Single cell type - ST3GAL6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ST3GAL6
Gene descriptionⁱ Full gene name according to HGNC.	ST3 beta-galactoside alpha-2,3-sialyltransferase 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Ciliated cells - Cilium organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocyte precursor cells, Microglial cells, Endometrial ciliated cells, Hepatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil, eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Group enriched (RPMI-8226, SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocyte precursor cells, Microglial cells, Endometrial ciliated cells, Hepatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ST3GAL6 is part of cluster 49 Ciliated cells - Cilium organization with confidenceⁱ 1
457 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PCCA	Propionyl-CoA carboxylase subunit alpha	0.5104	68
ANAPC4	Anaphase promoting complex subunit 4	0.5095	49
GLDC	Glycine decarboxylase	0.5001	47
CRISPLD1	Cysteine rich secretory protein LCCL domain containing 1	0.4977	44
BBS9	Bardet-Biedl syndrome 9	0.4946	42
CFAP298	Cilia and flagella associated protein 298	0.4769	49
MB21D2	Mab-21 domain containing 2	0.4672	18
CEP83	Centrosomal protein 83	0.4658	49
MPC1L	Mitochondrial pyruvate carrier 1 like	0.4626	49
KCNK13	Potassium two pore domain channel subfamily K member 13	0.4557	10
CCDC146	Coiled-coil domain containing 146	0.4533	49
ARGFX	Arginine-fifty homeobox	0.4532	8
OR6C70	Olfactory receptor family 6 subfamily C member 70	0.4492	21
SCGB1D4	Secretoglobin family 1D member 4	0.4486	49
NLGN4X	Neuroligin 4 X-linked	0.4472	68

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	10.1 nTPM
Adipose tissue	11.3 nTPM
Breast	9.0 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	35.2 nTPM
Lung	35.2 nTPM

Astrocytes	2.3 nTPM
Brain	2.3 nTPM

B-cells	2.3 nTPM
Breast	12.1 nTPM
Colon	4.8 nTPM
PBMC	2.8 nTPM
Liver	2.5 nTPM
Lymph node	0.8 nTPM
Spleen	0.3 nTPM
Kidney	0.0 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Dendritic cells	0.0 nTPM
Adipose tissue	0.1 nTPM
PBMC	0.0 nTPM
Breast	0.0 nTPM

Endothelial cells	20.2 nTPM
Prostate	95.6 nTPM
Pancreas	42.5 nTPM
Eye	29.9 nTPM
Ovary	26.1 nTPM
Heart muscle	15.1 nTPM
Testis	14.5 nTPM
Skin	10.8 nTPM
Esophagus	10.8 nTPM
Breast	8.8 nTPM
Liver	8.2 nTPM
Endometrium	7.7 nTPM
Skeletal muscle	7.3 nTPM
Placenta	5.7 nTPM
Lung	0.0 nTPM

Fibroblasts	3.8 nTPM
Heart muscle	7.9 nTPM
Skeletal muscle	6.4 nTPM
Esophagus	4.9 nTPM
Placenta	4.6 nTPM
Stomach	4.4 nTPM
Prostate	3.4 nTPM
Breast	3.3 nTPM
Adipose tissue	2.9 nTPM
Skin	2.1 nTPM
Lung	1.2 nTPM
Ovary	0.4 nTPM

Intestinal goblet cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Macrophages	38.4 nTPM
Prostate	105.5 nTPM
Endometrium	72.4 nTPM
Breast	72.3 nTPM
Testis	63.9 nTPM
Esophagus	42.5 nTPM
Pancreas	40.8 nTPM
Lung	31.4 nTPM
Adipose tissue	25.9 nTPM
Ovary	24.4 nTPM
Skeletal muscle	20.8 nTPM
Bone marrow	18.8 nTPM
Kidney	15.8 nTPM
Stomach	14.7 nTPM
PBMC	13.6 nTPM
Spleen	12.5 nTPM

Paneth cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	18.0 nTPM
Esophagus	61.7 nTPM
Stomach	20.9 nTPM
Spleen	4.0 nTPM
Adipose tissue	3.3 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	27.5 nTPM
Lung	35.0 nTPM
Bronchus	20.1 nTPM

Smooth muscle cells	2.2 nTPM
Heart muscle	4.3 nTPM
Skin	3.1 nTPM
Bronchus	2.9 nTPM
Endometrium	2.7 nTPM
Skeletal muscle	2.4 nTPM
Pancreas	2.3 nTPM
Ovary	2.2 nTPM
Breast	1.7 nTPM
Adipose tissue	1.4 nTPM
Prostate	1.3 nTPM
Esophagus	0.0 nTPM

T-cells	2.0 nTPM
Lung	15.2 nTPM
Prostate	9.5 nTPM
Endometrium	4.6 nTPM
Skin	1.4 nTPM
Breast	1.0 nTPM
Liver	0.9 nTPM
PBMC	0.8 nTPM
Skeletal muscle	0.5 nTPM
Adipose tissue	0.1 nTPM
Stomach	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Basal keratinocytes	11.5 nTPM
Skin	11.5 nTPM

Basal prostatic cells	2.6 nTPM
Prostate	2.6 nTPM

Basal respiratory cells	7.0 nTPM
Bronchus	7.0 nTPM

Collecting duct cells	3.7 nTPM
Kidney	3.7 nTPM

Undifferentiated cells	0.3 nTPM
Colon	0.7 nTPM
Rectum	0.1 nTPM
Small intestine	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC