Single cell type - CSNK2A2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CSNK2A2
Gene descriptionⁱ Full gene name according to HGNC.	Casein kinase 2 alpha 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CSNK2A2 is part of cluster 34 Spermatids - Unknown function with confidenceⁱ 1
366 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
AKIRIN1	Akirin 1	0.7330	34
BAG5	BAG cochaperone 5	0.7093	34
MKRN2	Makorin ring finger protein 2	0.7071	34
LSM12	LSM12 homolog	0.7069	34
WDR64	WD repeat domain 64	0.7068	34
TFAM	Transcription factor A, mitochondrial	0.6943	34
ZNF345	Zinc finger protein 345	0.6907	34
TTLL2	Tubulin tyrosine ligase like 2	0.6766	34
SIRPD	Signal regulatory protein delta	0.6753	34
TSKS	Testis specific serine kinase substrate	0.6719	34
MEX3B	Mex-3 RNA binding family member B	0.6657	40
C1orf100	Chromosome 1 open reading frame 100	0.6619	34
TRIM42	Tripartite motif containing 42	0.6590	34
PCDHGB1	Protocadherin gamma subfamily B, 1	0.6577	34
NT5C1B-RDH14	NT5C1B-RDH14 readthrough	0.6540	34

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	30.6 nTPM
Adipose tissue	32.8 nTPM
Breast	28.4 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	22.5 nTPM
Lung	22.5 nTPM

Astrocytes	19.2 nTPM
Brain	19.2 nTPM

B-cells	16.7 nTPM
Adipose tissue	38.6 nTPM
Breast	29.4 nTPM
PBMC	20.0 nTPM
Colon	19.2 nTPM
Kidney	19.0 nTPM
Liver	14.8 nTPM
Lymph node	8.7 nTPM
Spleen	7.9 nTPM
Bone marrow	5.7 nTPM
Stomach	3.7 nTPM

Dendritic cells	28.3 nTPM
Adipose tissue	42.0 nTPM
Breast	22.9 nTPM
PBMC	20.0 nTPM

Endothelial cells	25.8 nTPM
Ovary	55.8 nTPM
Endometrium	43.0 nTPM
Heart muscle	35.6 nTPM
Lung	28.1 nTPM
Skeletal muscle	27.8 nTPM
Prostate	27.3 nTPM
Skin	24.3 nTPM
Placenta	23.3 nTPM
Eye	21.0 nTPM
Liver	19.2 nTPM
Breast	18.1 nTPM
Testis	17.4 nTPM
Esophagus	11.8 nTPM
Pancreas	7.7 nTPM

Fibroblasts	17.7 nTPM
Adipose tissue	36.1 nTPM
Ovary	28.7 nTPM
Skeletal muscle	25.6 nTPM
Lung	20.1 nTPM
Breast	18.3 nTPM
Skin	17.9 nTPM
Heart muscle	14.7 nTPM
Placenta	13.4 nTPM
Prostate	11.0 nTPM
Esophagus	7.5 nTPM
Stomach	1.5 nTPM

Intestinal goblet cells	11.9 nTPM
Rectum	18.8 nTPM
Colon	9.3 nTPM
Small intestine	7.8 nTPM

Macrophages	23.1 nTPM
Ovary	54.4 nTPM
Adipose tissue	37.5 nTPM
Skeletal muscle	30.7 nTPM
Endometrium	29.8 nTPM
PBMC	27.3 nTPM
Spleen	27.0 nTPM
Breast	25.1 nTPM
Testis	23.2 nTPM
Prostate	20.7 nTPM
Lung	19.9 nTPM
Stomach	14.7 nTPM
Kidney	10.6 nTPM
Bone marrow	10.0 nTPM
Esophagus	7.9 nTPM
Pancreas	7.7 nTPM

Paneth cells	11.5 nTPM
Colon	16.5 nTPM
Rectum	14.4 nTPM
Small intestine	3.7 nTPM

Plasma cells	9.2 nTPM
Adipose tissue	27.7 nTPM
Spleen	10.7 nTPM
Bone marrow	5.0 nTPM
Stomach	2.6 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	13.4 nTPM
Lung	14.6 nTPM
Bronchus	12.1 nTPM

Smooth muscle cells	23.2 nTPM
Ovary	53.1 nTPM
Adipose tissue	35.8 nTPM
Endometrium	34.8 nTPM
Heart muscle	25.6 nTPM
Breast	25.0 nTPM
Skeletal muscle	18.5 nTPM
Skin	17.5 nTPM
Prostate	14.0 nTPM
Pancreas	12.4 nTPM
Bronchus	10.4 nTPM
Esophagus	7.8 nTPM

T-cells	20.3 nTPM
Adipose tissue	47.5 nTPM
Ovary	46.7 nTPM
Skeletal muscle	38.3 nTPM
Endometrium	35.8 nTPM
Breast	31.3 nTPM
PBMC	23.8 nTPM
Skin	19.8 nTPM
Esophagus	19.7 nTPM
Colon	17.6 nTPM
Liver	14.8 nTPM
Lymph node	10.3 nTPM
Prostate	9.5 nTPM
Spleen	8.4 nTPM
Bone marrow	6.7 nTPM
Stomach	6.5 nTPM
Kidney	6.2 nTPM
Lung	3.0 nTPM

Basal keratinocytes	29.6 nTPM
Skin	29.6 nTPM

Basal prostatic cells	10.9 nTPM
Prostate	10.9 nTPM

Basal respiratory cells	13.0 nTPM
Bronchus	13.0 nTPM

Basal squamous epithelial cells	8.6 nTPM
Esophagus	8.6 nTPM

Undifferentiated cells	17.5 nTPM
Rectum	21.0 nTPM
Small intestine	18.3 nTPM
Colon	13.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC