Single cell type - MRTO4 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MRTO4
Gene descriptionⁱ Full gene name according to HGNC.	MRT4 homolog, ribosome maturation factor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Ribosomal proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MRTO4 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 0.99
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GPATCH4	G-patch domain containing 4	0.7057	39
CCT6A	Chaperonin containing TCP1 subunit 6A	0.6764	39
BOP1	BOP1 ribosomal biogenesis factor	0.6607	39
BYSL	Bystin like	0.6543	39
DPH2	Diphthamide biosynthesis 2	0.6480	39
ATAD3A	ATPase family AAA domain containing 3A	0.6149	39
GRWD1	Glutamate rich WD repeat containing 1	0.6145	39
PIGW	Phosphatidylinositol glycan anchor biosynthesis class W	0.6069	39
PUS1	Pseudouridine synthase 1	0.6056	39
TOMM40	Translocase of outer mitochondrial membrane 40	0.5979	39
NME1	NME/NM23 nucleoside diphosphate kinase 1	0.5971	10
SRRD	SRR1 domain containing	0.5943	1
CDK4	Cyclin dependent kinase 4	0.5858	39
NIP7	Nucleolar pre-rRNA processing protein NIP7	0.5841	39
PPAN	Peter pan homolog	0.5759	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	30.0 nTPM
Breast	34.6 nTPM
Adipose tissue	25.4 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	14.5 nTPM
Lung	14.5 nTPM

Astrocytes	6.2 nTPM
Brain	6.2 nTPM

B-cells	31.2 nTPM
Liver	53.6 nTPM
Spleen	48.8 nTPM
Stomach	39.1 nTPM
Colon	36.7 nTPM
Bone marrow	31.9 nTPM
PBMC	28.5 nTPM
Lymph node	19.1 nTPM
Kidney	19.0 nTPM
Adipose tissue	17.6 nTPM
Breast	17.3 nTPM

Dendritic cells	14.9 nTPM
PBMC	16.0 nTPM
Breast	14.9 nTPM
Adipose tissue	13.9 nTPM

Endothelial cells	32.1 nTPM
Pancreas	92.6 nTPM
Placenta	48.9 nTPM
Prostate	43.7 nTPM
Ovary	41.4 nTPM
Endometrium	34.3 nTPM
Testis	28.2 nTPM
Skin	27.6 nTPM
Lung	24.9 nTPM
Esophagus	24.3 nTPM
Breast	21.7 nTPM
Skeletal muscle	20.4 nTPM
Liver	18.3 nTPM
Eye	16.2 nTPM
Heart muscle	7.7 nTPM

Fibroblasts	29.5 nTPM
Ovary	62.4 nTPM
Placenta	36.4 nTPM
Adipose tissue	34.9 nTPM
Prostate	32.7 nTPM
Lung	32.4 nTPM
Skeletal muscle	28.2 nTPM
Stomach	23.7 nTPM
Skin	22.6 nTPM
Breast	22.6 nTPM
Esophagus	14.0 nTPM
Heart muscle	13.9 nTPM

Intestinal goblet cells	25.4 nTPM
Colon	39.3 nTPM
Rectum	18.6 nTPM
Small intestine	18.2 nTPM

Macrophages	21.0 nTPM
Pancreas	74.0 nTPM
Kidney	33.3 nTPM
Testis	25.5 nTPM
Breast	24.9 nTPM
Lung	23.9 nTPM
Endometrium	20.5 nTPM
Skeletal muscle	16.4 nTPM
Ovary	16.1 nTPM
Adipose tissue	14.8 nTPM
Bone marrow	13.8 nTPM
PBMC	13.6 nTPM
Prostate	12.6 nTPM
Spleen	9.3 nTPM
Stomach	8.8 nTPM
Esophagus	7.9 nTPM

Paneth cells	17.0 nTPM
Rectum	26.0 nTPM
Small intestine	15.0 nTPM
Colon	9.9 nTPM

Plasma cells	29.0 nTPM
Bone marrow	62.6 nTPM
Spleen	51.0 nTPM
Stomach	13.5 nTPM
Adipose tissue	11.6 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	15.8 nTPM
Lung	19.0 nTPM
Bronchus	12.6 nTPM

Smooth muscle cells	35.9 nTPM
Pancreas	86.4 nTPM
Bronchus	55.8 nTPM
Ovary	49.0 nTPM
Prostate	32.8 nTPM
Endometrium	30.5 nTPM
Skin	30.3 nTPM
Breast	29.2 nTPM
Skeletal muscle	29.1 nTPM
Adipose tissue	23.6 nTPM
Esophagus	17.0 nTPM
Heart muscle	11.5 nTPM

T-cells	18.6 nTPM
PBMC	31.1 nTPM
Liver	25.2 nTPM
Endometrium	24.4 nTPM
Stomach	21.9 nTPM
Bone marrow	21.7 nTPM
Ovary	20.1 nTPM
Lung	19.7 nTPM
Colon	19.5 nTPM
Spleen	18.0 nTPM
Lymph node	16.7 nTPM
Skin	16.1 nTPM
Kidney	15.8 nTPM
Breast	14.7 nTPM
Prostate	14.2 nTPM
Adipose tissue	13.4 nTPM
Esophagus	13.1 nTPM
Skeletal muscle	11.2 nTPM

Basal keratinocytes	37.3 nTPM
Skin	37.3 nTPM

Basal prostatic cells	59.1 nTPM
Prostate	59.1 nTPM

Basal respiratory cells	45.8 nTPM
Bronchus	45.8 nTPM

Basal squamous epithelial cells	42.7 nTPM
Esophagus	42.7 nTPM

Undifferentiated cells	34.8 nTPM
Colon	47.3 nTPM
Small intestine	30.4 nTPM
Rectum	26.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC