Single cell type - CAPG - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CAPG
Gene descriptionⁱ Full gene name according to HGNC.	Capping actin protein, gelsolin like
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells, granulocytes, monocytes, Macrophages)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (myeloid DC, classical monocyte, basophil, plasmacytoid DC, eosinophil, NK-cell, memory B-cell, naive B-cell, intermediate monocyte)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CAPAN-2, HMC-1, SK-MEL-30, THP-1, U-937)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells, granulocytes, monocytes, Macrophages)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CAPG is part of cluster 4 Macrophages - Innate immune response with confidenceⁱ 1
228 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CXCL5	C-X-C motif chemokine ligand 5	0.8334	4
ADAMDEC1	ADAM like decysin 1	0.7655	4
TM4SF19	Transmembrane 4 L six family member 19	0.7561	4
DCSTAMP	Dendrocyte expressed seven transmembrane protein	0.7475	4
MMP9	Matrix metallopeptidase 9	0.7424	4
DCANP1	Dendritic cell associated nuclear protein	0.7402	4
TREM2	Triggering receptor expressed on myeloid cells 2	0.7327	4
CTSD	Cathepsin D	0.7263	4
PLA2G7	Phospholipase A2 group VII	0.7225	4
GPR84	G protein-coupled receptor 84	0.7196	4
ACP5	Acid phosphatase 5, tartrate resistant	0.7175	4
CCL7	C-C motif chemokine ligand 7	0.7170	4
CTSB	Cathepsin B	0.7120	4
CHIT1	Chitinase 1	0.7028	4
CD68	CD68 molecule	0.7007	4

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	6.6 nTPM
Breast	9.1 nTPM
Adipose tissue	4.1 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	24.5 nTPM
Lung	24.5 nTPM

Astrocytes	3.3 nTPM
Brain	3.3 nTPM

B-cells	84.7 nTPM
Stomach	141.7 nTPM
Kidney	128.5 nTPM
Colon	124.6 nTPM
Bone marrow	97.2 nTPM
Lymph node	80.0 nTPM
Adipose tissue	74.2 nTPM
Breast	68.3 nTPM
Spleen	58.5 nTPM
PBMC	55.7 nTPM
Liver	18.2 nTPM

Dendritic cells	91.5 nTPM
PBMC	203.2 nTPM
Adipose tissue	48.3 nTPM
Breast	22.9 nTPM

Endothelial cells	16.2 nTPM
Eye	86.6 nTPM
Skin	44.6 nTPM
Placenta	18.8 nTPM
Prostate	17.1 nTPM
Esophagus	14.0 nTPM
Breast	13.0 nTPM
Endometrium	6.7 nTPM
Lung	6.2 nTPM
Testis	6.2 nTPM
Ovary	5.4 nTPM
Skeletal muscle	3.5 nTPM
Liver	2.7 nTPM
Heart muscle	1.8 nTPM
Pancreas	0.0 nTPM

Fibroblasts	34.7 nTPM
Skin	106.9 nTPM
Breast	55.8 nTPM
Adipose tissue	50.6 nTPM
Placenta	49.6 nTPM
Skeletal muscle	34.1 nTPM
Prostate	22.8 nTPM
Lung	15.7 nTPM
Stomach	14.9 nTPM
Esophagus	13.2 nTPM
Ovary	9.9 nTPM
Heart muscle	8.2 nTPM

Intestinal goblet cells	55.9 nTPM
Colon	70.7 nTPM
Rectum	62.7 nTPM
Small intestine	34.2 nTPM

Macrophages	432.1 nTPM
Pancreas	2049.6 nTPM
Ovary	1138.1 nTPM
Prostate	506.7 nTPM
Breast	449.7 nTPM
Testis	438.6 nTPM
Kidney	339.6 nTPM
Endometrium	289.7 nTPM
Stomach	272.5 nTPM
Lung	251.5 nTPM
Esophagus	237.6 nTPM
Spleen	132.7 nTPM
Skeletal muscle	125.6 nTPM
Adipose tissue	120.2 nTPM
Bone marrow	88.7 nTPM
PBMC	40.9 nTPM

Paneth cells	205.4 nTPM
Colon	375.5 nTPM
Rectum	131.9 nTPM
Small intestine	108.8 nTPM

Plasma cells	17.2 nTPM
Esophagus	30.7 nTPM
Stomach	22.7 nTPM
Adipose tissue	22.5 nTPM
Spleen	5.1 nTPM
Bone marrow	5.0 nTPM

Respiratory ciliated cells	48.8 nTPM
Bronchus	87.4 nTPM
Lung	10.2 nTPM

Smooth muscle cells	54.0 nTPM
Bronchus	472.8 nTPM
Skin	29.7 nTPM
Pancreas	27.2 nTPM
Breast	25.7 nTPM
Adipose tissue	11.6 nTPM
Prostate	10.1 nTPM
Esophagus	6.2 nTPM
Endometrium	4.2 nTPM
Skeletal muscle	2.7 nTPM
Ovary	2.2 nTPM
Heart muscle	1.7 nTPM

T-cells	101.9 nTPM
Stomach	291.1 nTPM
Skin	271.7 nTPM
Prostate	203.6 nTPM
Esophagus	183.4 nTPM
Colon	164.9 nTPM
Endometrium	122.6 nTPM
Breast	101.4 nTPM
Lung	92.7 nTPM
Ovary	71.2 nTPM
Kidney	64.3 nTPM
Skeletal muscle	52.2 nTPM
Adipose tissue	32.4 nTPM
Liver	20.7 nTPM
PBMC	15.6 nTPM
Spleen	15.6 nTPM
Bone marrow	15.1 nTPM
Lymph node	13.9 nTPM

Basal keratinocytes	121.2 nTPM
Skin	121.2 nTPM

Basal prostatic cells	167.5 nTPM
Prostate	167.5 nTPM

Basal respiratory cells	265.0 nTPM
Bronchus	265.0 nTPM

Basal squamous epithelial cells	60.9 nTPM
Esophagus	60.9 nTPM

Undifferentiated cells	83.9 nTPM
Colon	123.6 nTPM
Rectum	91.4 nTPM
Small intestine	36.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC