44.3 nTPM
Adipose tissue	121.2 nTPM
Skin	91.6 nTPM
Esophagus	56.4 nTPM
Skeletal muscle	55.6 nTPM
Breast	45.8 nTPM
Lung	40.2 nTPM
Prostate	21.3 nTPM
Heart muscle	19.3 nTPM
Ovary	13.6 nTPM
Placenta	12.8 nTPM
Stomach	8.9 nTPM

Intestinal goblet cells	30.6 nTPM
Rectum	45.3 nTPM
Colon	27.9 nTPM
Small intestine	18.5 nTPM

Macrophages	13.8 nTPM
Prostate	21.8 nTPM
Esophagus	20.4 nTPM
Testis	19.7 nTPM
Adipose tissue	17.8 nTPM
Ovary	16.6 nTPM
PBMC	13.6 nTPM
Pancreas	12.8 nTPM
Endometrium	12.7 nTPM
Skeletal muscle	12.5 nTPM
Lung	12.4 nTPM
Breast	11.2 nTPM
Bone marrow	10.0 nTPM
Stomach	8.8 nTPM
Kidney	8.3 nTPM
Spleen	8.3 nTPM

Paneth cells	41.8 nTPM
Colon	69.2 nTPM
Rectum	44.9 nTPM
Small intestine	11.3 nTPM

Plasma cells	3.8 nTPM
Adipose tissue	14.2 nTPM
Spleen	1.9 nTPM
Bone marrow	1.7 nTPM
Stomach	1.5 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	11.2 nTPM
Bronchus	18.0 nTPM
Lung	4.4 nTPM

Smooth muscle cells	35.7 nTPM
Adipose tissue	77.9 nTPM
Skin	65.2 nTPM
Breast	57.8 nTPM
Esophagus	57.4 nTPM
Prostate	36.2 nTPM
Skeletal muscle	29.6 nTPM
Heart muscle	24.0 nTPM
Endometrium	18.7 nTPM
Ovary	15.4 nTPM
Pancreas	8.1 nTPM
Bronchus	2.8 nTPM

Collecting duct cells	22.0 nTPM
Kidney	22.0 nTPM

Cytotrophoblasts	4.8 nTPM
Placenta	4.8 nTPM

Distal enterocytes	34.5 nTPM
Rectum	37.2 nTPM
Colon	31.7 nTPM

Distal tubular cells	7.9 nTPM
Kidney	7.9 nTPM

T-cells	14.8 nTPM
Skin	36.4 nTPM
Lymph node	20.0 nTPM
Adipose tissue	19.6 nTPM
Ovary	17.8 nTPM
PBMC	14.9 nTPM
Spleen	14.3 nTPM
Esophagus	13.1 nTPM
Stomach	13.0 nTPM
Breast	13.0 nTPM
Colon	12.8 nTPM
Skeletal muscle	12.4 nTPM
Bone marrow	12.4 nTPM
Liver	11.6 nTPM
Lung	10.6 nTPM
Endometrium	10.4 nTPM
Kidney	9.6 nTPM
Prostate	9.5 nTPM

Undifferentiated cells	29.9 nTPM
Rectum	32.5 nTPM
Colon	30.4 nTPM
Small intestine	26.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC