Single cell type - BCAR1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BCAR1
Gene descriptionⁱ Full gene name according to HGNC.	BCAR1 scaffold protein, Cas family member
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	17

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

BCAR1 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
DAPK3	Death associated protein kinase 3	0.6230	1
FBLIM1	Filamin binding LIM protein 1	0.5976	53
CD151	CD151 molecule (Raph blood group)	0.5733	1
ACTN4	Actinin alpha 4	0.5679	53
CHMP4B	Charged multivesicular body protein 4B	0.5632	53
PDGFA	Platelet derived growth factor subunit A	0.5587	48
CDC42EP5	CDC42 effector protein 5	0.5446	53
CEACAM1	CEA cell adhesion molecule 1	0.5430	53
SLCO2A1	Solute carrier organic anion transporter family member 2A1	0.5405	14
ACHE	Acetylcholinesterase (Cartwright blood group)	0.5398	53
BATF2	Basic leucine zipper ATF-like transcription factor 2	0.5265	53
SQSTM1	Sequestosome 1	0.5252	22
CDC42EP1	CDC42 effector protein 1	0.5215	1
HES4	Hes family bHLH transcription factor 4	0.5205	48
CLIP2	CAP-Gly domain containing linker protein 2	0.5197	42

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	30.1 nTPM
Adipose tissue	37.1 nTPM
Breast	23.2 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	6.9 nTPM
Lung	6.9 nTPM

Astrocytes	9.4 nTPM
Brain	9.4 nTPM

B-cells	1.2 nTPM
Colon	4.8 nTPM
Kidney	4.8 nTPM
Breast	1.3 nTPM
Stomach	0.5 nTPM
Liver	0.4 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Dendritic cells	0.7 nTPM
Breast	2.2 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM

Endothelial cells	49.2 nTPM
Skin	80.4 nTPM
Prostate	75.7 nTPM
Placenta	71.6 nTPM
Ovary	70.8 nTPM
Pancreas	61.8 nTPM
Skeletal muscle	50.8 nTPM
Endometrium	48.9 nTPM
Liver	44.0 nTPM
Testis	41.5 nTPM
Lung	37.4 nTPM
Breast	34.9 nTPM
Esophagus	34.6 nTPM
Heart muscle	22.4 nTPM
Eye	13.7 nTPM

Fibroblasts	21.1 nTPM
Prostate	48.6 nTPM
Placenta	42.4 nTPM
Skin	26.9 nTPM
Ovary	22.5 nTPM
Lung	19.0 nTPM
Stomach	17.8 nTPM
Skeletal muscle	16.0 nTPM
Breast	11.6 nTPM
Esophagus	10.0 nTPM
Adipose tissue	9.0 nTPM
Heart muscle	7.9 nTPM

Intestinal goblet cells	42.1 nTPM
Colon	45.8 nTPM
Small intestine	43.6 nTPM
Rectum	37.0 nTPM

Macrophages	2.1 nTPM
Stomach	5.9 nTPM
Lung	4.7 nTPM
Prostate	4.6 nTPM
Endometrium	3.4 nTPM
Testis	2.9 nTPM
Pancreas	2.5 nTPM
Kidney	2.3 nTPM
Skeletal muscle	1.7 nTPM
Esophagus	1.6 nTPM
Breast	1.1 nTPM
Ovary	0.7 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Paneth cells	59.6 nTPM
Colon	88.9 nTPM
Small intestine	56.3 nTPM
Rectum	33.6 nTPM

Plasma cells	1.4 nTPM
Esophagus	6.1 nTPM
Adipose tissue	0.6 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	13.1 nTPM
Bronchus	21.9 nTPM
Lung	4.4 nTPM

Smooth muscle cells	38.5 nTPM
Pancreas	90.4 nTPM
Skin	82.3 nTPM
Ovary	56.0 nTPM
Prostate	53.4 nTPM
Endometrium	36.7 nTPM
Skeletal muscle	29.8 nTPM
Adipose tissue	22.8 nTPM
Breast	21.8 nTPM
Esophagus	15.5 nTPM
Heart muscle	8.8 nTPM
Bronchus	6.5 nTPM

T-cells	2.2 nTPM
Prostate	14.2 nTPM
Endometrium	5.3 nTPM
Skin	4.6 nTPM
Colon	3.8 nTPM
Kidney	3.4 nTPM
Ovary	2.2 nTPM
Skeletal muscle	1.8 nTPM
Liver	0.9 nTPM
Breast	0.7 nTPM
Stomach	0.5 nTPM
Lung	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Basal keratinocytes	28.0 nTPM
Skin	28.0 nTPM

Basal prostatic cells	59.7 nTPM
Prostate	59.7 nTPM

Basal respiratory cells	36.8 nTPM
Bronchus	36.8 nTPM

Cholangiocytes	31.5 nTPM
Liver	31.5 nTPM

Undifferentiated cells	33.7 nTPM
Colon	44.3 nTPM
Rectum	33.9 nTPM
Small intestine	22.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC