Single cell type - MRPS24 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MRPS24
Gene descriptionⁱ Full gene name according to HGNC.	Mitochondrial ribosomal protein S24
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Ribosomal proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Squamous epithelial cells, Plasma cells, Basal squamous epithelial cells, Gastric mucus-secreting cells, Erythroid cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Squamous epithelial cells, Plasma cells, Basal squamous epithelial cells, Gastric mucus-secreting cells, Erythroid cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MRPS24 is part of cluster 59 Non-specific - Transcription with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NME2	NME/NM23 nucleoside diphosphate kinase 2	0.9608	61
PDF	Peptide deformylase, mitochondrial	0.9397	59
PAM16	Presequence translocase associated motor 16	0.9121	59
PRICKLE4	Prickle planar cell polarity protein 4	0.8347	59
GTF2H4	General transcription factor IIH subunit 4	0.8109	59
LTB4R2	Leukotriene B4 receptor 2	0.7941	59
WBP1	WW domain binding protein 1	0.7799	59
C11orf98	Chromosome 11 open reading frame 98	0.7797	59
ATP6V0C	ATPase H+ transporting V0 subunit c	0.7774	59
ZNF749	Zinc finger protein 749	0.7440	61
RNASEK	Ribonuclease K	0.7430	59
TRAPPC5	Trafficking protein particle complex 5	0.7320	59
BCKDHA	Branched chain keto acid dehydrogenase E1 subunit alpha	0.7182	59
EML3	EMAP like 3	0.6978	61
MRPL38	Mitochondrial ribosomal protein L38	0.6973	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	1.2 nTPM
Adipose tissue	1.2 nTPM
Breast	1.2 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	19.1 nTPM
Lung	19.1 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	24.1 nTPM
Spleen	66.5 nTPM
Bone marrow	66.2 nTPM
Stomach	49.5 nTPM
Lymph node	41.0 nTPM
Liver	8.3 nTPM
Colon	4.8 nTPM
PBMC	2.8 nTPM
Breast	1.3 nTPM
Adipose tissue	1.0 nTPM
Kidney	0.0 nTPM

Basal squamous epithelial cells	109.3 nTPM
Esophagus	109.3 nTPM

Dendritic cells	2.9 nTPM
PBMC	4.0 nTPM
Adipose tissue	2.6 nTPM
Breast	2.2 nTPM

Endothelial cells	7.8 nTPM
Esophagus	72.8 nTPM
Endometrium	6.5 nTPM
Lung	6.2 nTPM
Liver	5.5 nTPM
Breast	5.2 nTPM
Skin	4.1 nTPM
Prostate	2.0 nTPM
Placenta	1.7 nTPM
Skeletal muscle	1.7 nTPM
Eye	1.6 nTPM
Testis	0.9 nTPM
Heart muscle	0.8 nTPM
Ovary	0.5 nTPM
Pancreas	0.0 nTPM

Fibroblasts	20.4 nTPM
Esophagus	92.7 nTPM
Stomach	66.9 nTPM
Lung	36.9 nTPM
Skin	13.9 nTPM
Prostate	3.8 nTPM
Skeletal muscle	3.4 nTPM
Breast	2.7 nTPM
Adipose tissue	1.5 nTPM
Placenta	1.4 nTPM
Heart muscle	1.0 nTPM
Ovary	0.5 nTPM

Intestinal goblet cells	1.5 nTPM
Colon	2.2 nTPM
Rectum	1.4 nTPM
Small intestine	1.0 nTPM

Macrophages	24.4 nTPM
Spleen	83.9 nTPM
Esophagus	78.7 nTPM
Bone marrow	74.9 nTPM
Stomach	70.3 nTPM
Lung	15.0 nTPM
Endometrium	13.3 nTPM
Pancreas	7.7 nTPM
Prostate	4.6 nTPM
Skeletal muscle	4.5 nTPM
Breast	4.5 nTPM
Testis	2.9 nTPM
Ovary	2.7 nTPM
Adipose tissue	2.6 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM

Paneth cells	0.7 nTPM
Rectum	2.1 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	184.7 nTPM
Spleen	280.9 nTPM
Esophagus	227.8 nTPM
Bone marrow	219.2 nTPM
Stomach	191.5 nTPM
Adipose tissue	3.9 nTPM

Respiratory ciliated cells	21.9 nTPM
Lung	42.3 nTPM
Bronchus	1.6 nTPM

Smooth muscle cells	13.8 nTPM
Esophagus	102.3 nTPM
Heart muscle	11.2 nTPM
Endometrium	10.7 nTPM
Skin	7.3 nTPM
Pancreas	5.3 nTPM
Prostate	4.3 nTPM
Skeletal muscle	3.1 nTPM
Breast	2.3 nTPM
Adipose tissue	2.1 nTPM
Bronchus	1.9 nTPM
Ovary	1.4 nTPM

Cholangiocytes	8.6 nTPM
Liver	8.6 nTPM

Early spermatids	1.8 nTPM
Testis	1.8 nTPM

Endometrial stromal cells	16.5 nTPM
Endometrium	16.5 nTPM

T-cells	19.4 nTPM
Bone marrow	64.7 nTPM
Spleen	61.3 nTPM
Stomach	59.6 nTPM
Lymph node	47.5 nTPM
Esophagus	32.8 nTPM
Lung	21.3 nTPM
Liver	7.0 nTPM
Ovary	6.7 nTPM
Skeletal muscle	4.9 nTPM
Prostate	4.7 nTPM
Endometrium	4.4 nTPM
Colon	3.8 nTPM
PBMC	3.8 nTPM
Breast	3.1 nTPM
Adipose tissue	2.6 nTPM
Skin	2.3 nTPM
Kidney	0.0 nTPM

Undifferentiated cells	2.1 nTPM
Rectum	3.0 nTPM
Small intestine	1.7 nTPM
Colon	1.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC