Single cell type - PTGS2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PTGS2
Gene descriptionⁱ Full gene name according to HGNC.	Prostaglandin-endoperoxide synthase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (granulocytes, Alveolar cells type 1, Langerhans cells, Fibroblasts, Macrophages, Urothelial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enriched (BJ hTERT+)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (granulocytes, Alveolar cells type 1, Langerhans cells, Fibroblasts, Macrophages, Urothelial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PTGS2 is part of cluster 41 Macrophages - Immune response with confidenceⁱ 1
307 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SOD2	Superoxide dismutase 2	0.7577	41
G0S2	G0/G1 switch 2	0.7575	41
NFKBIA	NFKB inhibitor alpha	0.7186	41
HSPA6	Heat shock protein family A (Hsp70) member 6	0.6457	22
NAMPT	Nicotinamide phosphoribosyltransferase	0.6407	41
RGS2	Regulator of G protein signaling 2	0.6406	60
AHR	Aryl hydrocarbon receptor	0.6397	41
MMP19	Matrix metallopeptidase 19	0.6353	41
ITGAX	Integrin subunit alpha X	0.6327	41
PIGA	Phosphatidylinositol glycan anchor biosynthesis class A	0.6315	41
THBS1	Thrombospondin 1	0.6210	41
PLAUR	Plasminogen activator, urokinase receptor	0.6158	41
IL1RL1	Interleukin 1 receptor like 1	0.6106	60
HSPA1A	Heat shock protein family A (Hsp70) member 1A	0.5895	22
SAT1	Spermidine/spermine N1-acetyltransferase 1	0.5871	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	5.2 nTPM
Adipose tissue	7.9 nTPM
Breast	2.5 nTPM

Alveolar cells type 2	77.7 nTPM
Lung	77.7 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	7.4 nTPM
Colon	57.5 nTPM
Breast	8.1 nTPM
Spleen	3.5 nTPM
Stomach	2.2 nTPM
Lymph node	1.5 nTPM
Adipose tissue	0.5 nTPM
Liver	0.4 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM

Basal keratinocytes	118.8 nTPM
Skin	118.8 nTPM

Dendritic cells	4.2 nTPM
Adipose tissue	10.5 nTPM
Breast	2.2 nTPM
PBMC	0.0 nTPM

Endothelial cells	31.1 nTPM
Prostate	118.7 nTPM
Skin	78.1 nTPM
Esophagus	60.0 nTPM
Eye	55.0 nTPM
Skeletal muscle	31.4 nTPM
Endometrium	25.9 nTPM
Pancreas	15.5 nTPM
Heart muscle	15.0 nTPM
Lung	12.5 nTPM
Testis	7.7 nTPM
Placenta	7.3 nTPM
Liver	4.6 nTPM
Breast	3.7 nTPM
Ovary	0.4 nTPM

Fibroblasts	270.7 nTPM
Prostate	2460.9 nTPM
Skin	132.9 nTPM
Esophagus	112.9 nTPM
Stomach	83.2 nTPM
Skeletal muscle	62.4 nTPM
Adipose tissue	38.7 nTPM
Lung	35.7 nTPM
Breast	23.8 nTPM
Heart muscle	19.3 nTPM
Ovary	5.3 nTPM
Placenta	2.7 nTPM

Intestinal goblet cells	1.0 nTPM
Small intestine	1.8 nTPM
Colon	0.7 nTPM
Rectum	0.5 nTPM

Macrophages	173.1 nTPM
Adipose tissue	592.7 nTPM
Spleen	544.4 nTPM
Stomach	272.5 nTPM
Esophagus	247.1 nTPM
Endometrium	203.3 nTPM
Skeletal muscle	192.0 nTPM
Breast	163.5 nTPM
Prostate	129.6 nTPM
Testis	116.8 nTPM
Lung	57.0 nTPM
Kidney	36.3 nTPM
Ovary	24.9 nTPM
Pancreas	12.8 nTPM
Bone marrow	3.7 nTPM
PBMC	0.0 nTPM

Paneth cells	0.1 nTPM
Rectum	0.4 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	2.0 nTPM
Adipose tissue	8.4 nTPM
Spleen	1.0 nTPM
Stomach	0.4 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	13.1 nTPM
Bronchus	17.5 nTPM
Lung	8.7 nTPM

Smooth muscle cells	12.8 nTPM
Prostate	48.7 nTPM
Skin	25.1 nTPM
Bronchus	21.6 nTPM
Heart muscle	10.6 nTPM
Pancreas	9.3 nTPM
Endometrium	5.3 nTPM
Esophagus	4.6 nTPM
Skeletal muscle	4.4 nTPM
Adipose tissue	4.3 nTPM
Breast	3.9 nTPM
Ovary	2.8 nTPM

T-cells	10.8 nTPM
Prostate	80.4 nTPM
Lung	42.6 nTPM
Endometrium	20.5 nTPM
Skin	17.5 nTPM
Esophagus	6.6 nTPM
Skeletal muscle	5.9 nTPM
Spleen	3.5 nTPM
Adipose tissue	2.3 nTPM
Colon	1.4 nTPM
Liver	1.1 nTPM
Breast	0.7 nTPM
Lymph node	0.2 nTPM
PBMC	0.1 nTPM
Stomach	0.1 nTPM
Kidney	0.0 nTPM
Ovary	0.0 nTPM
Bone marrow	0.0 nTPM

Endometrial stromal cells	9.9 nTPM
Endometrium	9.9 nTPM

Excitatory neurons	3.8 nTPM
Brain	3.8 nTPM

Undifferentiated cells	1.2 nTPM
Small intestine	1.6 nTPM
Colon	1.0 nTPM
Rectum	1.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC