Single cell type - ST6GAL1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ST6GAL1
Gene descriptionⁱ Full gene name according to HGNC.	ST6 beta-galactoside alpha-2,6-sialyltransferase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	17

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Hepatocytes - Hemostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hepatocytes, Microglial cells, Hepatic stellate cells, Collecting duct cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Daudi, U-266/70, U-266/84, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hepatocytes, Microglial cells, Hepatic stellate cells, Collecting duct cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ST6GAL1 is part of cluster 15 Hepatocytes - Hemostasis with confidenceⁱ 1
129 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SAA1	Serum amyloid A1	0.6678	15
SAA2	Serum amyloid A2	0.6671	15
HABP2	Hyaluronan binding protein 2	0.6264	15
LRG1	Leucine rich alpha-2-glycoprotein 1	0.6192	15
CYP3A7-CYP3A51P	CYP3A7-CYP3A51P readthrough	0.6171	15
CYP3A7	Cytochrome P450 family 3 subfamily A member 7	0.6170	15
SAA4	Serum amyloid A4, constitutive	0.6139	2
AMDHD1	Amidohydrolase domain containing 1	0.6136	15
ABCB4	ATP binding cassette subfamily B member 4	0.6128	2
ITIH2	Inter-alpha-trypsin inhibitor heavy chain 2	0.6114	15
CRP	C-reactive protein	0.6112	15
CYP2A7	Cytochrome P450 family 2 subfamily A member 7	0.6112	15
ITIH3	Inter-alpha-trypsin inhibitor heavy chain 3	0.6105	15
GC	GC vitamin D binding protein	0.6092	15
SERPINA10	Serpin family A member 10	0.6084	15

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	34.6 nTPM
Adipose tissue	38.2 nTPM
Breast	30.9 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	27.4 nTPM
Lung	27.4 nTPM

Astrocytes	13.4 nTPM
Brain	13.4 nTPM

B-cells	110.0 nTPM
Colon	164.5 nTPM
Lymph node	149.3 nTPM
Liver	145.1 nTPM
Stomach	130.3 nTPM
Bone marrow	121.0 nTPM
Spleen	118.7 nTPM
Adipose tissue	113.8 nTPM
PBMC	82.8 nTPM
Breast	60.2 nTPM
Kidney	14.3 nTPM

Dendritic cells	26.3 nTPM
Breast	35.0 nTPM
PBMC	31.8 nTPM
Adipose tissue	12.1 nTPM

Endothelial cells	56.0 nTPM
Liver	310.9 nTPM
Testis	70.3 nTPM
Heart muscle	62.2 nTPM
Eye	61.5 nTPM
Esophagus	44.9 nTPM
Skeletal muscle	40.7 nTPM
Prostate	32.8 nTPM
Endometrium	32.3 nTPM
Skin	31.2 nTPM
Breast	31.2 nTPM
Lung	24.9 nTPM
Pancreas	15.5 nTPM
Placenta	13.7 nTPM
Ovary	12.3 nTPM

Enteroendocrine cells	94.1 nTPM
Rectum	145.6 nTPM
Colon	42.6 nTPM

Fibroblasts	3.7 nTPM
Heart muscle	13.1 nTPM
Lung	10.1 nTPM
Stomach	4.4 nTPM
Prostate	3.1 nTPM
Placenta	2.8 nTPM
Esophagus	1.9 nTPM
Breast	1.8 nTPM
Skin	1.5 nTPM
Skeletal muscle	1.3 nTPM
Ovary	0.6 nTPM
Adipose tissue	0.4 nTPM

Intestinal goblet cells	10.9 nTPM
Rectum	27.8 nTPM
Colon	2.9 nTPM
Small intestine	2.2 nTPM

Macrophages	18.2 nTPM
Breast	38.7 nTPM
Esophagus	31.5 nTPM
Testis	26.1 nTPM
Spleen	24.9 nTPM
Ovary	23.2 nTPM
Prostate	22.9 nTPM
Bone marrow	18.8 nTPM
Skeletal muscle	18.2 nTPM
Adipose tissue	17.1 nTPM
Endometrium	16.4 nTPM
Stomach	11.7 nTPM
Kidney	10.6 nTPM
Lung	7.8 nTPM
Pancreas	5.1 nTPM
PBMC	0.0 nTPM

Paneth cells	17.8 nTPM
Rectum	46.7 nTPM
Colon	6.5 nTPM
Small intestine	0.0 nTPM

Plasma cells	124.3 nTPM
Spleen	162.2 nTPM
Stomach	160.9 nTPM
Bone marrow	140.1 nTPM
Esophagus	92.4 nTPM
Adipose tissue	65.8 nTPM

Respiratory ciliated cells	39.8 nTPM
Bronchus	53.3 nTPM
Lung	26.2 nTPM

Smooth muscle cells	6.8 nTPM
Heart muscle	19.8 nTPM
Bronchus	14.1 nTPM
Esophagus	9.3 nTPM
Prostate	7.8 nTPM
Ovary	6.8 nTPM
Skin	4.5 nTPM
Endometrium	4.4 nTPM
Breast	4.1 nTPM
Skeletal muscle	2.1 nTPM
Pancreas	1.2 nTPM
Adipose tissue	0.4 nTPM

Basal keratinocytes	4.0 nTPM
Skin	4.0 nTPM

Basal prostatic cells	13.8 nTPM
Prostate	13.8 nTPM

Basal respiratory cells	68.0 nTPM
Bronchus	68.0 nTPM

Basal squamous epithelial cells	4.6 nTPM
Esophagus	4.6 nTPM

T-cells	28.4 nTPM
PBMC	58.5 nTPM
Lymph node	43.0 nTPM
Liver	42.2 nTPM
Skeletal muscle	39.3 nTPM
Lung	38.0 nTPM
Esophagus	32.8 nTPM
Bone marrow	32.1 nTPM
Spleen	29.6 nTPM
Ovary	28.9 nTPM
Breast	26.8 nTPM
Kidney	24.7 nTPM
Skin	18.8 nTPM
Adipose tissue	16.9 nTPM
Prostate	14.2 nTPM
Endometrium	14.2 nTPM
Stomach	11.8 nTPM
Colon	11.4 nTPM

Undifferentiated cells	37.3 nTPM
Rectum	75.1 nTPM
Colon	28.2 nTPM
Small intestine	8.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC