Single cell type - ATP2C2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATP2C2
Gene descriptionⁱ Full gene name according to HGNC.	ATPase secretory pathway Ca2+ transporting 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes FDA approved drug targets Metabolic proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Intestinal goblet cells, Respiratory ciliated cells, Undifferentiated cells, Oligodendrocyte precursor cells, Alveolar cells type 2, Club cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (MCF7, OE19, RT4, SK-BR-3, T-47d)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Intestinal goblet cells, Respiratory ciliated cells, Undifferentiated cells, Oligodendrocyte precursor cells, Alveolar cells type 2, Club cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ATP2C2 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NOXO1	NADPH oxidase organizer 1	0.6873	53
MUC4	Mucin 4, cell surface associated	0.6757	26
ARHGEF38	Rho guanine nucleotide exchange factor 38	0.6689	35
AGR2	Anterior gradient 2, protein disulphide isomerase family member	0.6669	27
C9orf152	Chromosome 9 open reading frame 152	0.6217	27
NANS	N-acetylneuraminate synthase	0.6155	53
MUC5B	Mucin 5B, oligomeric mucus/gel-forming	0.6062	53
ST6GALNAC1	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	0.5997	27
ERN2	Endoplasmic reticulum to nucleus signaling 2	0.5988	27
TMCO4	Transmembrane and coiled-coil domains 4	0.5963	53
RETNLB	Resistin like beta	0.5931	27
NUPR1	Nuclear protein 1, transcriptional regulator	0.5821	26
LEFTY1	Left-right determination factor 1	0.5755	53
PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B	0.5755	53
CWH43	Cell wall biogenesis 43 C-terminal homolog	0.5735	44

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	0.0 nTPM
Breast	0.1 nTPM
Adipose tissue	0.0 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Astrocytes	4.2 nTPM
Brain	4.2 nTPM

B-cells	0.0 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Breast	0.0 nTPM

Basal keratinocytes	0.6 nTPM
Skin	0.6 nTPM

Dendritic cells	0.1 nTPM
Breast	0.4 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM

Endothelial cells	0.7 nTPM
Pancreas	3.9 nTPM
Endometrium	1.7 nTPM
Heart muscle	1.1 nTPM
Placenta	1.1 nTPM
Prostate	0.7 nTPM
Ovary	0.4 nTPM
Breast	0.4 nTPM
Skin	0.2 nTPM
Skeletal muscle	0.1 nTPM
Eye	0.0 nTPM
Liver	0.0 nTPM
Lung	0.0 nTPM
Testis	0.0 nTPM
Esophagus	0.0 nTPM

Fibroblasts	0.5 nTPM
Lung	2.2 nTPM
Placenta	1.1 nTPM
Skin	0.7 nTPM
Breast	0.4 nTPM
Heart muscle	0.2 nTPM
Prostate	0.2 nTPM
Skeletal muscle	0.1 nTPM
Ovary	0.1 nTPM
Adipose tissue	0.1 nTPM
Esophagus	0.0 nTPM
Stomach	0.0 nTPM

Intestinal goblet cells	82.3 nTPM
Colon	121.5 nTPM
Rectum	75.1 nTPM
Small intestine	50.4 nTPM

Macrophages	0.6 nTPM
Prostate	3.4 nTPM
Endometrium	2.4 nTPM
Lung	0.9 nTPM
Kidney	0.8 nTPM
Breast	0.7 nTPM
Testis	0.6 nTPM
Skeletal muscle	0.2 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	29.2 nTPM
Rectum	56.6 nTPM
Colon	19.7 nTPM
Small intestine	11.3 nTPM

Plasma cells	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	78.2 nTPM
Lung	78.7 nTPM
Bronchus	77.7 nTPM

Smooth muscle cells	1.8 nTPM
Bronchus	12.2 nTPM
Endometrium	3.2 nTPM
Prostate	1.5 nTPM
Skin	0.7 nTPM
Heart muscle	0.6 nTPM
Breast	0.5 nTPM
Skeletal muscle	0.3 nTPM
Pancreas	0.1 nTPM
Ovary	0.1 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

T-cells	0.9 nTPM
Lung	6.1 nTPM
Colon	3.8 nTPM
Endometrium	2.7 nTPM
Kidney	0.7 nTPM
Liver	0.7 nTPM
PBMC	0.4 nTPM
Breast	0.4 nTPM
Prostate	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Cholangiocytes	5.7 nTPM
Liver	5.7 nTPM

Cytotrophoblasts	2.0 nTPM
Placenta	2.0 nTPM

Distal enterocytes	44.4 nTPM
Colon	56.9 nTPM
Rectum	31.9 nTPM

Endometrial stromal cells	2.5 nTPM
Endometrium	2.5 nTPM

Undifferentiated cells	77.1 nTPM
Colon	104.7 nTPM
Rectum	82.3 nTPM
Small intestine	44.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC