Single cell type - MRPL43 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MRPL43
Gene descriptionⁱ Full gene name according to HGNC.	Mitochondrial ribosomal protein L43
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Ribosomal proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MRPL43 is part of cluster 66 Spermatocytes - Spermatogenesis with confidenceⁱ 1
507 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
C15orf61	Chromosome 15 open reading frame 61	0.6921	66
SMIM19	Small integral membrane protein 19	0.6542	66
CAPN11	Calpain 11	0.6280	66
TUSC1	Tumor suppressor candidate 1	0.6115	66
CYB5D2	Cytochrome b5 domain containing 2	0.6049	66
TMBIM4	Transmembrane BAX inhibitor motif containing 4	0.6035	66
COPRS	Coordinator of PRMT5 and differentiation stimulator	0.6030	66
THTPA	Thiamine triphosphatase	0.5980	66
METTL23	Methyltransferase like 23	0.5944	66
AARD	Alanine and arginine rich domain containing protein	0.5943	66
PSMG2	Proteasome assembly chaperone 2	0.5686	66
ZC2HC1C	Zinc finger C2HC-type containing 1C	0.5654	66
RPUSD3	RNA pseudouridine synthase D3	0.5634	66
CETN1	Centrin 1	0.5626	66
C1orf167	Chromosome 1 open reading frame 167	0.5625	66

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	84.3 nTPM
Breast	115.4 nTPM
Adipose tissue	53.3 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	49.6 nTPM
Lung	49.6 nTPM

Astrocytes	9.8 nTPM
Brain	9.8 nTPM

B-cells	64.5 nTPM
Liver	115.7 nTPM
Kidney	90.4 nTPM
PBMC	80.0 nTPM
Breast	69.6 nTPM
Stomach	58.5 nTPM
Colon	55.9 nTPM
Spleen	54.3 nTPM
Bone marrow	44.2 nTPM
Lymph node	44.1 nTPM
Adipose tissue	32.1 nTPM

Dendritic cells	63.7 nTPM
PBMC	75.7 nTPM
Breast	70.7 nTPM
Adipose tissue	44.6 nTPM

Endothelial cells	58.8 nTPM
Placenta	101.8 nTPM
Breast	81.2 nTPM
Ovary	77.0 nTPM
Testis	73.8 nTPM
Pancreas	69.5 nTPM
Liver	68.8 nTPM
Esophagus	65.6 nTPM
Skin	53.3 nTPM
Eye	49.3 nTPM
Skeletal muscle	47.4 nTPM
Endometrium	42.9 nTPM
Prostate	39.6 nTPM
Lung	28.1 nTPM
Heart muscle	25.5 nTPM

Fibroblasts	68.9 nTPM
Placenta	104.2 nTPM
Breast	99.7 nTPM
Adipose tissue	93.8 nTPM
Ovary	86.8 nTPM
Esophagus	82.5 nTPM
Stomach	62.4 nTPM
Skin	62.0 nTPM
Skeletal muscle	58.8 nTPM
Prostate	48.3 nTPM
Lung	34.7 nTPM
Heart muscle	25.1 nTPM

Intestinal goblet cells	77.7 nTPM
Colon	92.2 nTPM
Small intestine	72.1 nTPM
Rectum	68.9 nTPM

Macrophages	47.6 nTPM
Kidney	85.4 nTPM
Pancreas	81.7 nTPM
Ovary	68.5 nTPM
Breast	66.6 nTPM
Testis	51.7 nTPM
Lung	47.3 nTPM
Esophagus	42.5 nTPM
Endometrium	42.0 nTPM
Bone marrow	41.2 nTPM
Prostate	40.1 nTPM
Spleen	39.4 nTPM
Adipose tissue	37.7 nTPM
Skeletal muscle	35.4 nTPM
Stomach	35.1 nTPM
PBMC	0.0 nTPM

Paneth cells	77.4 nTPM
Rectum	95.8 nTPM
Small intestine	90.1 nTPM
Colon	46.1 nTPM

Plasma cells	70.8 nTPM
Spleen	120.3 nTPM
Bone marrow	84.1 nTPM
Stomach	75.9 nTPM
Esophagus	36.9 nTPM
Adipose tissue	36.7 nTPM

Respiratory ciliated cells	79.7 nTPM
Lung	86.0 nTPM
Bronchus	73.5 nTPM

Smooth muscle cells	82.2 nTPM
Breast	141.1 nTPM
Esophagus	114.7 nTPM
Pancreas	101.6 nTPM
Skin	87.9 nTPM
Ovary	85.3 nTPM
Adipose tissue	80.3 nTPM
Skeletal muscle	75.0 nTPM
Prostate	68.7 nTPM
Bronchus	67.9 nTPM
Endometrium	48.5 nTPM
Heart muscle	33.6 nTPM

T-cells	61.6 nTPM
Ovary	91.2 nTPM
Kidney	81.4 nTPM
Esophagus	78.6 nTPM
PBMC	75.8 nTPM
Liver	72.7 nTPM
Breast	72.3 nTPM
Prostate	66.3 nTPM
Bone marrow	64.7 nTPM
Spleen	59.7 nTPM
Stomach	58.0 nTPM
Colon	57.0 nTPM
Lymph node	54.3 nTPM
Adipose tissue	48.5 nTPM
Skin	47.5 nTPM
Lung	42.6 nTPM
Skeletal muscle	41.1 nTPM
Endometrium	34.8 nTPM

Basal keratinocytes	55.7 nTPM
Skin	55.7 nTPM

Basal prostatic cells	70.6 nTPM
Prostate	70.6 nTPM

Basal respiratory cells	97.2 nTPM
Bronchus	97.2 nTPM

Basal squamous epithelial cells	60.3 nTPM
Esophagus	60.3 nTPM

Undifferentiated cells	80.6 nTPM
Small intestine	87.8 nTPM
Rectum	84.6 nTPM
Colon	69.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC