Single cell type - TYMP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TYMP
Gene descriptionⁱ Full gene name according to HGNC.	Thymidine phosphorylase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Monocytes - Immune response regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (monocytes, Exocrine glandular cells, Macrophages, Hofbauer cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (classical monocyte, neutrophil, intermediate monocyte, non-classical monocyte, eosinophil, myeloid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CAPAN-2, HHSteC, Karpas-707, U-266/70)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (monocytes, Exocrine glandular cells, Macrophages, Hofbauer cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TYMP is part of cluster 3 Monocytes - Immune response regulation with confidenceⁱ 1
114 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CD86	CD86 molecule	0.8720	3
CD80	CD80 molecule	0.8429	3
IL12B	Interleukin 12B	0.8238	3
IL4I1	Interleukin 4 induced 1	0.8170	3
CCL17	C-C motif chemokine ligand 17	0.8144	3
CCL22	C-C motif chemokine ligand 22	0.8122	3
DBNL	Drebrin like	0.8091	3
FOXD4L1	Forkhead box D4 like 1	0.7924	3
IRF5	Interferon regulatory factor 5	0.7812	3
IDO1	Indoleamine 2,3-dioxygenase 1	0.7775	3
NCCRP1	NCCRP1, F-box associated domain containing	0.7735	3
LSP1	Lymphocyte specific protein 1	0.7734	3
CRLF2	Cytokine receptor like factor 2	0.7561	3
CCR7	C-C motif chemokine receptor 7	0.7448	3
TRAF1	TNF receptor associated factor 1	0.7396	3

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	122.6 nTPM
Breast	137.2 nTPM
Adipose tissue	108.0 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	29.0 nTPM
Lung	29.0 nTPM

Astrocytes	0.3 nTPM
Brain	0.3 nTPM

B-cells	122.9 nTPM
Colon	381.8 nTPM
Breast	227.4 nTPM
Adipose tissue	98.3 nTPM
Liver	97.7 nTPM
PBMC	88.5 nTPM
Spleen	87.6 nTPM
Kidney	76.1 nTPM
Bone marrow	65.4 nTPM
Stomach	58.2 nTPM
Lymph node	48.2 nTPM

Dendritic cells	65.8 nTPM
PBMC	123.5 nTPM
Breast	46.3 nTPM
Adipose tissue	27.7 nTPM

Endothelial cells	55.7 nTPM
Skeletal muscle	134.3 nTPM
Skin	107.9 nTPM
Breast	95.3 nTPM
Eye	93.1 nTPM
Prostate	70.1 nTPM
Pancreas	57.9 nTPM
Esophagus	49.9 nTPM
Liver	46.7 nTPM
Heart muscle	37.3 nTPM
Ovary	24.3 nTPM
Testis	19.8 nTPM
Placenta	18.8 nTPM
Endometrium	15.5 nTPM
Lung	9.3 nTPM

Fibroblasts	81.9 nTPM
Skin	187.0 nTPM
Adipose tissue	148.1 nTPM
Placenta	106.5 nTPM
Breast	104.6 nTPM
Skeletal muscle	98.2 nTPM
Stomach	77.2 nTPM
Prostate	76.1 nTPM
Esophagus	62.1 nTPM
Lung	25.7 nTPM
Heart muscle	10.1 nTPM
Ovary	5.4 nTPM

Intestinal goblet cells	50.2 nTPM
Colon	83.6 nTPM
Small intestine	39.4 nTPM
Rectum	27.5 nTPM

Macrophages	561.7 nTPM
Pancreas	1309.4 nTPM
Kidney	1175.3 nTPM
Spleen	670.8 nTPM
Ovary	597.7 nTPM
Bone marrow	582.2 nTPM
Adipose tissue	581.2 nTPM
Stomach	580.1 nTPM
Prostate	538.7 nTPM
Testis	523.4 nTPM
Skeletal muscle	495.1 nTPM
Endometrium	441.8 nTPM
Breast	428.0 nTPM
Esophagus	228.2 nTPM
PBMC	163.7 nTPM
Lung	109.9 nTPM

Paneth cells	86.4 nTPM
Colon	128.4 nTPM
Small intestine	101.4 nTPM
Rectum	29.3 nTPM

Plasma cells	102.1 nTPM
Stomach	151.2 nTPM
Adipose tissue	149.0 nTPM
Spleen	78.4 nTPM
Esophagus	67.8 nTPM
Bone marrow	64.2 nTPM

Respiratory ciliated cells	78.0 nTPM
Bronchus	132.6 nTPM
Lung	23.3 nTPM

Smooth muscle cells	62.4 nTPM
Pancreas	205.5 nTPM
Skin	83.9 nTPM
Breast	74.1 nTPM
Adipose tissue	68.2 nTPM
Bronchus	63.2 nTPM
Skeletal muscle	51.1 nTPM
Prostate	49.7 nTPM
Endometrium	33.0 nTPM
Esophagus	31.0 nTPM
Ovary	18.3 nTPM
Heart muscle	8.7 nTPM

T-cells	62.5 nTPM
Skin	127.1 nTPM
Prostate	108.9 nTPM
Colon	103.6 nTPM
Breast	77.1 nTPM
PBMC	68.4 nTPM
Ovary	64.5 nTPM
Adipose tissue	58.2 nTPM
Stomach	57.2 nTPM
Spleen	55.9 nTPM
Skeletal muscle	53.0 nTPM
Kidney	50.7 nTPM
Bone marrow	46.9 nTPM
Lymph node	44.2 nTPM
Esophagus	39.3 nTPM
Lung	36.5 nTPM
Endometrium	36.5 nTPM
Liver	33.8 nTPM

Basal keratinocytes	58.5 nTPM
Skin	58.5 nTPM

Basal prostatic cells	57.4 nTPM
Prostate	57.4 nTPM

Basal respiratory cells	169.9 nTPM
Bronchus	169.9 nTPM

Basal squamous epithelial cells	53.5 nTPM
Esophagus	53.5 nTPM

Undifferentiated cells	51.1 nTPM
Colon	93.4 nTPM
Small intestine	35.5 nTPM
Rectum	24.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC