Single cell type - APBA2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	APBA2
Gene descriptionⁱ Full gene name according to HGNC.	Amyloid beta precursor protein binding family A member 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells, Horizontal cells, Oligodendrocytes, NK-cells, Astrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (naive CD8 T-cell, naive CD4 T-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HEL, SH-SY5Y, U-937)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells, Horizontal cells, Oligodendrocytes, NK-cells, Astrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

APBA2 is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GPATCH8	G-patch domain containing 8	0.7229	21
ZNF786	Zinc finger protein 786	0.7068	63
PTPN4	Protein tyrosine phosphatase non-receptor type 4	0.6767	63
TXK	TXK tyrosine kinase	0.6334	63
NIM1K	NIM1 serine/threonine protein kinase	0.6044	21
RASGEF1A	RasGEF domain family member 1A	0.5878	63
KLRB1	Killer cell lectin like receptor B1	0.5710	63
ADGRB1	Adhesion G protein-coupled receptor B1	0.5708	62
ANXA2R	Annexin A2 receptor	0.5670	63
TRBC1	T cell receptor beta constant 1	0.5630	63
GRIA3	Glutamate ionotropic receptor AMPA type subunit 3	0.5580	21
DGKZ	Diacylglycerol kinase zeta	0.5551	63
TCERG1L	Transcription elongation regulator 1 like	0.5531	21
TRGC2	T cell receptor gamma constant 2	0.5506	63
TRAF3IP3	TRAF3 interacting protein 3	0.5495	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	0.5 nTPM
Breast	0.6 nTPM
Adipose tissue	0.5 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.6 nTPM
Lung	0.6 nTPM

B-cells	1.8 nTPM
PBMC	8.5 nTPM
Breast	2.6 nTPM
Liver	2.0 nTPM
Adipose tissue	2.0 nTPM
Bone marrow	1.7 nTPM
Lymph node	0.9 nTPM
Spleen	0.7 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Stomach	0.0 nTPM

Basal keratinocytes	0.4 nTPM
Skin	0.4 nTPM

Dendritic cells	36.5 nTPM
Adipose tissue	72.6 nTPM
Breast	36.8 nTPM
PBMC	0.0 nTPM

Endothelial cells	1.2 nTPM
Eye	6.5 nTPM
Skin	2.7 nTPM
Breast	2.2 nTPM
Placenta	1.1 nTPM
Endometrium	1.1 nTPM
Liver	0.9 nTPM
Heart muscle	0.7 nTPM
Skeletal muscle	0.6 nTPM
Prostate	0.5 nTPM
Ovary	0.5 nTPM
Testis	0.3 nTPM
Lung	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM

Fibroblasts	2.2 nTPM
Ovary	13.5 nTPM
Prostate	3.4 nTPM
Placenta	2.0 nTPM
Esophagus	1.7 nTPM
Breast	1.3 nTPM
Lung	1.2 nTPM
Skin	0.4 nTPM
Heart muscle	0.3 nTPM
Skeletal muscle	0.3 nTPM
Adipose tissue	0.3 nTPM
Stomach	0.0 nTPM

Intestinal goblet cells	0.3 nTPM
Colon	0.7 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	0.8 nTPM
Breast	4.3 nTPM
Bone marrow	2.5 nTPM
Adipose tissue	2.1 nTPM
Kidney	1.5 nTPM
Skeletal muscle	1.1 nTPM
Lung	0.3 nTPM
Ovary	0.1 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Endometrium	0.0 nTPM
Esophagus	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	12.3 nTPM
Adipose tissue	51.0 nTPM
Esophagus	6.1 nTPM
Spleen	2.9 nTPM
Bone marrow	1.7 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	0.2 nTPM
Bronchus	0.4 nTPM
Lung	0.0 nTPM

Smooth muscle cells	2.1 nTPM
Ovary	3.8 nTPM
Heart muscle	3.7 nTPM
Pancreas	3.5 nTPM
Esophagus	3.1 nTPM
Endometrium	2.8 nTPM
Skin	2.1 nTPM
Breast	1.3 nTPM
Adipose tissue	1.1 nTPM
Prostate	0.9 nTPM
Skeletal muscle	0.3 nTPM
Bronchus	0.0 nTPM

T-cells	30.7 nTPM
Ovary	86.7 nTPM
PBMC	76.3 nTPM
Liver	73.1 nTPM
Lymph node	35.5 nTPM
Adipose tissue	29.5 nTPM
Breast	27.8 nTPM
Skeletal muscle	26.8 nTPM
Spleen	26.5 nTPM
Endometrium	24.4 nTPM
Prostate	23.6 nTPM
Kidney	23.3 nTPM
Bone marrow	21.5 nTPM
Colon	15.2 nTPM
Stomach	14.8 nTPM
Lung	9.1 nTPM
Esophagus	6.6 nTPM
Skin	0.9 nTPM

Astrocytes	53.2 nTPM
Brain	53.2 nTPM

Distal tubular cells	1.9 nTPM
Kidney	1.9 nTPM

Early spermatids	18.9 nTPM
Testis	18.9 nTPM

Endometrial stromal cells	6.4 nTPM
Endometrium	6.4 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC