Single cell type - AP2S1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AP2S1
Gene descriptionⁱ Full gene name according to HGNC.	Adaptor related protein complex 2 subunit sigma 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

AP2S1 is part of cluster 4 Macrophages - Innate immune response with confidenceⁱ 1
228 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TFPT	TCF3 fusion partner	0.6064	4
TWF2	Twinfilin actin binding protein 2	0.5953	3
ATP6V0D1	ATPase H+ transporting V0 subunit d1	0.5950	4
LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1	0.5757	51
AP2M1	Adaptor related protein complex 2 subunit mu 1	0.5718	10
RHOG	Ras homolog family member G	0.5712	3
PLA2G7	Phospholipase A2 group VII	0.5601	4
MMP9	Matrix metallopeptidase 9	0.5502	4
ARPC4	Actin related protein 2/3 complex subunit 4	0.5498	3
CTSD	Cathepsin D	0.5475	4
SDSL	Serine dehydratase like	0.5447	3
CD14	CD14 molecule	0.5447	4
RILP	Rab interacting lysosomal protein	0.5414	53
BCKDK	Branched chain keto acid dehydrogenase kinase	0.5397	4
POLR2E	RNA polymerase II, I and III subunit E	0.5385	3

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	129.0 nTPM
Breast	175.6 nTPM
Adipose tissue	82.4 nTPM

Alveolar cells type 1	38.5 nTPM
Lung	38.5 nTPM

Alveolar cells type 2	57.2 nTPM
Lung	57.2 nTPM

Astrocytes	10.4 nTPM
Brain	10.4 nTPM

B-cells	85.9 nTPM
Liver	174.9 nTPM
PBMC	122.8 nTPM
Colon	113.4 nTPM
Kidney	100.0 nTPM
Breast	77.5 nTPM
Bone marrow	72.7 nTPM
Spleen	72.7 nTPM
Stomach	55.8 nTPM
Adipose tissue	40.1 nTPM
Lymph node	28.6 nTPM

Dendritic cells	100.9 nTPM
PBMC	127.5 nTPM
Breast	101.6 nTPM
Adipose tissue	73.5 nTPM

Endothelial cells	190.6 nTPM
Ovary	386.5 nTPM
Placenta	385.4 nTPM
Pancreas	359.0 nTPM
Liver	285.3 nTPM
Prostate	256.2 nTPM
Skin	205.8 nTPM
Testis	151.1 nTPM
Endometrium	151.0 nTPM
Breast	142.4 nTPM
Esophagus	90.1 nTPM
Lung	74.8 nTPM
Eye	73.7 nTPM
Skeletal muscle	69.2 nTPM
Heart muscle	37.9 nTPM

Enteroendocrine cells	163.7 nTPM
Colon	206.0 nTPM
Rectum	121.4 nTPM

Erythroid cells	250.7 nTPM
Liver	374.4 nTPM
Bone marrow	127.0 nTPM

Fibroblasts	130.2 nTPM
Placenta	312.4 nTPM
Ovary	272.5 nTPM
Breast	148.0 nTPM
Skin	145.1 nTPM
Adipose tissue	124.7 nTPM
Prostate	94.0 nTPM
Esophagus	81.8 nTPM
Skeletal muscle	74.8 nTPM
Stomach	69.8 nTPM
Lung	60.3 nTPM
Heart muscle	49.1 nTPM

Intestinal goblet cells	259.6 nTPM
Colon	414.5 nTPM
Small intestine	197.9 nTPM
Rectum	166.5 nTPM

Macrophages	389.5 nTPM
Pancreas	806.6 nTPM
Kidney	745.7 nTPM
Ovary	720.7 nTPM
Bone marrow	368.6 nTPM
Prostate	362.3 nTPM
Testis	342.8 nTPM
PBMC	341.0 nTPM
Spleen	324.6 nTPM
Stomach	313.6 nTPM
Esophagus	278.5 nTPM
Breast	271.9 nTPM
Endometrium	271.0 nTPM
Adipose tissue	253.3 nTPM
Skeletal muscle	226.4 nTPM
Lung	216.2 nTPM

Paneth cells	333.9 nTPM
Colon	556.7 nTPM
Small intestine	251.5 nTPM
Rectum	193.5 nTPM

Plasma cells	94.8 nTPM
Spleen	165.7 nTPM
Bone marrow	153.3 nTPM
Stomach	62.3 nTPM
Esophagus	49.4 nTPM
Adipose tissue	43.2 nTPM

Respiratory ciliated cells	89.0 nTPM
Bronchus	138.6 nTPM
Lung	39.4 nTPM

Basal keratinocytes	171.6 nTPM
Skin	171.6 nTPM

Basal prostatic cells	103.9 nTPM
Prostate	103.9 nTPM

Basal respiratory cells	341.6 nTPM
Bronchus	341.6 nTPM

Basal squamous epithelial cells	73.4 nTPM
Esophagus	73.4 nTPM

Smooth muscle cells	173.9 nTPM
Pancreas	723.0 nTPM
Ovary	272.5 nTPM
Bronchus	226.6 nTPM
Breast	114.8 nTPM
Skin	112.3 nTPM
Prostate	107.5 nTPM
Endometrium	105.9 nTPM
Adipose tissue	73.2 nTPM
Esophagus	65.2 nTPM
Skeletal muscle	56.5 nTPM
Heart muscle	55.3 nTPM

T-cells	87.9 nTPM
Kidney	168.3 nTPM
Liver	134.9 nTPM
Ovary	126.8 nTPM
PBMC	124.6 nTPM
Colon	112.6 nTPM
Skin	110.0 nTPM
Bone marrow	79.8 nTPM
Esophagus	78.6 nTPM
Breast	77.9 nTPM
Spleen	76.9 nTPM
Stomach	72.5 nTPM
Skeletal muscle	68.2 nTPM
Endometrium	64.7 nTPM
Lung	54.6 nTPM
Prostate	52.1 nTPM
Adipose tissue	47.9 nTPM
Lymph node	43.1 nTPM

Undifferentiated cells	282.1 nTPM
Colon	405.2 nTPM
Small intestine	244.7 nTPM
Rectum	196.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC