Single cell type - RRM2B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RRM2B
Gene descriptionⁱ Full gene name according to HGNC.	Ribonucleotide reductase regulatory TP53 inducible subunit M2B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Plasmacytoid DCs - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RRM2B is part of cluster 65 Plasmacytoid DCs - Unknown function with confidenceⁱ 1
144 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MAP3K2	Mitogen-activated protein kinase kinase kinase 2	0.5651	65
IRF8	Interferon regulatory factor 8	0.5481	65
CNTF	Ciliary neurotrophic factor	0.5422	49
NR4A3	Nuclear receptor subfamily 4 group A member 3	0.5404	41
CIITA	Class II major histocompatibility complex transactivator	0.5379	41
GPR183	G protein-coupled receptor 183	0.5240	65
SH2B3	SH2B adaptor protein 3	0.5116	65
CPNE3	Copine 3	0.5083	41
ETV3	ETS variant transcription factor 3	0.5052	41
HLA-DOA	Major histocompatibility complex, class II, DO alpha	0.5018	41
TNFSF9	TNF superfamily member 9	0.4986	65
WDFY4	WDFY family member 4	0.4979	41
CBFA2T3	CBFA2/RUNX1 partner transcriptional co-repressor 3	0.4951	65
TAMALIN	Trafficking regulator and scaffold protein tamalin	0.4947	65
HPS3	HPS3 biogenesis of lysosomal organelles complex 2 subunit 1	0.4876	57

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	16.2 nTPM
Adipose tissue	19.4 nTPM
Breast	12.9 nTPM

Alveolar cells type 1	57.7 nTPM
Lung	57.7 nTPM

Alveolar cells type 2	29.3 nTPM
Lung	29.3 nTPM

Astrocytes	10.1 nTPM
Brain	10.1 nTPM

B-cells	33.5 nTPM
Stomach	57.2 nTPM
Colon	55.9 nTPM
Adipose tissue	54.2 nTPM
Lymph node	46.6 nTPM
Spleen	43.6 nTPM
Bone marrow	31.9 nTPM
PBMC	17.1 nTPM
Kidney	14.3 nTPM
Breast	10.7 nTPM
Liver	3.9 nTPM

Dendritic cells	13.9 nTPM
Adipose tissue	22.9 nTPM
Breast	11.0 nTPM
PBMC	8.0 nTPM

Endothelial cells	14.9 nTPM
Eye	22.7 nTPM
Lung	21.8 nTPM
Esophagus	20.6 nTPM
Heart muscle	20.5 nTPM
Liver	18.3 nTPM
Breast	15.4 nTPM
Endometrium	14.8 nTPM
Skeletal muscle	14.0 nTPM
Skin	13.6 nTPM
Prostate	13.2 nTPM
Ovary	11.5 nTPM
Testis	9.5 nTPM
Pancreas	7.7 nTPM
Placenta	5.7 nTPM

Fibroblasts	14.8 nTPM
Esophagus	28.5 nTPM
Heart muscle	20.1 nTPM
Lung	20.1 nTPM
Skin	17.8 nTPM
Skeletal muscle	17.2 nTPM
Adipose tissue	13.9 nTPM
Breast	11.6 nTPM
Prostate	9.3 nTPM
Stomach	8.9 nTPM
Ovary	8.3 nTPM
Placenta	6.8 nTPM

Intestinal goblet cells	9.7 nTPM
Small intestine	12.6 nTPM
Rectum	11.4 nTPM
Colon	5.0 nTPM

Macrophages	23.8 nTPM
Esophagus	45.6 nTPM
Adipose tissue	41.0 nTPM
Spleen	36.3 nTPM
Lung	29.7 nTPM
Skeletal muscle	28.3 nTPM
Ovary	26.9 nTPM
Stomach	26.4 nTPM
Bone marrow	26.2 nTPM
Testis	23.8 nTPM
Breast	22.5 nTPM
Endometrium	17.5 nTPM
Kidney	14.3 nTPM
Prostate	10.3 nTPM
Pancreas	7.7 nTPM
PBMC	0.0 nTPM

Paneth cells	5.7 nTPM
Rectum	9.7 nTPM
Small intestine	7.5 nTPM
Colon	0.0 nTPM

Plasma cells	9.3 nTPM
Adipose tissue	16.1 nTPM
Esophagus	12.3 nTPM
Stomach	9.8 nTPM
Spleen	4.8 nTPM
Bone marrow	3.3 nTPM

Respiratory ciliated cells	39.9 nTPM
Lung	42.3 nTPM
Bronchus	37.4 nTPM

Smooth muscle cells	16.8 nTPM
Heart muscle	44.9 nTPM
Esophagus	21.7 nTPM
Bronchus	21.5 nTPM
Adipose tissue	15.6 nTPM
Endometrium	14.7 nTPM
Skeletal muscle	14.4 nTPM
Pancreas	13.2 nTPM
Skin	10.5 nTPM
Breast	9.9 nTPM
Prostate	9.4 nTPM
Ovary	9.4 nTPM

T-cells	12.2 nTPM
Lymph node	19.6 nTPM
Spleen	19.4 nTPM
Adipose tissue	16.5 nTPM
Colon	16.1 nTPM
Skin	14.7 nTPM
Stomach	14.0 nTPM
Breast	13.9 nTPM
Lung	13.6 nTPM
Bone marrow	13.3 nTPM
Esophagus	13.1 nTPM
Skeletal muscle	12.7 nTPM
Endometrium	11.3 nTPM
Liver	8.5 nTPM
Kidney	8.2 nTPM
PBMC	6.0 nTPM
Prostate	4.7 nTPM
Ovary	2.2 nTPM

Basal respiratory cells	11.8 nTPM
Bronchus	11.8 nTPM

Basal squamous epithelial cells	34.1 nTPM
Esophagus	34.1 nTPM

Cholangiocytes	20.0 nTPM
Liver	20.0 nTPM

Collecting duct cells	40.5 nTPM
Kidney	40.5 nTPM

Undifferentiated cells	12.1 nTPM
Rectum	16.3 nTPM
Small intestine	12.0 nTPM
Colon	8.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC