Single cell type - NDUFS1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFS1
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase core subunit S1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cardiomyocytes - Muscle contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Cardiomyocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Cardiomyocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NDUFS1 is part of cluster 54 Cardiomyocytes - Muscle contraction with confidenceⁱ 1
250 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ATP2A2	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	0.7837	54
MFN2	Mitofusin 2	0.7821	54
TECRL	Trans-2,3-enoyl-CoA reductase like	0.7788	54
MYOZ2	Myozenin 2	0.7767	54
ANKRD1	Ankyrin repeat domain 1	0.7722	54
TNNT2	Troponin T2, cardiac type	0.7719	54
HRC	Histidine rich calcium binding protein	0.7714	54
STYXL2	Serine/threonine/tyrosine interacting like 2	0.7712	54
CKMT2	Creatine kinase, mitochondrial 2	0.7653	54
FITM2	Fat storage inducing transmembrane protein 2	0.7608	54
COX7A1	Cytochrome c oxidase subunit 7A1	0.7604	54
ITGB1BP2	Integrin subunit beta 1 binding protein 2	0.7537	54
MYH7	Myosin heavy chain 7	0.7509	54
CDIN1	CDAN1 interacting nuclease 1	0.7508	54
ACTC1	Actin alpha cardiac muscle 1	0.7499	54

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	32.4 nTPM
Adipose tissue	39.8 nTPM
Breast	25.0 nTPM

Alveolar cells type 1	60.9 nTPM
Lung	60.9 nTPM

Alveolar cells type 2	33.0 nTPM
Lung	33.0 nTPM

Astrocytes	45.1 nTPM
Brain	45.1 nTPM

B-cells	23.8 nTPM
Liver	37.6 nTPM
PBMC	28.5 nTPM
Adipose tissue	28.5 nTPM
Spleen	27.6 nTPM
Lymph node	26.6 nTPM
Stomach	25.9 nTPM
Bone marrow	23.7 nTPM
Kidney	14.3 nTPM
Colon	12.8 nTPM
Breast	12.1 nTPM

Dendritic cells	18.8 nTPM
Adipose tissue	23.9 nTPM
Breast	16.4 nTPM
PBMC	16.0 nTPM

Endothelial cells	36.6 nTPM
Heart muscle	106.0 nTPM
Pancreas	50.2 nTPM
Eye	45.3 nTPM
Skeletal muscle	42.5 nTPM
Lung	40.6 nTPM
Ovary	40.1 nTPM
Endometrium	34.6 nTPM
Testis	28.5 nTPM
Liver	26.6 nTPM
Esophagus	25.3 nTPM
Placenta	24.5 nTPM
Prostate	17.8 nTPM
Breast	16.5 nTPM
Skin	14.5 nTPM

Fibroblasts	42.3 nTPM
Heart muscle	153.2 nTPM
Skeletal muscle	49.0 nTPM
Adipose tissue	46.9 nTPM
Esophagus	35.0 nTPM
Ovary	34.1 nTPM
Stomach	32.7 nTPM
Placenta	28.4 nTPM
Lung	27.9 nTPM
Breast	20.9 nTPM
Skin	19.4 nTPM
Prostate	17.9 nTPM

Intestinal goblet cells	47.9 nTPM
Rectum	66.1 nTPM
Small intestine	39.7 nTPM
Colon	37.8 nTPM

Macrophages	27.7 nTPM
Pancreas	46.0 nTPM
Lung	43.2 nTPM
Ovary	36.7 nTPM
Skeletal muscle	34.8 nTPM
Bone marrow	32.4 nTPM
Adipose tissue	30.4 nTPM
Spleen	30.0 nTPM
Stomach	29.4 nTPM
Kidney	28.7 nTPM
Testis	26.7 nTPM
Esophagus	25.2 nTPM
Endometrium	23.2 nTPM
Breast	15.4 nTPM
Prostate	13.8 nTPM
PBMC	0.0 nTPM

Paneth cells	46.4 nTPM
Rectum	72.1 nTPM
Small intestine	37.6 nTPM
Colon	29.6 nTPM

Plasma cells	31.0 nTPM
Spleen	48.5 nTPM
Stomach	36.9 nTPM
Bone marrow	34.6 nTPM
Adipose tissue	29.1 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	53.5 nTPM
Lung	65.6 nTPM
Bronchus	41.4 nTPM

Smooth muscle cells	60.8 nTPM
Heart muscle	141.5 nTPM
Bronchus	123.5 nTPM
Skeletal muscle	73.0 nTPM
Adipose tissue	67.7 nTPM
Esophagus	51.2 nTPM
Pancreas	45.1 nTPM
Endometrium	45.0 nTPM
Ovary	36.2 nTPM
Prostate	31.2 nTPM
Breast	28.2 nTPM
Skin	26.5 nTPM

T-cells	23.7 nTPM
Ovary	35.6 nTPM
Lymph node	34.5 nTPM
Esophagus	32.8 nTPM
Skeletal muscle	31.6 nTPM
Stomach	30.0 nTPM
Endometrium	26.1 nTPM
PBMC	26.0 nTPM
Adipose tissue	25.8 nTPM
Kidney	23.3 nTPM
Spleen	23.3 nTPM
Bone marrow	22.9 nTPM
Liver	21.5 nTPM
Lung	19.7 nTPM
Colon	18.1 nTPM
Breast	16.3 nTPM
Skin	16.1 nTPM
Prostate	0.0 nTPM

Basal keratinocytes	16.2 nTPM
Skin	16.2 nTPM

Basal prostatic cells	21.7 nTPM
Prostate	21.7 nTPM

Basal respiratory cells	40.8 nTPM
Bronchus	40.8 nTPM

Basal squamous epithelial cells	30.1 nTPM
Esophagus	30.1 nTPM

Undifferentiated cells	69.9 nTPM
Rectum	86.9 nTPM
Colon	67.2 nTPM
Small intestine	55.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC