Single cell type - TIMP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TIMP2
Gene descriptionⁱ Full gene name according to HGNC.	TIMP metallopeptidase inhibitor 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Candidate cardiovascular disease genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Peritubular cells, Late spermatids, Fibroblasts, Leydig cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, fHDF/TERT166)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Peritubular cells, Late spermatids, Fibroblasts, Leydig cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TIMP2 is part of cluster 50 Fibroblasts - ECM organization with confidenceⁱ 1
441 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MMP27	Matrix metallopeptidase 27	0.6491	50
CTSK	Cathepsin K	0.6443	50
PI16	Peptidase inhibitor 16	0.6303	50
CCDC80	Coiled-coil domain containing 80	0.6260	50
OLFML1	Olfactomedin like 1	0.6234	50
H3Y1	H3.Y histone 1	0.6146	50
CFD	Complement factor D	0.6144	50
PTGFR	Prostaglandin F receptor	0.6128	50
LRRN4CL	LRRN4 C-terminal like	0.6122	50
OMD	Osteomodulin	0.6039	50
FSTL1	Follistatin like 1	0.6024	50
ELN	Elastin	0.5977	50
ANGPTL5	Angiopoietin like 5	0.5960	50
PLAC9	Placenta associated 9	0.5945	50
CLEC3B	C-type lectin domain family 3 member B	0.5942	50

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	147.9 nTPM
Adipose tissue	175.7 nTPM
Breast	120.1 nTPM

Alveolar cells type 1	112.2 nTPM
Lung	112.2 nTPM

Alveolar cells type 2	34.3 nTPM
Lung	34.3 nTPM

Astrocytes	24.2 nTPM
Brain	24.2 nTPM

B-cells	18.7 nTPM
Breast	111.1 nTPM
Liver	23.7 nTPM
Adipose tissue	21.0 nTPM
Colon	9.6 nTPM
Lymph node	7.3 nTPM
Bone marrow	4.9 nTPM
Spleen	4.5 nTPM
Stomach	3.2 nTPM
PBMC	1.4 nTPM
Kidney	0.0 nTPM

Dendritic cells	6.1 nTPM
Adipose tissue	7.9 nTPM
Breast	6.5 nTPM
PBMC	4.0 nTPM

Endothelial cells	115.0 nTPM
Liver	210.9 nTPM
Ovary	200.8 nTPM
Skin	189.0 nTPM
Eye	133.5 nTPM
Lung	127.9 nTPM
Endometrium	122.2 nTPM
Breast	111.9 nTPM
Testis	107.0 nTPM
Esophagus	105.5 nTPM
Skeletal muscle	90.6 nTPM
Heart muscle	81.9 nTPM
Prostate	60.7 nTPM
Placenta	56.8 nTPM
Pancreas	11.6 nTPM

Fibroblasts	475.9 nTPM
Adipose tissue	1216.3 nTPM
Skin	1020.3 nTPM
Esophagus	718.4 nTPM
Breast	525.2 nTPM
Skeletal muscle	507.5 nTPM
Heart muscle	361.9 nTPM
Ovary	273.2 nTPM
Prostate	241.4 nTPM
Stomach	240.6 nTPM
Lung	80.5 nTPM
Placenta	49.7 nTPM

Intestinal goblet cells	14.3 nTPM
Small intestine	21.7 nTPM
Rectum	11.9 nTPM
Colon	9.3 nTPM

Macrophages	184.8 nTPM
Ovary	841.7 nTPM
Adipose tissue	212.6 nTPM
Esophagus	201.5 nTPM
Spleen	191.9 nTPM
Breast	180.1 nTPM
Stomach	158.2 nTPM
Skeletal muscle	143.0 nTPM
Prostate	138.7 nTPM
Lung	138.1 nTPM
Endometrium	131.2 nTPM
Bone marrow	122.5 nTPM
Kidney	105.2 nTPM
Testis	104.5 nTPM
Pancreas	89.3 nTPM
PBMC	13.6 nTPM

Paneth cells	6.0 nTPM
Colon	16.5 nTPM
Rectum	1.6 nTPM
Small intestine	0.0 nTPM

Plasma cells	33.1 nTPM
Adipose tissue	89.0 nTPM
Esophagus	36.9 nTPM
Stomach	17.7 nTPM
Spleen	15.2 nTPM
Bone marrow	6.6 nTPM

Respiratory ciliated cells	5.4 nTPM
Bronchus	10.8 nTPM
Lung	0.0 nTPM

Smooth muscle cells	171.9 nTPM
Adipose tissue	314.7 nTPM
Ovary	257.9 nTPM
Prostate	222.0 nTPM
Skin	210.9 nTPM
Skeletal muscle	159.2 nTPM
Breast	153.8 nTPM
Endometrium	151.4 nTPM
Pancreas	117.2 nTPM
Heart muscle	113.8 nTPM
Bronchus	96.6 nTPM
Esophagus	93.1 nTPM

T-cells	17.5 nTPM
Skin	91.7 nTPM
Skeletal muscle	31.4 nTPM
Prostate	28.4 nTPM
Adipose tissue	28.1 nTPM
Lung	22.8 nTPM
Endometrium	22.4 nTPM
Esophagus	19.7 nTPM
Breast	15.4 nTPM
Ovary	8.9 nTPM
Lymph node	8.7 nTPM
Liver	4.5 nTPM
PBMC	3.7 nTPM
Spleen	3.1 nTPM
Stomach	2.6 nTPM
Colon	2.4 nTPM
Kidney	2.0 nTPM
Bone marrow	1.3 nTPM

Basal keratinocytes	98.9 nTPM
Skin	98.9 nTPM

Basal prostatic cells	9.0 nTPM
Prostate	9.0 nTPM

Basal respiratory cells	5.7 nTPM
Bronchus	5.7 nTPM

Basal squamous epithelial cells	9.1 nTPM
Esophagus	9.1 nTPM

Undifferentiated cells	2.3 nTPM
Small intestine	2.7 nTPM
Rectum	2.6 nTPM
Colon	1.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC