Single cell type - PHLDB1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PHLDB1
Gene descriptionⁱ Full gene name according to HGNC.	Pleckstrin homology like domain family B member 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Stromal cells - Cell proliferation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Late spermatids, Endometrial stromal cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff, ASC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Late spermatids, Endometrial stromal cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PHLDB1 is part of cluster 36 Stromal cells - Cell proliferation with confidenceⁱ 1
96 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GXYLT2	Glucoside xylosyltransferase 2	0.6719	50
PLEKHH2	Pleckstrin homology, MyTH4 and FERM domain containing H2	0.5782	36
PRRX1	Paired related homeobox 1	0.5463	50
S1PR3	Sphingosine-1-phosphate receptor 3	0.5228	48
WNT5A	Wnt family member 5A	0.5126	36
APCDD1	APC down-regulated 1	0.5102	36
ANKRD13B	Ankyrin repeat domain 13B	0.5083	36
NID1	Nidogen 1	0.4944	36
PKD2	Polycystin 2, transient receptor potential cation channel	0.4930	8
DEFB124	Defensin beta 124	0.4883	36
PTK7	Protein tyrosine kinase 7 (inactive)	0.4878	29
HOXA10	Homeobox A10	0.4853	36
STK3	Serine/threonine kinase 3	0.4840	64
ALDH1A2	Aldehyde dehydrogenase 1 family member A2	0.4829	36
ITPRIPL2	ITPRIP like 2	0.4812	36

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	34.4 nTPM
Adipose tissue	35.5 nTPM
Breast	33.3 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	13.7 nTPM
Lung	13.7 nTPM

Astrocytes	53.2 nTPM
Brain	53.2 nTPM

B-cells	1.6 nTPM
Colon	4.8 nTPM
Breast	2.6 nTPM
Adipose tissue	2.5 nTPM
Stomach	1.8 nTPM
Spleen	1.7 nTPM
Lymph node	1.2 nTPM
Liver	0.9 nTPM
Bone marrow	0.8 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM

Dendritic cells	2.5 nTPM
Breast	5.1 nTPM
Adipose tissue	2.5 nTPM
PBMC	0.0 nTPM

Endothelial cells	32.1 nTPM
Eye	70.4 nTPM
Ovary	58.7 nTPM
Skeletal muscle	56.0 nTPM
Endometrium	36.8 nTPM
Placenta	32.9 nTPM
Skin	31.3 nTPM
Prostate	30.3 nTPM
Pancreas	27.0 nTPM
Liver	25.7 nTPM
Breast	23.8 nTPM
Esophagus	20.2 nTPM
Lung	15.6 nTPM
Heart muscle	11.9 nTPM
Testis	8.9 nTPM

Fibroblasts	54.9 nTPM
Skeletal muscle	84.5 nTPM
Stomach	83.2 nTPM
Adipose tissue	74.9 nTPM
Prostate	72.4 nTPM
Esophagus	63.9 nTPM
Skin	61.1 nTPM
Breast	54.8 nTPM
Lung	35.7 nTPM
Ovary	29.1 nTPM
Placenta	25.3 nTPM
Heart muscle	19.2 nTPM

Intestinal goblet cells	20.4 nTPM
Rectum	26.6 nTPM
Small intestine	18.2 nTPM
Colon	16.5 nTPM

Macrophages	8.2 nTPM
Skeletal muscle	31.3 nTPM
Adipose tissue	17.5 nTPM
Stomach	14.7 nTPM
Prostate	12.6 nTPM
Endometrium	10.6 nTPM
Breast	9.3 nTPM
Lung	8.6 nTPM
Esophagus	7.9 nTPM
Spleen	5.2 nTPM
Testis	2.9 nTPM
Ovary	2.3 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM

Paneth cells	29.8 nTPM
Rectum	39.7 nTPM
Small intestine	30.0 nTPM
Colon	19.7 nTPM

Plasma cells	0.7 nTPM
Adipose tissue	3.3 nTPM
Stomach	0.4 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	0.5 nTPM
Bronchus	1.0 nTPM
Lung	0.0 nTPM

Smooth muscle cells	53.8 nTPM
Skeletal muscle	94.6 nTPM
Adipose tissue	92.1 nTPM
Esophagus	77.6 nTPM
Endometrium	59.9 nTPM
Prostate	56.6 nTPM
Skin	56.1 nTPM
Pancreas	52.8 nTPM
Ovary	48.5 nTPM
Breast	41.3 nTPM
Heart muscle	11.2 nTPM
Bronchus	1.0 nTPM

T-cells	5.4 nTPM
Skin	25.7 nTPM
Breast	8.9 nTPM
Colon	8.1 nTPM
Endometrium	7.9 nTPM
Esophagus	6.6 nTPM
Skeletal muscle	6.5 nTPM
Adipose tissue	5.7 nTPM
Lymph node	5.5 nTPM
Prostate	4.7 nTPM
Spleen	3.6 nTPM
Kidney	2.7 nTPM
Liver	2.0 nTPM
PBMC	1.7 nTPM
Lung	1.5 nTPM
Stomach	0.9 nTPM
Bone marrow	0.4 nTPM
Ovary	0.0 nTPM

Basal keratinocytes	18.4 nTPM
Skin	18.4 nTPM

Basal prostatic cells	9.2 nTPM
Prostate	9.2 nTPM

Basal squamous epithelial cells	14.2 nTPM
Esophagus	14.2 nTPM

Distal enterocytes	34.2 nTPM
Rectum	43.3 nTPM
Colon	25.0 nTPM

Undifferentiated cells	16.8 nTPM
Rectum	28.0 nTPM
Colon	14.5 nTPM
Small intestine	8.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC