Single cell type - XYLT2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	XYLT2
Gene descriptionⁱ Full gene name according to HGNC.	Xylosyltransferase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Early spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Early spermatids, Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Early spermatids, Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

XYLT2 is part of cluster 29 Early spermatids - Spermatogenesis with confidenceⁱ 1
337 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CCDC185	Coiled-coil domain containing 185	0.8940	29
CCIN	Calicin	0.8814	29
WFDC11	WAP four-disulfide core domain 11	0.8813	29
DNAJB7	DnaJ heat shock protein family (Hsp40) member B7	0.8812	29
C10orf120	Chromosome 10 open reading frame 120	0.8774	29
FAM170B	Family with sequence similarity 170 member B	0.8740	29
OR2H2	Olfactory receptor family 2 subfamily H member 2	0.8650	29
LRRC72	Leucine rich repeat containing 72	0.8646	29
CALR3	Calreticulin 3	0.8638	29
ASB17	Ankyrin repeat and SOCS box containing 17	0.8621	29
C2orf16	Chromosome 2 open reading frame 16	0.8585	29
SPATA31E1	SPATA31 subfamily E member 1	0.8542	29
C20orf173	Chromosome 20 open reading frame 173	0.8492	29
SRRM5	Serine/arginine repetitive matrix 5	0.8486	29
TEKT5	Tektin 5	0.8482	29

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	7.5 nTPM
Adipose tissue	8.2 nTPM
Breast	6.9 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	6.1 nTPM
Lung	6.1 nTPM

Astrocytes	13.1 nTPM
Brain	13.1 nTPM

B-cells	3.9 nTPM
Breast	5.3 nTPM
Liver	5.0 nTPM
Colon	4.8 nTPM
Kidney	4.8 nTPM
Lymph node	4.5 nTPM
Spleen	4.2 nTPM
Stomach	3.7 nTPM
PBMC	2.8 nTPM
Bone marrow	2.5 nTPM
Adipose tissue	1.5 nTPM

Dendritic cells	3.8 nTPM
Breast	6.5 nTPM
Adipose tissue	5.0 nTPM
PBMC	0.0 nTPM

Endothelial cells	6.8 nTPM
Heart muscle	16.0 nTPM
Testis	11.6 nTPM
Skin	8.2 nTPM
Placenta	8.0 nTPM
Endometrium	7.9 nTPM
Liver	7.3 nTPM
Skeletal muscle	6.9 nTPM
Ovary	6.4 nTPM
Lung	6.2 nTPM
Eye	5.7 nTPM
Pancreas	3.9 nTPM
Breast	3.9 nTPM
Esophagus	2.6 nTPM
Prostate	1.0 nTPM

Fibroblasts	9.1 nTPM
Placenta	17.5 nTPM
Adipose tissue	17.0 nTPM
Skeletal muscle	11.7 nTPM
Skin	11.4 nTPM
Breast	10.7 nTPM
Ovary	10.1 nTPM
Heart muscle	9.0 nTPM
Esophagus	5.9 nTPM
Stomach	4.4 nTPM
Prostate	2.7 nTPM
Lung	0.0 nTPM

Intestinal goblet cells	9.4 nTPM
Rectum	19.0 nTPM
Colon	5.8 nTPM
Small intestine	3.5 nTPM

Macrophages	3.8 nTPM
PBMC	13.6 nTPM
Endometrium	6.2 nTPM
Testis	5.8 nTPM
Pancreas	5.1 nTPM
Lung	4.3 nTPM
Ovary	4.0 nTPM
Skeletal muscle	3.8 nTPM
Breast	3.3 nTPM
Esophagus	3.1 nTPM
Bone marrow	2.5 nTPM
Adipose tissue	2.4 nTPM
Prostate	1.2 nTPM
Spleen	1.0 nTPM
Kidney	0.8 nTPM
Stomach	0.0 nTPM

Paneth cells	3.5 nTPM
Rectum	10.4 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	4.7 nTPM
Bone marrow	6.6 nTPM
Esophagus	6.1 nTPM
Adipose tissue	5.2 nTPM
Stomach	3.8 nTPM
Spleen	1.6 nTPM

Respiratory ciliated cells	3.2 nTPM
Bronchus	6.5 nTPM
Lung	0.0 nTPM

Smooth muscle cells	6.7 nTPM
Adipose tissue	11.8 nTPM
Pancreas	9.8 nTPM
Heart muscle	8.7 nTPM
Endometrium	8.7 nTPM
Skin	7.7 nTPM
Breast	7.5 nTPM
Skeletal muscle	7.3 nTPM
Ovary	5.3 nTPM
Esophagus	4.6 nTPM
Prostate	1.5 nTPM
Bronchus	1.0 nTPM

T-cells	4.8 nTPM
Liver	9.7 nTPM
Skeletal muscle	8.2 nTPM
Breast	8.0 nTPM
Endometrium	6.5 nTPM
Lymph node	6.5 nTPM
Stomach	6.1 nTPM
PBMC	5.9 nTPM
Bone marrow	5.1 nTPM
Spleen	4.7 nTPM
Adipose tissue	4.5 nTPM
Skin	4.1 nTPM
Colon	3.3 nTPM
Lung	3.0 nTPM
Kidney	2.7 nTPM
Ovary	2.2 nTPM
Prostate	0.0 nTPM
Esophagus	0.0 nTPM

Cholangiocytes	10.0 nTPM
Liver	10.0 nTPM

Collecting duct cells	1.8 nTPM
Kidney	1.8 nTPM

Cone photoreceptor cells	29.2 nTPM
Eye	29.2 nTPM

Cytotrophoblasts	7.0 nTPM
Placenta	7.0 nTPM

Undifferentiated cells	11.1 nTPM
Rectum	17.0 nTPM
Colon	11.8 nTPM
Small intestine	4.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC