Single cell type - MXD1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MXD1
Gene descriptionⁱ Full gene name according to HGNC.	MAX dimerization protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal enterocytes, Paneth cells, Langerhans cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (hTERT-HME1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal enterocytes, Paneth cells, Langerhans cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MXD1 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CLCA4	Chloride channel accessory 4	0.7650	53
MYO15B	Myosin XVB	0.7439	53
MIER3	MIER family member 3	0.7422	53
CLDN23	Claudin 23	0.7366	53
CDA	Cytidine deaminase	0.7317	53
SIRT6	Sirtuin 6	0.7274	53
PLCD1	Phospholipase C delta 1	0.7274	53
TRIM31	Tripartite motif containing 31	0.7266	53
TICAM1	Toll like receptor adaptor molecule 1	0.7194	53
CEACAM7	CEA cell adhesion molecule 7	0.7190	53
AQP8	Aquaporin 8	0.7183	53
CASP5	Caspase 5	0.7115	53
ARRDC4	Arrestin domain containing 4	0.7090	53
SECTM1	Secreted and transmembrane 1	0.7038	53
UPP1	Uridine phosphorylase 1	0.7015	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	18.0 nTPM
Adipose tissue	18.7 nTPM
Breast	17.4 nTPM

Alveolar cells type 1	38.5 nTPM
Lung	38.5 nTPM

Alveolar cells type 2	23.7 nTPM
Lung	23.7 nTPM

Astrocytes	16.0 nTPM
Brain	16.0 nTPM

B-cells	25.4 nTPM
Colon	49.5 nTPM
Breast	48.1 nTPM
Adipose tissue	38.6 nTPM
Kidney	28.5 nTPM
Lymph node	24.3 nTPM
Stomach	21.4 nTPM
Spleen	18.0 nTPM
Bone marrow	12.3 nTPM
Liver	9.2 nTPM
PBMC	4.3 nTPM

Dendritic cells	46.2 nTPM
Adipose tissue	74.2 nTPM
Breast	52.5 nTPM
PBMC	12.0 nTPM

Endothelial cells	12.0 nTPM
Prostate	20.3 nTPM
Skin	19.8 nTPM
Breast	19.8 nTPM
Endometrium	19.2 nTPM
Eye	18.6 nTPM
Skeletal muscle	15.5 nTPM
Esophagus	13.9 nTPM
Liver	9.2 nTPM
Heart muscle	8.7 nTPM
Ovary	7.9 nTPM
Placenta	5.1 nTPM
Pancreas	3.9 nTPM
Testis	3.5 nTPM
Lung	3.1 nTPM

Enteroendocrine cells	97.5 nTPM
Colon	163.4 nTPM
Rectum	31.6 nTPM

Fibroblasts	17.9 nTPM
Lung	43.6 nTPM
Prostate	30.8 nTPM
Skin	26.3 nTPM
Esophagus	23.1 nTPM
Breast	18.9 nTPM
Adipose tissue	14.3 nTPM
Stomach	11.9 nTPM
Heart muscle	11.1 nTPM
Skeletal muscle	10.2 nTPM
Placenta	4.4 nTPM
Ovary	2.7 nTPM

Intestinal goblet cells	155.5 nTPM
Colon	290.2 nTPM
Small intestine	103.6 nTPM
Rectum	72.7 nTPM

Macrophages	190.8 nTPM
Adipose tissue	647.9 nTPM
Stomach	430.8 nTPM
Prostate	314.1 nTPM
Spleen	267.5 nTPM
Skeletal muscle	260.6 nTPM
Endometrium	183.1 nTPM
Lung	144.2 nTPM
PBMC	122.7 nTPM
Bone marrow	103.7 nTPM
Kidney	86.2 nTPM
Esophagus	85.0 nTPM
Pancreas	71.5 nTPM
Breast	67.2 nTPM
Ovary	52.9 nTPM
Testis	25.0 nTPM

Paneth cells	369.6 nTPM
Colon	932.1 nTPM
Small intestine	97.6 nTPM
Rectum	79.2 nTPM

Plasma cells	33.1 nTPM
Stomach	59.9 nTPM
Adipose tissue	54.9 nTPM
Esophagus	24.6 nTPM
Spleen	17.9 nTPM
Bone marrow	8.2 nTPM

Respiratory ciliated cells	24.2 nTPM
Bronchus	36.7 nTPM
Lung	11.7 nTPM

Smooth muscle cells	18.3 nTPM
Prostate	33.1 nTPM
Heart muscle	31.6 nTPM
Skin	25.8 nTPM
Adipose tissue	23.5 nTPM
Endometrium	22.2 nTPM
Breast	16.1 nTPM
Bronchus	13.2 nTPM
Esophagus	12.4 nTPM
Skeletal muscle	11.8 nTPM
Ovary	6.3 nTPM
Pancreas	5.9 nTPM

Basal keratinocytes	25.7 nTPM
Skin	25.7 nTPM

Basal respiratory cells	61.8 nTPM
Bronchus	61.8 nTPM

Cholangiocytes	10.0 nTPM
Liver	10.0 nTPM

Collecting duct cells	1.8 nTPM
Kidney	1.8 nTPM

T-cells	30.3 nTPM
Adipose tissue	55.8 nTPM
Breast	52.8 nTPM
Prostate	52.1 nTPM
Esophagus	45.9 nTPM
Colon	45.1 nTPM
Endometrium	44.3 nTPM
Skin	37.3 nTPM
Skeletal muscle	32.6 nTPM
Lung	30.4 nTPM
Spleen	26.7 nTPM
Lymph node	18.8 nTPM
Stomach	17.4 nTPM
Kidney	15.1 nTPM
Bone marrow	13.9 nTPM
Liver	11.7 nTPM
PBMC	8.5 nTPM
Ovary	6.7 nTPM

Undifferentiated cells	65.9 nTPM
Colon	140.4 nTPM
Rectum	36.3 nTPM
Small intestine	21.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC