Single cell type - ATP2B4 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATP2B4
Gene descriptionⁱ Full gene name according to HGNC.	ATPase plasma membrane Ca2+ transporting 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes FDA approved drug targets Metabolic proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Adipocytes & Endothelial cells - Angiogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocyte precursor cells, Adipocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, SuSa)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocyte precursor cells, Adipocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ATP2B4 is part of cluster 14 Adipocytes & Endothelial cells - Angiogenesis with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CAMSAP2	Calmodulin regulated spectrin associated protein family member 2	0.5184	68
JAG2	Jagged canonical Notch ligand 2	0.5112	14
CAV1	Caveolin 1	0.4639	14
NRP1	Neuropilin 1	0.4603	14
ATOH8	Atonal bHLH transcription factor 8	0.4475	14
MAP3K4	Mitogen-activated protein kinase kinase kinase 4	0.4410	44
TPO	Thyroid peroxidase	0.4396	14
SOX17	SRY-box transcription factor 17	0.4350	44
ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif 1	0.4320	48
TACC1	Transforming acidic coiled-coil containing protein 1	0.4294	14
ENDOU	Endonuclease, poly(U) specific	0.4287	44
MAP3K6	Mitogen-activated protein kinase kinase kinase 6	0.4280	14
APOLD1	Apolipoprotein L domain containing 1	0.4278	14
EPAS1	Endothelial PAS domain protein 1	0.4264	14
ZEB1	Zinc finger E-box binding homeobox 1	0.4256	68

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	89.8 nTPM
Lung	89.8 nTPM

Alveolar cells type 2	68.2 nTPM
Lung	68.2 nTPM

Astrocytes	127.6 nTPM
Brain	127.6 nTPM

B-cells	9.9 nTPM
Stomach	14.5 nTPM
Kidney	14.3 nTPM
Adipose tissue	14.1 nTPM
Lymph node	12.4 nTPM
Liver	11.8 nTPM
Breast	9.4 nTPM
Colon	8.0 nTPM
Spleen	5.2 nTPM
Bone marrow	4.9 nTPM
PBMC	4.3 nTPM

Basal keratinocytes	97.1 nTPM
Skin	97.1 nTPM

Adipocytes	171.6 nTPM
Adipose tissue	225.9 nTPM
Breast	117.3 nTPM

Dendritic cells	56.2 nTPM
Adipose tissue	70.8 nTPM
Breast	62.0 nTPM
PBMC	35.8 nTPM

Endothelial cells	67.6 nTPM
Skeletal muscle	184.3 nTPM
Heart muscle	125.6 nTPM
Lung	96.7 nTPM
Ovary	94.9 nTPM
Esophagus	77.1 nTPM
Prostate	63.8 nTPM
Breast	60.0 nTPM
Endometrium	51.0 nTPM
Skin	43.6 nTPM
Eye	42.1 nTPM
Liver	40.3 nTPM
Placenta	30.7 nTPM
Testis	24.6 nTPM
Pancreas	11.6 nTPM

Fibroblasts	56.0 nTPM
Heart muscle	107.1 nTPM
Adipose tissue	90.4 nTPM
Skin	74.2 nTPM
Skeletal muscle	73.8 nTPM
Stomach	57.9 nTPM
Lung	52.5 nTPM
Esophagus	44.8 nTPM
Breast	36.5 nTPM
Prostate	30.4 nTPM
Placenta	28.2 nTPM
Ovary	20.6 nTPM

Intestinal goblet cells	2.4 nTPM
Small intestine	3.8 nTPM
Colon	2.2 nTPM
Rectum	1.3 nTPM

Macrophages	20.4 nTPM
Adipose tissue	43.1 nTPM
Skeletal muscle	39.5 nTPM
Esophagus	34.6 nTPM
Endometrium	28.0 nTPM
Ovary	26.8 nTPM
Spleen	21.8 nTPM
Bone marrow	20.0 nTPM
Testis	17.4 nTPM
Lung	16.6 nTPM
Breast	16.1 nTPM
Stomach	14.7 nTPM
Kidney	11.4 nTPM
Prostate	8.1 nTPM
Pancreas	7.7 nTPM
PBMC	0.0 nTPM

Paneth cells	11.1 nTPM
Colon	16.5 nTPM
Rectum	13.2 nTPM
Small intestine	3.7 nTPM

Plasma cells	27.6 nTPM
Adipose tissue	65.2 nTPM
Esophagus	24.6 nTPM
Stomach	20.6 nTPM
Bone marrow	14.8 nTPM
Spleen	12.7 nTPM

Respiratory ciliated cells	39.7 nTPM
Bronchus	41.4 nTPM
Lung	37.9 nTPM

Smooth muscle cells	81.2 nTPM
Heart muscle	161.3 nTPM
Esophagus	136.5 nTPM
Endometrium	116.3 nTPM
Skin	101.2 nTPM
Adipose tissue	92.1 nTPM
Breast	76.9 nTPM
Skeletal muscle	72.7 nTPM
Prostate	64.1 nTPM
Ovary	39.8 nTPM
Pancreas	23.6 nTPM
Bronchus	8.5 nTPM

Cholangiocytes	7.2 nTPM
Liver	7.2 nTPM

Collecting duct cells	18.4 nTPM
Kidney	18.4 nTPM

Cone photoreceptor cells	2.1 nTPM
Eye	2.1 nTPM

Cytotrophoblasts	27.9 nTPM
Placenta	27.9 nTPM

T-cells	59.7 nTPM
Skeletal muscle	95.2 nTPM
Stomach	89.3 nTPM
Lung	82.0 nTPM
Adipose tissue	81.8 nTPM
Esophagus	78.6 nTPM
Bone marrow	66.3 nTPM
Spleen	66.0 nTPM
Endometrium	65.5 nTPM
Colon	53.7 nTPM
Skin	53.4 nTPM
Lymph node	51.6 nTPM
Ovary	51.2 nTPM
Breast	48.4 nTPM
Liver	41.2 nTPM
Kidney	39.1 nTPM
PBMC	33.5 nTPM
Prostate	19.0 nTPM

Undifferentiated cells	3.3 nTPM
Small intestine	6.2 nTPM
Rectum	3.0 nTPM
Colon	0.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC