Single cell type - SUGP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SUGP2
Gene descriptionⁱ Full gene name according to HGNC.	SURP and G-patch domain containing 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SUGP2 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZNF714	Zinc finger protein 714	0.6132	52
CCDC144A	Coiled-coil domain containing 144A	0.5987	66
FBXO43	F-box protein 43	0.5677	66
ZNF431	Zinc finger protein 431	0.5440	52
SIMC1	SUMO interacting motifs containing 1	0.5391	52
MAP3K15	Mitogen-activated protein kinase kinase kinase 15	0.5337	52
SPG7	SPG7 matrix AAA peptidase subunit, paraplegin	0.5335	52
ANKRD62	Ankyrin repeat domain 62	0.5180	66
ATP8B3	ATPase phospholipid transporting 8B3	0.5076	66
DBF4B	DBF4 zinc finger B	0.5072	13
CDAN1	Codanin 1	0.5029	52
KANSL3	KAT8 regulatory NSL complex subunit 3	0.5011	40
GPATCH2L	G-patch domain containing 2 like	0.4980	52
AC240274.1	Neuroblastoma breakpoint family member 1	0.4976	13
SUPT20H	SPT20 homolog, SAGA complex component	0.4930	66

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	24.5 nTPM
Adipose tissue	29.2 nTPM
Breast	19.8 nTPM

Alveolar cells type 1	41.7 nTPM
Lung	41.7 nTPM

Alveolar cells type 2	45.1 nTPM
Lung	45.1 nTPM

Astrocytes	69.9 nTPM
Brain	69.9 nTPM

B-cells	22.9 nTPM
Adipose tissue	43.1 nTPM
Breast	34.7 nTPM
Colon	30.3 nTPM
PBMC	27.1 nTPM
Bone marrow	20.4 nTPM
Liver	19.5 nTPM
Lymph node	18.7 nTPM
Spleen	18.0 nTPM
Stomach	16.8 nTPM
Kidney	0.0 nTPM

Dendritic cells	57.0 nTPM
Adipose tissue	97.3 nTPM
PBMC	39.8 nTPM
Breast	33.9 nTPM

Endothelial cells	25.2 nTPM
Eye	43.7 nTPM
Ovary	35.6 nTPM
Heart muscle	29.5 nTPM
Endometrium	28.6 nTPM
Lung	28.1 nTPM
Skeletal muscle	27.7 nTPM
Liver	26.6 nTPM
Prostate	26.2 nTPM
Testis	25.8 nTPM
Placenta	19.9 nTPM
Breast	17.6 nTPM
Skin	17.4 nTPM
Esophagus	14.9 nTPM
Pancreas	11.6 nTPM

Fibroblasts	29.1 nTPM
Ovary	75.5 nTPM
Heart muscle	38.5 nTPM
Lung	38.0 nTPM
Skeletal muscle	29.1 nTPM
Placenta	27.8 nTPM
Adipose tissue	26.1 nTPM
Breast	23.1 nTPM
Prostate	21.1 nTPM
Esophagus	14.7 nTPM
Skin	14.2 nTPM
Stomach	11.9 nTPM

Intestinal goblet cells	22.5 nTPM
Rectum	27.9 nTPM
Small intestine	24.6 nTPM
Colon	15.0 nTPM

Macrophages	29.1 nTPM
Lung	56.3 nTPM
Adipose tissue	40.5 nTPM
Skeletal muscle	37.9 nTPM
Bone marrow	35.0 nTPM
Ovary	34.4 nTPM
Breast	32.7 nTPM
Testis	29.1 nTPM
Endometrium	28.0 nTPM
Spleen	27.9 nTPM
Kidney	27.2 nTPM
Esophagus	26.8 nTPM
Prostate	25.3 nTPM
Pancreas	15.3 nTPM
PBMC	13.6 nTPM
Stomach	5.9 nTPM

Paneth cells	23.2 nTPM
Rectum	26.9 nTPM
Small intestine	26.3 nTPM
Colon	16.5 nTPM

Plasma cells	36.1 nTPM
Adipose tissue	104.5 nTPM
Bone marrow	33.0 nTPM
Spleen	19.8 nTPM
Esophagus	12.3 nTPM
Stomach	10.8 nTPM

Respiratory ciliated cells	42.5 nTPM
Lung	45.2 nTPM
Bronchus	39.9 nTPM

Smooth muscle cells	22.8 nTPM
Ovary	49.0 nTPM
Endometrium	37.4 nTPM
Adipose tissue	28.8 nTPM
Skeletal muscle	25.8 nTPM
Breast	21.1 nTPM
Prostate	19.6 nTPM
Pancreas	18.2 nTPM
Heart muscle	16.4 nTPM
Skin	16.0 nTPM
Bronchus	9.4 nTPM
Esophagus	9.3 nTPM

T-cells	29.3 nTPM
Lung	63.8 nTPM
Adipose tissue	50.3 nTPM
Skeletal muscle	41.7 nTPM
Liver	41.3 nTPM
Ovary	35.6 nTPM
Endometrium	33.7 nTPM
PBMC	31.2 nTPM
Prostate	28.4 nTPM
Breast	26.6 nTPM
Colon	26.1 nTPM
Kidney	26.0 nTPM
Esophagus	19.7 nTPM
Bone marrow	19.6 nTPM
Skin	15.7 nTPM
Spleen	13.9 nTPM
Stomach	13.4 nTPM
Lymph node	12.0 nTPM

Basal prostatic cells	22.6 nTPM
Prostate	22.6 nTPM

Basal respiratory cells	17.9 nTPM
Bronchus	17.9 nTPM

Basal squamous epithelial cells	18.8 nTPM
Esophagus	18.8 nTPM

Collecting duct cells	27.6 nTPM
Kidney	27.6 nTPM

Undifferentiated cells	26.9 nTPM
Rectum	32.8 nTPM
Small intestine	26.5 nTPM
Colon	21.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC