Single cell type - TLE2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TLE2
Gene descriptionⁱ Full gene name according to HGNC.	TLE family member 2, transcriptional corepressor
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Bipolar cells - Visual perception (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (memory B-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (AN3-CA, RT4, T-47d)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TLE2 is part of cluster 56 Bipolar cells - Visual perception with confidenceⁱ 1
199 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PCP4L1	Purkinje cell protein 4 like 1	0.5491	56
SCUBE2	Signal peptide, CUB domain and EGF like domain containing 2	0.5087	35
SYNDIG1L	Synapse differentiation inducing 1 like	0.4968	56
PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B	0.4738	53
ADAMTS20	ADAM metallopeptidase with thrombospondin type 1 motif 20	0.4632	8
TMEM30B	Transmembrane protein 30B	0.4528	22
RAB3IP	RAB3A interacting protein	0.4458	25
NFIB	Nuclear factor I B	0.4454	8
RERE	Arginine-glutamic acid dipeptide repeats	0.4433	8
LURAP1L	Leucine rich adaptor protein 1 like	0.4409	35
AMIGO1	Adhesion molecule with Ig like domain 1	0.4407	56
HDX	Highly divergent homeobox	0.4392	8
EPHB2	EPH receptor B2	0.4392	53
TCEAL6	Transcription elongation factor A like 6	0.4387	56
KCNQ4	Potassium voltage-gated channel subfamily Q member 4	0.4375	8

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	27.1 nTPM
Breast	33.3 nTPM
Adipose tissue	21.0 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	17.6 nTPM
Lung	17.6 nTPM

Astrocytes	1.6 nTPM
Brain	1.6 nTPM

B-cells	0.7 nTPM
Colon	1.6 nTPM
PBMC	1.4 nTPM
Breast	1.3 nTPM
Adipose tissue	1.0 nTPM
Liver	0.9 nTPM
Lymph node	0.5 nTPM
Stomach	0.5 nTPM
Kidney	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Dendritic cells	2.8 nTPM
Breast	6.5 nTPM
Adipose tissue	1.8 nTPM
PBMC	0.0 nTPM

Endothelial cells	10.3 nTPM
Liver	30.2 nTPM
Breast	20.6 nTPM
Ovary	20.4 nTPM
Skeletal muscle	12.8 nTPM
Heart muscle	12.2 nTPM
Eye	7.3 nTPM
Endometrium	7.1 nTPM
Prostate	6.9 nTPM
Placenta	6.8 nTPM
Esophagus	6.2 nTPM
Pancreas	3.9 nTPM
Testis	3.8 nTPM
Skin	3.5 nTPM
Lung	3.1 nTPM

Fibroblasts	14.8 nTPM
Heart muscle	35.6 nTPM
Adipose tissue	26.9 nTPM
Breast	24.9 nTPM
Skeletal muscle	19.9 nTPM
Skin	13.9 nTPM
Ovary	11.1 nTPM
Prostate	9.5 nTPM
Stomach	7.4 nTPM
Lung	6.7 nTPM
Esophagus	3.5 nTPM
Placenta	3.4 nTPM

Intestinal goblet cells	14.9 nTPM
Rectum	17.7 nTPM
Colon	16.5 nTPM
Small intestine	10.7 nTPM

Macrophages	1.1 nTPM
Prostate	3.4 nTPM
Stomach	2.9 nTPM
Skeletal muscle	2.5 nTPM
Endometrium	2.0 nTPM
Testis	1.7 nTPM
Breast	1.5 nTPM
Lung	0.8 nTPM
Adipose tissue	0.7 nTPM
Ovary	0.6 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Paneth cells	9.8 nTPM
Rectum	15.7 nTPM
Colon	9.9 nTPM
Small intestine	3.7 nTPM

Plasma cells	0.3 nTPM
Adipose tissue	1.3 nTPM
Stomach	0.4 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	10.0 nTPM
Bronchus	14.2 nTPM
Lung	5.8 nTPM

Smooth muscle cells	11.2 nTPM
Heart muscle	26.9 nTPM
Prostate	17.2 nTPM
Skeletal muscle	17.1 nTPM
Adipose tissue	13.3 nTPM
Bronchus	11.3 nTPM
Breast	10.4 nTPM
Endometrium	9.5 nTPM
Skin	7.3 nTPM
Esophagus	6.2 nTPM
Ovary	2.1 nTPM
Pancreas	1.6 nTPM

T-cells	2.3 nTPM
Ovary	6.7 nTPM
Breast	4.4 nTPM
Adipose tissue	3.7 nTPM
PBMC	3.0 nTPM
Bone marrow	2.8 nTPM
Kidney	2.7 nTPM
Endometrium	2.4 nTPM
Skeletal muscle	2.3 nTPM
Lymph node	2.3 nTPM
Skin	1.9 nTPM
Spleen	1.9 nTPM
Lung	1.5 nTPM
Colon	1.4 nTPM
Liver	1.4 nTPM
Stomach	0.2 nTPM
Prostate	0.0 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	3.6 nTPM
Skin	3.6 nTPM

Basal prostatic cells	34.2 nTPM
Prostate	34.2 nTPM

Basal respiratory cells	8.3 nTPM
Bronchus	8.3 nTPM

Basal squamous epithelial cells	11.4 nTPM
Esophagus	11.4 nTPM

Undifferentiated cells	26.5 nTPM
Colon	30.4 nTPM
Rectum	26.5 nTPM
Small intestine	22.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC