Single cell type - RPL26L1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RPL26L1
Gene descriptionⁱ Full gene name according to HGNC.	Ribosomal protein L26 like 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Ribosomal proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Spermatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Spermatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RPL26L1 is part of cluster 66 Spermatocytes - Spermatogenesis with confidenceⁱ 0.98
507 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MRPL47	Mitochondrial ribosomal protein L47	0.6499	66
NAA20	N-alpha-acetyltransferase 20, NatB catalytic subunit	0.6216	26
PFDN4	Prefoldin subunit 4	0.5900	66
PSMG2	Proteasome assembly chaperone 2	0.5791	66
SLIRP	SRA stem-loop interacting RNA binding protein	0.5675	39
GTF2H5	General transcription factor IIH subunit 5	0.5546	39
GEMIN6	Gem nuclear organelle associated protein 6	0.5364	23
DHX30	DExH-box helicase 30	0.5281	66
TPRKB	TP53RK binding protein	0.5250	66
CHCHD5	Coiled-coil-helix-coiled-coil-helix domain containing 5	0.5111	39
PNLDC1	PARN like, ribonuclease domain containing 1	0.4906	20
MRPL39	Mitochondrial ribosomal protein L39	0.4807	66
LLPH	LLP homolog, long-term synaptic facilitation factor	0.4787	66
CCDC34	Coiled-coil domain containing 34	0.4783	12
TRMT10A	TRNA methyltransferase 10A	0.4768	13

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	41.5 nTPM
Breast	51.2 nTPM
Adipose tissue	31.8 nTPM

Alveolar cells type 1	41.7 nTPM
Lung	41.7 nTPM

Alveolar cells type 2	32.8 nTPM
Lung	32.8 nTPM

Astrocytes	4.6 nTPM
Brain	4.6 nTPM

B-cells	29.8 nTPM
Liver	125.4 nTPM
Kidney	28.5 nTPM
PBMC	25.7 nTPM
Breast	24.1 nTPM
Lymph node	21.5 nTPM
Colon	20.8 nTPM
Spleen	17.3 nTPM
Stomach	16.4 nTPM
Bone marrow	12.3 nTPM
Adipose tissue	6.0 nTPM

Dendritic cells	28.7 nTPM
PBMC	47.8 nTPM
Breast	25.9 nTPM
Adipose tissue	12.4 nTPM

Endothelial cells	47.7 nTPM
Placenta	100.6 nTPM
Pancreas	69.5 nTPM
Ovary	61.6 nTPM
Prostate	53.3 nTPM
Testis	51.0 nTPM
Skin	49.0 nTPM
Endometrium	48.4 nTPM
Breast	45.6 nTPM
Liver	43.1 nTPM
Esophagus	39.3 nTPM
Skeletal muscle	34.2 nTPM
Eye	25.9 nTPM
Heart muscle	23.7 nTPM
Lung	21.8 nTPM

Fibroblasts	45.3 nTPM
Placenta	104.0 nTPM
Ovary	86.7 nTPM
Skin	41.7 nTPM
Breast	38.2 nTPM
Lung	38.0 nTPM
Adipose tissue	35.6 nTPM
Stomach	34.1 nTPM
Prostate	33.0 nTPM
Esophagus	31.4 nTPM
Heart muscle	29.3 nTPM
Skeletal muscle	26.6 nTPM

Intestinal goblet cells	48.6 nTPM
Colon	52.9 nTPM
Small intestine	47.4 nTPM
Rectum	45.6 nTPM

Macrophages	45.6 nTPM
Pancreas	97.0 nTPM
Kidney	70.4 nTPM
Ovary	66.3 nTPM
Testis	62.1 nTPM
Breast	51.9 nTPM
Endometrium	46.8 nTPM
Lung	42.3 nTPM
Skeletal muscle	38.5 nTPM
Prostate	37.9 nTPM
Esophagus	37.7 nTPM
Stomach	32.2 nTPM
Adipose tissue	31.3 nTPM
Bone marrow	28.7 nTPM
Spleen	27.9 nTPM
PBMC	13.6 nTPM

Paneth cells	38.6 nTPM
Rectum	51.3 nTPM
Small intestine	41.3 nTPM
Colon	23.1 nTPM

Plasma cells	59.2 nTPM
Spleen	85.4 nTPM
Esophagus	80.1 nTPM
Bone marrow	79.1 nTPM
Stomach	40.9 nTPM
Adipose tissue	10.3 nTPM

Respiratory ciliated cells	92.4 nTPM
Bronchus	116.2 nTPM
Lung	68.5 nTPM

Smooth muscle cells	56.1 nTPM
Pancreas	162.5 nTPM
Ovary	85.1 nTPM
Heart muscle	53.6 nTPM
Endometrium	51.9 nTPM
Bronchus	49.9 nTPM
Prostate	41.6 nTPM
Skin	38.0 nTPM
Skeletal muscle	38.0 nTPM
Esophagus	34.1 nTPM
Breast	31.4 nTPM
Adipose tissue	31.1 nTPM

T-cells	28.9 nTPM
Kidney	63.6 nTPM
Esophagus	52.4 nTPM
PBMC	39.1 nTPM
Liver	38.0 nTPM
Skin	36.8 nTPM
Endometrium	35.6 nTPM
Breast	27.2 nTPM
Bone marrow	25.3 nTPM
Stomach	24.4 nTPM
Lymph node	24.2 nTPM
Spleen	23.6 nTPM
Skeletal muscle	20.6 nTPM
Lung	19.7 nTPM
Colon	17.6 nTPM
Ovary	15.6 nTPM
Prostate	14.2 nTPM
Adipose tissue	13.8 nTPM

Basal keratinocytes	48.8 nTPM
Skin	48.8 nTPM

Basal prostatic cells	56.9 nTPM
Prostate	56.9 nTPM

Basal respiratory cells	191.3 nTPM
Bronchus	191.3 nTPM

Basal squamous epithelial cells	32.5 nTPM
Esophagus	32.5 nTPM

Undifferentiated cells	59.1 nTPM
Small intestine	62.9 nTPM
Colon	59.0 nTPM
Rectum	55.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC