Single cell type - MYOM2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MYOM2
Gene descriptionⁱ Full gene name according to HGNC.	Myomesin 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cardiomyocytes - Muscle contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Cardiomyocytes, NK-cells, dendritic cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Group enriched (HEK93, SCLC-21H, U-266/84)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Cardiomyocytes, NK-cells, dendritic cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MYOM2 is part of cluster 54 Cardiomyocytes - Muscle contraction with confidenceⁱ 1
250 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
USP28	Ubiquitin specific peptidase 28	0.7621	54
SYNPO2L	Synaptopodin 2 like	0.7320	54
FLNC	Filamin C	0.7243	54
KLHL31	Kelch like family member 31	0.7195	54
MYH7	Myosin heavy chain 7	0.7185	54
MYL3	Myosin light chain 3	0.7173	54
HSPB7	Heat shock protein family B (small) member 7	0.7148	54
MYL2	Myosin light chain 2	0.7141	54
COX7A1	Cytochrome c oxidase subunit 7A1	0.7133	54
MYOM1	Myomesin 1	0.7093	54
SMCO1	Single-pass membrane protein with coiled-coil domains 1	0.7075	54
TECRL	Trans-2,3-enoyl-CoA reductase like	0.7074	54
ACTC1	Actin alpha cardiac muscle 1	0.7053	54
LDB3	LIM domain binding 3	0.7048	54
HRC	Histidine rich calcium binding protein	0.7045	54

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	3.7 nTPM
Breast	5.2 nTPM
Adipose tissue	2.2 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	3.0 nTPM
Lung	3.0 nTPM

Astrocytes	11.8 nTPM
Brain	11.8 nTPM

B-cells	1.6 nTPM
Breast	8.1 nTPM
Liver	1.7 nTPM
Bone marrow	1.7 nTPM
PBMC	1.4 nTPM
Lymph node	1.0 nTPM
Spleen	0.7 nTPM
Adipose tissue	0.5 nTPM
Stomach	0.5 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM

Dendritic cells	234.9 nTPM
Adipose tissue	472.0 nTPM
Breast	228.8 nTPM
PBMC	4.0 nTPM

Endothelial cells	5.6 nTPM
Heart muscle	43.4 nTPM
Lung	6.2 nTPM
Liver	4.6 nTPM
Breast	4.2 nTPM
Skin	4.1 nTPM
Skeletal muscle	3.0 nTPM
Prostate	2.6 nTPM
Testis	2.4 nTPM
Endometrium	2.4 nTPM
Esophagus	2.1 nTPM
Placenta	1.7 nTPM
Eye	0.8 nTPM
Ovary	0.5 nTPM
Pancreas	0.0 nTPM

Fibroblasts	26.7 nTPM
Heart muscle	166.2 nTPM
Prostate	81.1 nTPM
Breast	27.2 nTPM
Lung	4.5 nTPM
Esophagus	3.8 nTPM
Skin	3.6 nTPM
Adipose tissue	2.0 nTPM
Ovary	1.5 nTPM
Stomach	1.5 nTPM
Skeletal muscle	1.4 nTPM
Placenta	0.7 nTPM

Intestinal goblet cells	2.1 nTPM
Rectum	3.4 nTPM
Colon	2.9 nTPM
Small intestine	0.0 nTPM

Macrophages	4.8 nTPM
Adipose tissue	15.2 nTPM
PBMC	13.6 nTPM
Breast	11.4 nTPM
Esophagus	6.3 nTPM
Kidney	6.1 nTPM
Skeletal muscle	4.5 nTPM
Endometrium	4.4 nTPM
Lung	3.5 nTPM
Pancreas	2.5 nTPM
Spleen	2.1 nTPM
Ovary	2.0 nTPM
Prostate	1.2 nTPM
Testis	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.8 nTPM
Rectum	2.4 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	11.1 nTPM
Adipose tissue	55.5 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	5.3 nTPM
Lung	7.3 nTPM
Bronchus	3.3 nTPM

Smooth muscle cells	13.9 nTPM
Prostate	40.0 nTPM
Heart muscle	39.3 nTPM
Endometrium	27.4 nTPM
Esophagus	17.0 nTPM
Skin	12.8 nTPM
Breast	4.7 nTPM
Pancreas	4.5 nTPM
Skeletal muscle	2.9 nTPM
Adipose tissue	2.1 nTPM
Bronchus	1.9 nTPM
Ovary	0.3 nTPM

T-cells	22.3 nTPM
Ovary	113.5 nTPM
Skeletal muscle	93.8 nTPM
Liver	64.8 nTPM
Lung	28.8 nTPM
Adipose tissue	25.9 nTPM
Kidney	10.2 nTPM
Prostate	9.5 nTPM
PBMC	7.9 nTPM
Esophagus	6.6 nTPM
Breast	6.1 nTPM
Lymph node	3.0 nTPM
Endometrium	2.3 nTPM
Spleen	1.6 nTPM
Colon	1.4 nTPM
Skin	1.4 nTPM
Bone marrow	1.4 nTPM
Stomach	0.4 nTPM

Basal prostatic cells	2.7 nTPM
Prostate	2.7 nTPM

Cholangiocytes	20.0 nTPM
Liver	20.0 nTPM

Distal tubular cells	13.7 nTPM
Kidney	13.7 nTPM

Endometrial stromal cells	1.8 nTPM
Endometrium	1.8 nTPM

Undifferentiated cells	1.2 nTPM
Rectum	1.9 nTPM
Colon	1.2 nTPM
Small intestine	0.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC