Single cell type - ADGRF5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ADGRF5
Gene descriptionⁱ Full gene name according to HGNC.	Adhesion G protein-coupled receptor F5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	G-protein coupled receptors Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Adipocytes & Endothelial cells - Angiogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Alveolar cells type 2, Adipocytes, Alveolar cells type 1, Hepatic stellate cells, Endothelial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Group enriched (HUVEC TERT2, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Alveolar cells type 2, Adipocytes, Alveolar cells type 1, Hepatic stellate cells, Endothelial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ADGRF5 is part of cluster 14 Adipocytes & Endothelial cells - Angiogenesis with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FMO2	Flavin containing dimethylaniline monoxygenase 2	0.7705	14
VWF	Von Willebrand factor	0.7519	14
F8	Coagulation factor VIII	0.7509	14
BTNL9	Butyrophilin like 9	0.7446	14
MAP3K6	Mitogen-activated protein kinase kinase kinase 6	0.7372	14
AQP1	Aquaporin 1 (Colton blood group)	0.7237	14
EPAS1	Endothelial PAS domain protein 1	0.7092	14
USHBP1	USH1 protein network component harmonin binding protein 1	0.7014	14
TACC1	Transforming acidic coiled-coil containing protein 1	0.7010	14
CAV1	Caveolin 1	0.6977	14
DIPK2B	Divergent protein kinase domain 2B	0.6925	43
ARHGEF15	Rho guanine nucleotide exchange factor 15	0.6845	14
SHANK3	SH3 and multiple ankyrin repeat domains 3	0.6837	14
MMRN2	Multimerin 2	0.6814	14
C1QTNF9	C1q and TNF related 9	0.6792	14

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Astrocytes	2.0 nTPM
Brain	2.0 nTPM

B-cells	2.9 nTPM
Kidney	14.3 nTPM
Liver	7.1 nTPM
Breast	6.6 nTPM
Stomach	0.5 nTPM
Lymph node	0.1 nTPM
Colon	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Basal keratinocytes	0.0 nTPM
Skin	0.0 nTPM

Basal prostatic cells	0.2 nTPM
Prostate	0.2 nTPM

Basal respiratory cells	0.0 nTPM
Bronchus	0.0 nTPM

Adipocytes	428.1 nTPM
Adipose tissue	566.6 nTPM
Breast	289.5 nTPM

Dendritic cells	1.1 nTPM
Breast	3.3 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM

Endothelial cells	222.6 nTPM
Heart muscle	671.7 nTPM
Skeletal muscle	563.4 nTPM
Lung	324.4 nTPM
Ovary	308.3 nTPM
Eye	228.1 nTPM
Breast	183.8 nTPM
Testis	168.3 nTPM
Endometrium	147.2 nTPM
Pancreas	135.1 nTPM
Prostate	114.8 nTPM
Placenta	97.8 nTPM
Esophagus	91.5 nTPM
Liver	82.6 nTPM
Skin	0.0 nTPM

Fibroblasts	9.0 nTPM
Stomach	32.7 nTPM
Heart muscle	29.3 nTPM
Lung	21.2 nTPM
Skeletal muscle	7.8 nTPM
Esophagus	2.2 nTPM
Breast	2.2 nTPM
Ovary	1.2 nTPM
Prostate	0.9 nTPM
Adipose tissue	0.9 nTPM
Placenta	0.2 nTPM
Skin	0.0 nTPM

Intestinal goblet cells	0.5 nTPM
Small intestine	1.4 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	2.7 nTPM
Lung	18.3 nTPM
Skeletal muscle	8.1 nTPM
Testis	4.0 nTPM
Kidney	3.8 nTPM
Prostate	2.2 nTPM
Breast	2.2 nTPM
Esophagus	1.6 nTPM
Endometrium	0.4 nTPM
Adipose tissue	0.3 nTPM
Ovary	0.1 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	1.2 nTPM
Esophagus	6.1 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	48.1 nTPM
Lung	96.2 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	80.1 nTPM
Adipose tissue	248.8 nTPM
Skeletal muscle	186.1 nTPM
Heart muscle	158.8 nTPM
Esophagus	77.6 nTPM
Endometrium	64.5 nTPM
Breast	63.4 nTPM
Ovary	40.7 nTPM
Prostate	40.0 nTPM
Pancreas	1.7 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM

Cholangiocytes	8.6 nTPM
Liver	8.6 nTPM

Collecting duct cells	1.8 nTPM
Kidney	1.8 nTPM

Distal tubular cells	11.7 nTPM
Kidney	11.7 nTPM

Early spermatids	10.6 nTPM
Testis	10.6 nTPM

T-cells	1.8 nTPM
Lung	12.2 nTPM
Esophagus	6.6 nTPM
Liver	4.2 nTPM
Skeletal muscle	4.2 nTPM
Breast	2.3 nTPM
Endometrium	0.3 nTPM
Stomach	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Undifferentiated cells	0.1 nTPM
Small intestine	0.2 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC