Single cell type - NCAPH2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NCAPH2
Gene descriptionⁱ Full gene name according to HGNC.	Non-SMC condensin II complex subunit H2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Cell cycle regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NCAPH2 is part of cluster 12 Non-specific - Cell cycle regulation with confidenceⁱ 1
294 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZWINT	ZW10 interacting kinetochore protein	0.6696	12
CDCA5	Cell division cycle associated 5	0.6434	12
POC1A	POC1 centriolar protein A	0.5924	12
CCDC167	Coiled-coil domain containing 167	0.5901	12
NABP2	Nucleic acid binding protein 2	0.5805	25
NUDT1	Nudix hydrolase 1	0.5774	12
ASF1B	Anti-silencing function 1B histone chaperone	0.5328	12
TK1	Thymidine kinase 1	0.5291	12
RNASEH2A	Ribonuclease H2 subunit A	0.5248	12
MAD2L2	Mitotic arrest deficient 2 like 2	0.5219	25
LSM4	LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated	0.5191	12
RRM2	Ribonucleotide reductase regulatory subunit M2	0.5184	12
PRC1	Protein regulator of cytokinesis 1	0.5162	12
CENPN	Centromere protein N	0.5105	12
MIS12	MIS12 kinetochore complex component	0.5102	25

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	10.1 nTPM
Breast	10.2 nTPM
Adipose tissue	10.0 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	24.5 nTPM
Lung	24.5 nTPM

Astrocytes	12.1 nTPM
Brain	12.1 nTPM

B-cells	15.9 nTPM
Liver	32.2 nTPM
PBMC	21.4 nTPM
Stomach	16.4 nTPM
Colon	16.0 nTPM
Adipose tissue	15.0 nTPM
Breast	14.7 nTPM
Kidney	14.3 nTPM
Lymph node	11.6 nTPM
Bone marrow	10.6 nTPM
Spleen	6.9 nTPM

Dendritic cells	15.5 nTPM
Adipose tissue	18.5 nTPM
PBMC	16.0 nTPM
Breast	12.0 nTPM

Endothelial cells	12.9 nTPM
Pancreas	30.9 nTPM
Heart muscle	18.6 nTPM
Lung	15.6 nTPM
Ovary	14.7 nTPM
Placenta	14.2 nTPM
Skin	14.1 nTPM
Skeletal muscle	12.3 nTPM
Testis	12.2 nTPM
Breast	10.0 nTPM
Prostate	9.9 nTPM
Liver	9.2 nTPM
Eye	8.1 nTPM
Endometrium	7.3 nTPM
Esophagus	3.1 nTPM

Fibroblasts	13.8 nTPM
Ovary	24.3 nTPM
Placenta	23.1 nTPM
Skin	18.1 nTPM
Skeletal muscle	14.3 nTPM
Lung	13.4 nTPM
Adipose tissue	12.6 nTPM
Breast	11.7 nTPM
Prostate	9.3 nTPM
Esophagus	9.2 nTPM
Heart muscle	8.2 nTPM
Stomach	7.4 nTPM

Intestinal goblet cells	18.8 nTPM
Small intestine	21.8 nTPM
Colon	20.8 nTPM
Rectum	13.8 nTPM

Macrophages	9.2 nTPM
Pancreas	23.0 nTPM
Adipose tissue	12.4 nTPM
Prostate	11.5 nTPM
Skeletal muscle	11.2 nTPM
Lung	10.6 nTPM
Breast	10.6 nTPM
Testis	8.8 nTPM
Stomach	8.8 nTPM
Bone marrow	8.7 nTPM
Ovary	8.0 nTPM
Endometrium	7.9 nTPM
Esophagus	6.3 nTPM
Spleen	5.2 nTPM
Kidney	4.6 nTPM
PBMC	0.0 nTPM

Paneth cells	13.5 nTPM
Rectum	15.9 nTPM
Colon	13.2 nTPM
Small intestine	11.3 nTPM

Plasma cells	26.6 nTPM
Spleen	35.5 nTPM
Bone marrow	33.0 nTPM
Adipose tissue	30.3 nTPM
Stomach	21.9 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	5.9 nTPM
Bronchus	7.4 nTPM
Lung	4.4 nTPM

Smooth muscle cells	16.9 nTPM
Pancreas	31.0 nTPM
Skin	24.1 nTPM
Bronchus	20.7 nTPM
Skeletal muscle	20.2 nTPM
Prostate	18.1 nTPM
Ovary	16.7 nTPM
Breast	15.8 nTPM
Adipose tissue	14.7 nTPM
Endometrium	10.2 nTPM
Esophagus	9.3 nTPM
Heart muscle	5.5 nTPM

T-cells	15.9 nTPM
Skin	29.9 nTPM
Colon	27.6 nTPM
Adipose tissue	20.5 nTPM
Skeletal muscle	18.7 nTPM
PBMC	17.8 nTPM
Endometrium	17.2 nTPM
Lung	16.7 nTPM
Breast	15.8 nTPM
Lymph node	15.7 nTPM
Kidney	15.1 nTPM
Stomach	13.9 nTPM
Liver	13.7 nTPM
Esophagus	13.1 nTPM
Bone marrow	12.8 nTPM
Spleen	11.1 nTPM
Prostate	9.5 nTPM
Ovary	2.2 nTPM

Basal keratinocytes	18.9 nTPM
Skin	18.9 nTPM

Basal prostatic cells	23.8 nTPM
Prostate	23.8 nTPM

Basal respiratory cells	17.5 nTPM
Bronchus	17.5 nTPM

Basal squamous epithelial cells	6.2 nTPM
Esophagus	6.2 nTPM

Undifferentiated cells	22.6 nTPM
Colon	29.2 nTPM
Small intestine	22.1 nTPM
Rectum	16.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC