Single cell type - ATP6V0A1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATP6V0A1
Gene descriptionⁱ Full gene name according to HGNC.	ATPase H+ transporting V0 subunit a1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Photoreceptor cells - Phototransduction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Rod photoreceptor cells, Cone photoreceptor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Rod photoreceptor cells, Cone photoreceptor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ATP6V0A1 is part of cluster 46 Photoreceptor cells - Phototransduction with confidenceⁱ 1
209 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZFYVE26	Zinc finger FYVE-type containing 26	0.6960	46
SRRM3	Serine/arginine repetitive matrix 3	0.6893	9
YPEL2	Yippee like 2	0.6789	46
PPEF2	Protein phosphatase with EF-hand domain 2	0.6661	46
UBAP1L	Ubiquitin associated protein 1 like	0.6645	9
SPTBN5	Spectrin beta, non-erythrocytic 5	0.6606	9
IGFL4	IGF like family member 4	0.6603	46
GLB1L2	Galactosidase beta 1 like 2	0.6599	46
KLHL34	Kelch like family member 34	0.6586	46
AHI1	Abelson helper integration site 1	0.6535	9
GRK1	G protein-coupled receptor kinase 1	0.6521	46
SLC2A11	Solute carrier family 2 member 11	0.6517	9
KIF1B	Kinesin family member 1B	0.6515	9
ABCG4	ATP binding cassette subfamily G member 4	0.6501	9
RGS9	Regulator of G protein signaling 9	0.6457	46

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	20.0 nTPM
Adipose tissue	21.3 nTPM
Breast	18.7 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	48.0 nTPM
Lung	48.0 nTPM

Astrocytes	47.0 nTPM
Brain	47.0 nTPM

B-cells	23.0 nTPM
Colon	36.7 nTPM
PBMC	34.3 nTPM
Lymph node	30.9 nTPM
Liver	29.8 nTPM
Breast	21.3 nTPM
Kidney	19.0 nTPM
Stomach	18.6 nTPM
Adipose tissue	17.1 nTPM
Bone marrow	12.3 nTPM
Spleen	10.0 nTPM

Dendritic cells	16.7 nTPM
PBMC	47.8 nTPM
Breast	1.5 nTPM
Adipose tissue	0.8 nTPM

Endothelial cells	22.2 nTPM
Eye	63.1 nTPM
Skin	32.9 nTPM
Heart muscle	29.6 nTPM
Ovary	23.9 nTPM
Endometrium	23.8 nTPM
Prostate	22.3 nTPM
Placenta	21.0 nTPM
Skeletal muscle	19.8 nTPM
Liver	15.6 nTPM
Breast	14.2 nTPM
Lung	12.5 nTPM
Esophagus	12.3 nTPM
Testis	11.9 nTPM
Pancreas	7.7 nTPM

Fibroblasts	31.0 nTPM
Prostate	66.0 nTPM
Lung	53.6 nTPM
Heart muscle	41.1 nTPM
Skin	36.7 nTPM
Adipose tissue	23.3 nTPM
Ovary	22.4 nTPM
Skeletal muscle	21.4 nTPM
Esophagus	21.4 nTPM
Breast	20.1 nTPM
Stomach	17.8 nTPM
Placenta	17.4 nTPM

Intestinal goblet cells	27.3 nTPM
Small intestine	31.5 nTPM
Colon	28.6 nTPM
Rectum	21.8 nTPM

Macrophages	42.8 nTPM
Ovary	114.1 nTPM
Prostate	78.0 nTPM
Pancreas	63.8 nTPM
Adipose tissue	44.4 nTPM
PBMC	40.9 nTPM
Skeletal muscle	38.8 nTPM
Lung	36.2 nTPM
Endometrium	36.2 nTPM
Breast	35.4 nTPM
Esophagus	29.9 nTPM
Bone marrow	27.5 nTPM
Spleen	27.0 nTPM
Testis	25.0 nTPM
Kidney	24.2 nTPM
Stomach	20.5 nTPM

Paneth cells	37.6 nTPM
Colon	46.1 nTPM
Small intestine	41.3 nTPM
Rectum	25.4 nTPM

Plasma cells	13.8 nTPM
Stomach	16.6 nTPM
Spleen	14.9 nTPM
Bone marrow	14.8 nTPM
Esophagus	12.3 nTPM
Adipose tissue	10.3 nTPM

Respiratory ciliated cells	11.4 nTPM
Bronchus	15.5 nTPM
Lung	7.3 nTPM

Smooth muscle cells	32.3 nTPM
Heart muscle	56.2 nTPM
Prostate	55.1 nTPM
Skin	48.5 nTPM
Skeletal muscle	40.1 nTPM
Adipose tissue	30.7 nTPM
Esophagus	29.4 nTPM
Breast	26.8 nTPM
Endometrium	20.9 nTPM
Ovary	20.0 nTPM
Bronchus	18.0 nTPM
Pancreas	10.0 nTPM

T-cells	6.9 nTPM
Prostate	28.4 nTPM
Skin	14.7 nTPM
Lung	13.6 nTPM
Esophagus	13.1 nTPM
Lymph node	8.6 nTPM
Endometrium	8.0 nTPM
PBMC	5.8 nTPM
Colon	4.7 nTPM
Kidney	4.7 nTPM
Breast	4.0 nTPM
Skeletal muscle	3.8 nTPM
Liver	2.4 nTPM
Adipose tissue	1.9 nTPM
Bone marrow	1.9 nTPM
Spleen	1.7 nTPM
Stomach	0.5 nTPM
Ovary	0.0 nTPM

Basal prostatic cells	56.7 nTPM
Prostate	56.7 nTPM

Basal respiratory cells	15.7 nTPM
Bronchus	15.7 nTPM

Basal squamous epithelial cells	32.5 nTPM
Esophagus	32.5 nTPM

Distal enterocytes	46.2 nTPM
Rectum	52.7 nTPM
Colon	39.7 nTPM

Undifferentiated cells	24.5 nTPM
Colon	29.0 nTPM
Rectum	23.2 nTPM
Small intestine	21.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC