Single cell type - RC3H2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RC3H2
Gene descriptionⁱ Full gene name according to HGNC.	Ring finger and CCCH-type domains 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endometrium - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RC3H2 is part of cluster 44 Endometrium - Transcription with confidenceⁱ 1
491 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
WDFY1	WD repeat and FYVE domain containing 1	0.5330	44
N4BP1	NEDD4 binding protein 1	0.5217	44
TAOK1	TAO kinase 1	0.5121	10
RALGAPB	Ral GTPase activating protein non-catalytic subunit beta	0.5042	44
DDX6	DEAD-box helicase 6	0.4809	24
PDS5A	PDS5 cohesin associated factor A	0.4770	59
MED1	Mediator complex subunit 1	0.4717	10
SERINC1	Serine incorporator 1	0.4688	24
WNK1	WNK lysine deficient protein kinase 1	0.4613	10
SACM1L	SAC1 like phosphatidylinositide phosphatase	0.4564	24
LYSMD3	LysM domain containing 3	0.4541	24
FMR1	FMRP translational regulator 1	0.4504	44
ASXL2	ASXL transcriptional regulator 2	0.4490	59
MAML1	Mastermind like transcriptional coactivator 1	0.4456	14
COPA	COPI coat complex subunit alpha	0.4452	65

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	33.8 nTPM
Adipose tissue	44.8 nTPM
Breast	22.9 nTPM

Alveolar cells type 1	41.7 nTPM
Lung	41.7 nTPM

Alveolar cells type 2	32.8 nTPM
Lung	32.8 nTPM

Astrocytes	20.9 nTPM
Brain	20.9 nTPM

B-cells	27.7 nTPM
Adipose tissue	48.2 nTPM
Stomach	40.0 nTPM
Spleen	38.4 nTPM
Colon	38.3 nTPM
Lymph node	30.4 nTPM
PBMC	24.3 nTPM
Bone marrow	22.9 nTPM
Breast	16.0 nTPM
Liver	13.8 nTPM
Kidney	4.8 nTPM

Dendritic cells	26.6 nTPM
Adipose tissue	54.8 nTPM
Breast	17.1 nTPM
PBMC	8.0 nTPM

Endothelial cells	28.3 nTPM
Lung	46.8 nTPM
Ovary	38.9 nTPM
Heart muscle	38.1 nTPM
Prostate	33.5 nTPM
Liver	31.2 nTPM
Esophagus	30.9 nTPM
Skeletal muscle	30.5 nTPM
Endometrium	29.4 nTPM
Eye	25.1 nTPM
Breast	23.1 nTPM
Testis	21.4 nTPM
Placenta	18.2 nTPM
Skin	17.9 nTPM
Pancreas	11.6 nTPM

Fibroblasts	18.4 nTPM
Adipose tissue	25.3 nTPM
Esophagus	22.0 nTPM
Heart muscle	21.6 nTPM
Skeletal muscle	21.0 nTPM
Ovary	21.0 nTPM
Prostate	20.9 nTPM
Stomach	16.3 nTPM
Lung	14.5 nTPM
Placenta	13.9 nTPM
Skin	13.0 nTPM
Breast	12.5 nTPM

Intestinal goblet cells	19.8 nTPM
Rectum	26.4 nTPM
Small intestine	23.9 nTPM
Colon	9.3 nTPM

Macrophages	21.4 nTPM
Spleen	45.6 nTPM
Adipose tissue	35.5 nTPM
Bone marrow	31.2 nTPM
Lung	29.7 nTPM
Skeletal muscle	27.3 nTPM
Esophagus	26.8 nTPM
Ovary	25.3 nTPM
Prostate	17.2 nTPM
Kidney	15.8 nTPM
Endometrium	15.7 nTPM
Stomach	14.7 nTPM
Testis	14.5 nTPM
Breast	13.7 nTPM
Pancreas	7.7 nTPM
PBMC	0.0 nTPM

Paneth cells	9.0 nTPM
Rectum	19.9 nTPM
Small intestine	3.7 nTPM
Colon	3.3 nTPM

Plasma cells	22.5 nTPM
Adipose tissue	38.8 nTPM
Bone marrow	23.0 nTPM
Stomach	20.7 nTPM
Spleen	17.9 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	17.7 nTPM
Bronchus	22.3 nTPM
Lung	13.1 nTPM

Smooth muscle cells	24.1 nTPM
Heart muscle	35.1 nTPM
Adipose tissue	32.8 nTPM
Bronchus	32.2 nTPM
Endometrium	29.5 nTPM
Ovary	27.8 nTPM
Skeletal muscle	22.4 nTPM
Esophagus	20.1 nTPM
Prostate	17.5 nTPM
Skin	17.5 nTPM
Breast	15.3 nTPM
Pancreas	14.6 nTPM

T-cells	28.8 nTPM
Adipose tissue	54.6 nTPM
Stomach	41.6 nTPM
Spleen	41.4 nTPM
Bone marrow	40.6 nTPM
Skin	34.5 nTPM
Colon	32.8 nTPM
Endometrium	30.6 nTPM
Liver	29.3 nTPM
Skeletal muscle	29.3 nTPM
Lymph node	29.3 nTPM
PBMC	26.5 nTPM
Breast	22.2 nTPM
Lung	19.7 nTPM
Esophagus	19.7 nTPM
Prostate	19.0 nTPM
Ovary	11.1 nTPM
Kidney	7.5 nTPM

Basal keratinocytes	11.0 nTPM
Skin	11.0 nTPM

Basal prostatic cells	13.6 nTPM
Prostate	13.6 nTPM

Basal respiratory cells	20.0 nTPM
Bronchus	20.0 nTPM

Basal squamous epithelial cells	20.5 nTPM
Esophagus	20.5 nTPM

Undifferentiated cells	14.7 nTPM
Rectum	19.8 nTPM
Small intestine	13.9 nTPM
Colon	10.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC