Single cell type - ACAA1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACAA1
Gene descriptionⁱ Full gene name according to HGNC.	Acetyl-CoA acyltransferase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes FDA approved drug targets Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Hepatocytes, Proximal enterocytes, Distal enterocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (OE19, SK-BR-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Hepatocytes, Proximal enterocytes, Distal enterocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ACAA1 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ACAA2	Acetyl-CoA acyltransferase 2	0.8724	67
ASS1	Argininosuccinate synthase 1	0.7512	67
PCK1	Phosphoenolpyruvate carboxykinase 1	0.7130	67
TPMT	Thiopurine S-methyltransferase	0.7113	67
ECHS1	Enoyl-CoA hydratase, short chain 1	0.7069	67
TINAG	Tubulointerstitial nephritis antigen	0.6965	67
CRYL1	Crystallin lambda 1	0.6844	67
MSRB1	Methionine sulfoxide reductase B1	0.6779	67
APOM	Apolipoprotein M	0.6591	67
GLTPD2	Glycolipid transfer protein domain containing 2	0.6584	67
LDHD	Lactate dehydrogenase D	0.6546	53
HPD	4-hydroxyphenylpyruvate dioxygenase	0.6519	67
DAO	D-amino acid oxidase	0.6459	67
SLC16A9	Solute carrier family 16 member 9	0.6456	67
GLYATL1	Glycine-N-acyltransferase like 1	0.6415	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	30.7 nTPM
Breast	32.5 nTPM
Adipose tissue	29.0 nTPM

Alveolar cells type 1	41.7 nTPM
Lung	41.7 nTPM

Alveolar cells type 2	38.7 nTPM
Lung	38.7 nTPM

Astrocytes	50.6 nTPM
Brain	50.6 nTPM

B-cells	45.6 nTPM
PBMC	62.8 nTPM
Liver	55.3 nTPM
Kidney	52.4 nTPM
Bone marrow	46.6 nTPM
Spleen	45.0 nTPM
Colon	44.8 nTPM
Breast	44.1 nTPM
Stomach	35.4 nTPM
Lymph node	35.3 nTPM
Adipose tissue	34.1 nTPM

Dendritic cells	61.7 nTPM
PBMC	71.8 nTPM
Breast	62.7 nTPM
Adipose tissue	50.7 nTPM

Endothelial cells	25.4 nTPM
Placenta	39.8 nTPM
Liver	38.5 nTPM
Ovary	35.3 nTPM
Pancreas	34.7 nTPM
Testis	34.4 nTPM
Skin	29.2 nTPM
Breast	27.8 nTPM
Eye	25.9 nTPM
Endometrium	24.2 nTPM
Skeletal muscle	23.0 nTPM
Esophagus	21.7 nTPM
Prostate	19.2 nTPM
Heart muscle	1.5 nTPM
Lung	0.0 nTPM

Fibroblasts	34.4 nTPM
Ovary	93.5 nTPM
Adipose tissue	40.6 nTPM
Skin	36.5 nTPM
Breast	36.4 nTPM
Placenta	35.9 nTPM
Esophagus	31.1 nTPM
Skeletal muscle	30.7 nTPM
Lung	27.9 nTPM
Prostate	23.0 nTPM
Stomach	22.3 nTPM
Heart muscle	1.0 nTPM

Intestinal goblet cells	73.1 nTPM
Colon	93.0 nTPM
Small intestine	67.2 nTPM
Rectum	59.2 nTPM

Macrophages	83.2 nTPM
Kidney	149.0 nTPM
Stomach	143.6 nTPM
Bone marrow	105.0 nTPM
Pancreas	104.7 nTPM
Adipose tissue	90.2 nTPM
Skeletal muscle	78.4 nTPM
Breast	78.4 nTPM
Prostate	75.7 nTPM
Ovary	72.1 nTPM
Esophagus	69.3 nTPM
Spleen	67.4 nTPM
Endometrium	61.5 nTPM
Testis	55.8 nTPM
Lung	55.6 nTPM
PBMC	40.9 nTPM

Paneth cells	270.6 nTPM
Colon	583.0 nTPM
Small intestine	131.5 nTPM
Rectum	97.3 nTPM

Plasma cells	44.5 nTPM
Spleen	52.8 nTPM
Adipose tissue	49.7 nTPM
Stomach	49.5 nTPM
Bone marrow	46.2 nTPM
Esophagus	24.6 nTPM

Respiratory ciliated cells	26.3 nTPM
Bronchus	33.7 nTPM
Lung	19.0 nTPM

Smooth muscle cells	27.4 nTPM
Pancreas	45.4 nTPM
Ovary	40.0 nTPM
Breast	36.7 nTPM
Prostate	31.2 nTPM
Bronchus	28.8 nTPM
Skin	27.1 nTPM
Adipose tissue	26.7 nTPM
Endometrium	23.3 nTPM
Esophagus	21.7 nTPM
Skeletal muscle	18.3 nTPM
Heart muscle	2.5 nTPM

T-cells	44.4 nTPM
Kidney	83.5 nTPM
Ovary	71.2 nTPM
Liver	64.5 nTPM
Breast	51.8 nTPM
Bone marrow	49.0 nTPM
PBMC	46.5 nTPM
Skin	46.5 nTPM
Stomach	44.3 nTPM
Lymph node	42.7 nTPM
Spleen	42.3 nTPM
Skeletal muscle	40.3 nTPM
Colon	38.5 nTPM
Endometrium	38.4 nTPM
Adipose tissue	36.4 nTPM
Esophagus	32.8 nTPM
Lung	16.7 nTPM
Prostate	9.5 nTPM

Basal keratinocytes	33.3 nTPM
Skin	33.3 nTPM

Basal prostatic cells	56.5 nTPM
Prostate	56.5 nTPM

Basal respiratory cells	57.6 nTPM
Bronchus	57.6 nTPM

Cholangiocytes	98.7 nTPM
Liver	98.7 nTPM

Undifferentiated cells	84.3 nTPM
Colon	122.1 nTPM
Rectum	72.2 nTPM
Small intestine	58.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC