Single cell type - ALDH3A2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ALDH3A2
Gene descriptionⁱ Full gene name according to HGNC.	Aldehyde dehydrogenase 3 family member A2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	22

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Squamous epithelial cells - Keratinization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal squamous epithelial cells, Squamous epithelial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (OE19)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal squamous epithelial cells, Squamous epithelial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ALDH3A2 is part of cluster 61 Squamous epithelial cells - Keratinization with confidenceⁱ 1
176 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
KRT15	Keratin 15	0.6609	61
TNS4	Tensin 4	0.6414	61
SIM2	SIM bHLH transcription factor 2	0.6050	61
KRT32	Keratin 32	0.6049	61
SOX15	SRY-box transcription factor 15	0.6031	61
KRT5	Keratin 5	0.5845	61
MSGN1	Mesogenin 1	0.5792	61
EVPLL	Envoplakin like	0.5762	61
PAX9	Paired box 9	0.5687	61
THSD4	Thrombospondin type 1 domain containing 4	0.5676	61
DMRTA1	DMRT like family A1	0.5657	61
TP53AIP1	Tumor protein p53 regulated apoptosis inducing protein 1	0.5640	61
FAM83B	Family with sequence similarity 83 member B	0.5563	22
GRB7	Growth factor receptor bound protein 7	0.5540	61
TSLP	Thymic stromal lymphopoietin	0.5504	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	22.1 nTPM
Breast	23.2 nTPM
Adipose tissue	21.0 nTPM

Alveolar cells type 1	176.3 nTPM
Lung	176.3 nTPM

Alveolar cells type 2	86.5 nTPM
Lung	86.5 nTPM

Astrocytes	14.7 nTPM
Brain	14.7 nTPM

B-cells	13.3 nTPM
Liver	26.7 nTPM
Kidney	19.0 nTPM
Stomach	15.9 nTPM
PBMC	14.3 nTPM
Bone marrow	13.9 nTPM
Lymph node	11.6 nTPM
Spleen	10.7 nTPM
Breast	9.4 nTPM
Colon	6.4 nTPM
Adipose tissue	5.0 nTPM

Basal squamous epithelial cells	287.4 nTPM
Esophagus	287.4 nTPM

Dendritic cells	8.2 nTPM
Breast	12.4 nTPM
Adipose tissue	12.2 nTPM
PBMC	0.0 nTPM

Endothelial cells	19.5 nTPM
Lung	53.0 nTPM
Breast	22.3 nTPM
Heart muscle	21.6 nTPM
Prostate	18.7 nTPM
Eye	17.0 nTPM
Liver	16.5 nTPM
Placenta	16.5 nTPM
Skin	16.2 nTPM
Ovary	16.2 nTPM
Pancreas	15.5 nTPM
Endometrium	15.5 nTPM
Esophagus	15.3 nTPM
Skeletal muscle	14.8 nTPM
Testis	13.6 nTPM

Fibroblasts	39.9 nTPM
Skeletal muscle	77.0 nTPM
Prostate	52.9 nTPM
Esophagus	49.4 nTPM
Adipose tissue	45.9 nTPM
Lung	44.6 nTPM
Skin	38.6 nTPM
Breast	36.9 nTPM
Heart muscle	33.8 nTPM
Stomach	26.7 nTPM
Placenta	17.1 nTPM
Ovary	16.2 nTPM

Intestinal goblet cells	27.7 nTPM
Small intestine	32.1 nTPM
Rectum	29.0 nTPM
Colon	22.1 nTPM

Macrophages	23.5 nTPM
Lung	47.2 nTPM
Kidney	34.0 nTPM
Pancreas	33.2 nTPM
Prostate	29.8 nTPM
Ovary	27.7 nTPM
Spleen	23.9 nTPM
Testis	22.6 nTPM
Bone marrow	22.5 nTPM
Skeletal muscle	20.5 nTPM
Adipose tissue	18.1 nTPM
Breast	16.9 nTPM
Endometrium	16.1 nTPM
Esophagus	14.2 nTPM
PBMC	13.6 nTPM
Stomach	11.7 nTPM

Paneth cells	28.7 nTPM
Rectum	33.1 nTPM
Small intestine	30.0 nTPM
Colon	23.1 nTPM

Plasma cells	28.6 nTPM
Esophagus	36.9 nTPM
Spleen	34.7 nTPM
Bone marrow	29.7 nTPM
Stomach	28.0 nTPM
Adipose tissue	13.6 nTPM

Respiratory ciliated cells	59.2 nTPM
Lung	75.8 nTPM
Bronchus	42.5 nTPM

Smooth muscle cells	22.1 nTPM
Prostate	61.8 nTPM
Ovary	25.6 nTPM
Esophagus	24.8 nTPM
Heart muscle	20.7 nTPM
Breast	18.9 nTPM
Endometrium	18.0 nTPM
Skin	15.7 nTPM
Bronchus	15.3 nTPM
Skeletal muscle	15.1 nTPM
Adipose tissue	13.6 nTPM
Pancreas	13.4 nTPM

Cholangiocytes	105.8 nTPM
Liver	105.8 nTPM

Cone photoreceptor cells	12.5 nTPM
Eye	12.5 nTPM

Cytotrophoblasts	12.5 nTPM
Placenta	12.5 nTPM

Distal enterocytes	48.9 nTPM
Rectum	56.9 nTPM
Colon	40.9 nTPM

T-cells	13.2 nTPM
Lung	22.8 nTPM
Lymph node	19.0 nTPM
Liver	17.9 nTPM
Kidney	17.8 nTPM
Endometrium	16.4 nTPM
Colon	15.7 nTPM
Skin	13.8 nTPM
Spleen	12.4 nTPM
PBMC	12.3 nTPM
Skeletal muscle	11.6 nTPM
Bone marrow	11.3 nTPM
Breast	11.1 nTPM
Stomach	10.8 nTPM
Prostate	9.5 nTPM
Adipose tissue	8.5 nTPM
Ovary	6.7 nTPM
Esophagus	6.6 nTPM

Undifferentiated cells	46.0 nTPM
Small intestine	57.3 nTPM
Rectum	41.1 nTPM
Colon	39.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC