Single cell type - NTHL1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NTHL1
Gene descriptionⁱ Full gene name according to HGNC.	Nth like DNA glycosylase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Hepatocytes - Metabolism (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Hepatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Hepatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NTHL1 is part of cluster 2 Hepatocytes - Metabolism with confidenceⁱ 1
205 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CCL16	C-C motif chemokine ligand 16	0.9242	2
AKR1C4	Aldo-keto reductase family 1 member C4	0.9193	2
MAT1A	Methionine adenosyltransferase 1A	0.9185	2
RTP3	Receptor transporter protein 3	0.9178	2
TAT	Tyrosine aminotransferase	0.9170	2
MBL2	Mannose binding lectin 2	0.9167	2
ANG	Angiogenin	0.9161	2
ALB	Albumin	0.9142	2
BAAT	Bile acid-CoA:amino acid N-acyltransferase	0.9138	2
UGT2B4	UDP glucuronosyltransferase family 2 member B4	0.9130	2
APOA5	Apolipoprotein A5	0.9129	2
CYP7A1	Cytochrome P450 family 7 subfamily A member 1	0.9117	2
APOH	Apolipoprotein H	0.9100	2
SLC17A2	Solute carrier family 17 member 2	0.9092	2
TTR	Transthyretin	0.9091	2

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	47.2 nTPM
Breast	61.9 nTPM
Adipose tissue	32.5 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	27.5 nTPM
Lung	27.5 nTPM

Astrocytes	2.9 nTPM
Brain	2.9 nTPM

B-cells	12.9 nTPM
Liver	47.4 nTPM
Breast	17.3 nTPM
PBMC	17.1 nTPM
Kidney	9.5 nTPM
Bone marrow	9.0 nTPM
Spleen	8.3 nTPM
Colon	6.4 nTPM
Adipose tissue	6.0 nTPM
Lymph node	4.4 nTPM
Stomach	3.7 nTPM

Dendritic cells	8.1 nTPM
Breast	14.9 nTPM
Adipose tissue	5.3 nTPM
PBMC	4.0 nTPM

Endothelial cells	36.5 nTPM
Placenta	62.0 nTPM
Liver	55.9 nTPM
Testis	51.9 nTPM
Ovary	50.0 nTPM
Lung	49.9 nTPM
Breast	47.8 nTPM
Skin	43.2 nTPM
Skeletal muscle	39.4 nTPM
Esophagus	26.3 nTPM
Endometrium	22.7 nTPM
Eye	20.3 nTPM
Pancreas	15.5 nTPM
Prostate	14.7 nTPM
Heart muscle	11.6 nTPM

Fibroblasts	17.6 nTPM
Ovary	47.8 nTPM
Breast	26.2 nTPM
Placenta	22.0 nTPM
Skin	16.9 nTPM
Esophagus	16.5 nTPM
Adipose tissue	13.9 nTPM
Heart muscle	13.5 nTPM
Skeletal muscle	11.8 nTPM
Lung	8.9 nTPM
Prostate	8.6 nTPM
Stomach	7.4 nTPM

Intestinal goblet cells	85.3 nTPM
Colon	158.7 nTPM
Rectum	59.0 nTPM
Small intestine	38.2 nTPM

Macrophages	9.3 nTPM
Kidney	14.3 nTPM
PBMC	13.6 nTPM
Testis	12.8 nTPM
Skeletal muscle	11.6 nTPM
Breast	11.1 nTPM
Prostate	10.3 nTPM
Pancreas	10.2 nTPM
Lung	9.8 nTPM
Esophagus	9.4 nTPM
Endometrium	8.9 nTPM
Ovary	8.7 nTPM
Spleen	8.3 nTPM
Adipose tissue	7.5 nTPM
Bone marrow	2.5 nTPM
Stomach	0.0 nTPM

Paneth cells	81.6 nTPM
Colon	181.2 nTPM
Rectum	44.9 nTPM
Small intestine	18.8 nTPM

Plasma cells	16.0 nTPM
Spleen	31.2 nTPM
Bone marrow	24.7 nTPM
Stomach	14.2 nTPM
Adipose tissue	9.7 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	23.5 nTPM
Bronchus	29.5 nTPM
Lung	17.5 nTPM

Smooth muscle cells	23.6 nTPM
Breast	41.6 nTPM
Skeletal muscle	29.2 nTPM
Skin	28.6 nTPM
Esophagus	26.4 nTPM
Heart muscle	24.3 nTPM
Prostate	20.6 nTPM
Endometrium	20.3 nTPM
Pancreas	20.1 nTPM
Adipose tissue	18.1 nTPM
Bronchus	15.2 nTPM
Ovary	14.8 nTPM

T-cells	12.2 nTPM
Ovary	37.8 nTPM
Liver	31.3 nTPM
Kidney	15.8 nTPM
Esophagus	13.1 nTPM
Colon	12.4 nTPM
PBMC	11.5 nTPM
Endometrium	10.5 nTPM
Skin	10.2 nTPM
Breast	9.9 nTPM
Prostate	9.5 nTPM
Bone marrow	8.5 nTPM
Spleen	7.7 nTPM
Lung	7.6 nTPM
Skeletal muscle	7.2 nTPM
Stomach	6.6 nTPM
Lymph node	4.6 nTPM
Adipose tissue	3.3 nTPM

Basal prostatic cells	16.4 nTPM
Prostate	16.4 nTPM

Basal respiratory cells	21.6 nTPM
Bronchus	21.6 nTPM

Basal squamous epithelial cells	8.0 nTPM
Esophagus	8.0 nTPM

Cholangiocytes	44.3 nTPM
Liver	44.3 nTPM

Undifferentiated cells	56.8 nTPM
Colon	75.6 nTPM
Rectum	56.3 nTPM
Small intestine	38.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC