Single cell type - HIPK2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HIPK2
Gene descriptionⁱ Full gene name according to HGNC.	Homeodomain interacting protein kinase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HDLM-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

HIPK2 is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FOLH1	Folate hydrolase 1	0.5103	42
RPRD1B	Regulation of nuclear pre-mRNA domain containing 1B	0.4941	35
ELL2	Elongation factor for RNA polymerase II 2	0.4441	41
ZNF189	Zinc finger protein 189	0.4398	42
PDE1C	Phosphodiesterase 1C	0.4317	42
SHROOM4	Shroom family member 4	0.4315	42
GPR62	G protein-coupled receptor 62	0.4304	42
ADAM10	ADAM metallopeptidase domain 10	0.4232	42
PDE4B	Phosphodiesterase 4B	0.4178	42
KCNJ2	Potassium inwardly rectifying channel subfamily J member 2	0.4169	62
DICER1	Dicer 1, ribonuclease III	0.4108	19
SH3BP4	SH3 domain binding protein 4	0.4090	35
TMEM165	Transmembrane protein 165	0.4068	22
ENPP4	Ectonucleotide pyrophosphatase/phosphodiesterase 4	0.4047	65
SPINK14	Serine peptidase inhibitor Kazal type 14 (putative)	0.4044	35

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	107.8 nTPM
Adipose tissue	141.1 nTPM
Breast	74.6 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	31.2 nTPM
Lung	31.2 nTPM

Astrocytes	82.6 nTPM
Brain	82.6 nTPM

B-cells	45.8 nTPM
Adipose tissue	148.9 nTPM
Liver	72.9 nTPM
Kidney	47.6 nTPM
Breast	37.5 nTPM
Stomach	35.9 nTPM
Lymph node	28.5 nTPM
Colon	25.5 nTPM
Spleen	25.0 nTPM
PBMC	18.6 nTPM
Bone marrow	18.0 nTPM

Dendritic cells	72.0 nTPM
Adipose tissue	156.3 nTPM
Breast	35.7 nTPM
PBMC	23.9 nTPM

Endothelial cells	80.3 nTPM
Liver	315.5 nTPM
Prostate	190.2 nTPM
Skeletal muscle	170.5 nTPM
Heart muscle	113.1 nTPM
Lung	53.0 nTPM
Breast	52.3 nTPM
Placenta	47.2 nTPM
Endometrium	40.5 nTPM
Esophagus	32.0 nTPM
Ovary	31.7 nTPM
Pancreas	23.1 nTPM
Eye	21.8 nTPM
Testis	16.9 nTPM
Skin	15.7 nTPM

Fibroblasts	28.1 nTPM
Heart muscle	87.7 nTPM
Prostate	51.2 nTPM
Stomach	34.1 nTPM
Esophagus	22.5 nTPM
Lung	22.4 nTPM
Placenta	21.8 nTPM
Ovary	15.9 nTPM
Skeletal muscle	15.7 nTPM
Breast	14.2 nTPM
Skin	13.2 nTPM
Adipose tissue	10.9 nTPM

Intestinal goblet cells	32.2 nTPM
Rectum	45.8 nTPM
Small intestine	29.4 nTPM
Colon	21.5 nTPM

Macrophages	53.2 nTPM
Spleen	100.6 nTPM
Adipose tissue	94.2 nTPM
Prostate	76.8 nTPM
Stomach	76.2 nTPM
Bone marrow	61.2 nTPM
Skeletal muscle	54.6 nTPM
Lung	53.0 nTPM
Endometrium	49.2 nTPM
Pancreas	46.0 nTPM
PBMC	40.9 nTPM
Kidney	37.8 nTPM
Esophagus	36.2 nTPM
Testis	25.5 nTPM
Ovary	23.5 nTPM
Breast	22.7 nTPM

Paneth cells	24.6 nTPM
Rectum	41.8 nTPM
Small intestine	18.8 nTPM
Colon	13.2 nTPM

Plasma cells	97.9 nTPM
Adipose tissue	123.8 nTPM
Esophagus	104.7 nTPM
Spleen	101.1 nTPM
Stomach	82.6 nTPM
Bone marrow	77.4 nTPM

Respiratory ciliated cells	48.7 nTPM
Bronchus	65.3 nTPM
Lung	32.1 nTPM

Smooth muscle cells	60.8 nTPM
Prostate	160.7 nTPM
Skeletal muscle	94.4 nTPM
Heart muscle	77.1 nTPM
Bronchus	71.0 nTPM
Skin	57.2 nTPM
Esophagus	54.3 nTPM
Adipose tissue	41.5 nTPM
Ovary	37.9 nTPM
Endometrium	35.6 nTPM
Breast	29.2 nTPM
Pancreas	10.3 nTPM

T-cells	30.5 nTPM
Liver	60.2 nTPM
Ovary	48.9 nTPM
Endometrium	41.9 nTPM
Skeletal muscle	40.1 nTPM
Adipose tissue	39.7 nTPM
Esophagus	32.8 nTPM
Lymph node	32.1 nTPM
Lung	31.9 nTPM
PBMC	26.2 nTPM
Spleen	25.4 nTPM
Stomach	25.1 nTPM
Prostate	23.6 nTPM
Bone marrow	22.7 nTPM
Kidney	22.0 nTPM
Colon	18.5 nTPM
Breast	14.2 nTPM
Skin	12.9 nTPM

Basal keratinocytes	9.3 nTPM
Skin	9.3 nTPM

Basal prostatic cells	30.6 nTPM
Prostate	30.6 nTPM

Basal respiratory cells	24.9 nTPM
Bronchus	24.9 nTPM

Basal squamous epithelial cells	16.5 nTPM
Esophagus	16.5 nTPM

Undifferentiated cells	29.3 nTPM
Rectum	38.9 nTPM
Colon	25.4 nTPM
Small intestine	23.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC