Single cell type - CLASP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CLASP1
Gene descriptionⁱ Full gene name according to HGNC.	Cytoplasmic linker associated protein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Excitatory neurons, Oligodendrocyte precursor cells, Inhibitory neurons, Astrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (NK-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Excitatory neurons, Oligodendrocyte precursor cells, Inhibitory neurons, Astrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CLASP1 is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 0.58
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NCAM2	Neural cell adhesion molecule 2	0.6896	42
BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase	0.6814	68
CADM2	Cell adhesion molecule 2	0.6523	42
ADGRL3	Adhesion G protein-coupled receptor L3	0.6521	68
NCAM1	Neural cell adhesion molecule 1	0.6321	42
LINGO1	Leucine rich repeat and Ig domain containing 1	0.6299	64
UBR3	Ubiquitin protein ligase E3 component n-recognin 3	0.6161	42
DLG2	Discs large MAGUK scaffold protein 2	0.6040	42
METTL25	Methyltransferase like 25	0.6015	42
NALCN	Sodium leak channel, non-selective	0.5937	42
TSTD3	Thiosulfate sulfurtransferase like domain containing 3	0.5930	8
PHACTR3	Phosphatase and actin regulator 3	0.5874	68
TMEM135	Transmembrane protein 135	0.5823	42
PHF21A	PHD finger protein 21A	0.5818	68
TSNARE1	T-SNARE domain containing 1	0.5707	21

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	21.8 nTPM
Adipose tissue	22.7 nTPM
Breast	20.9 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	12.8 nTPM
Lung	12.8 nTPM

B-cells	12.1 nTPM
PBMC	22.8 nTPM
Stomach	17.7 nTPM
Bone marrow	15.5 nTPM
Lymph node	15.2 nTPM
Spleen	11.8 nTPM
Adipose tissue	11.5 nTPM
Liver	11.4 nTPM
Breast	10.7 nTPM
Colon	4.8 nTPM
Kidney	0.0 nTPM

Basal keratinocytes	10.7 nTPM
Skin	10.7 nTPM

Dendritic cells	27.1 nTPM
Adipose tissue	40.7 nTPM
Breast	20.7 nTPM
PBMC	20.0 nTPM

Endothelial cells	17.5 nTPM
Liver	33.0 nTPM
Testis	32.9 nTPM
Ovary	25.8 nTPM
Skeletal muscle	24.8 nTPM
Endometrium	19.4 nTPM
Placenta	18.8 nTPM
Breast	18.2 nTPM
Heart muscle	15.5 nTPM
Skin	14.8 nTPM
Prostate	13.2 nTPM
Esophagus	11.3 nTPM
Eye	9.7 nTPM
Pancreas	3.9 nTPM
Lung	3.1 nTPM

Fibroblasts	13.8 nTPM
Heart muscle	28.3 nTPM
Skeletal muscle	22.4 nTPM
Adipose tissue	16.3 nTPM
Ovary	15.4 nTPM
Breast	12.9 nTPM
Esophagus	11.6 nTPM
Skin	11.5 nTPM
Stomach	10.4 nTPM
Placenta	8.5 nTPM
Prostate	7.6 nTPM
Lung	6.7 nTPM

Intestinal goblet cells	6.2 nTPM
Rectum	8.7 nTPM
Small intestine	7.1 nTPM
Colon	2.9 nTPM

Macrophages	12.0 nTPM
Testis	22.1 nTPM
Ovary	21.3 nTPM
Bone marrow	20.0 nTPM
Skeletal muscle	18.1 nTPM
Adipose tissue	16.5 nTPM
Esophagus	15.8 nTPM
Spleen	15.6 nTPM
Breast	13.8 nTPM
Endometrium	12.7 nTPM
Kidney	9.1 nTPM
Prostate	8.1 nTPM
Lung	7.7 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	7.4 nTPM
Rectum	8.2 nTPM
Small intestine	7.5 nTPM
Colon	6.5 nTPM

Plasma cells	21.9 nTPM
Adipose tissue	39.4 nTPM
Bone marrow	24.7 nTPM
Stomach	17.2 nTPM
Spleen	15.7 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	17.6 nTPM
Bronchus	26.5 nTPM
Lung	8.7 nTPM

Smooth muscle cells	15.2 nTPM
Heart muscle	24.7 nTPM
Bronchus	23.6 nTPM
Adipose tissue	17.4 nTPM
Endometrium	16.6 nTPM
Skeletal muscle	16.4 nTPM
Breast	14.6 nTPM
Skin	13.2 nTPM
Ovary	13.1 nTPM
Esophagus	12.4 nTPM
Prostate	9.4 nTPM
Pancreas	6.2 nTPM

T-cells	17.6 nTPM
Liver	38.2 nTPM
PBMC	31.3 nTPM
Stomach	28.5 nTPM
Skeletal muscle	27.8 nTPM
Endometrium	23.0 nTPM
Ovary	22.3 nTPM
Adipose tissue	19.0 nTPM
Bone marrow	18.7 nTPM
Breast	18.6 nTPM
Spleen	14.6 nTPM
Lymph node	12.8 nTPM
Skin	12.4 nTPM
Kidney	10.2 nTPM
Lung	9.1 nTPM
Colon	7.6 nTPM
Prostate	4.7 nTPM
Esophagus	0.0 nTPM

Astrocytes	197.9 nTPM
Brain	197.9 nTPM

Cone photoreceptor cells	45.9 nTPM
Eye	45.9 nTPM

Cytotrophoblasts	6.6 nTPM
Placenta	6.6 nTPM

Distal tubular cells	5.9 nTPM
Kidney	5.9 nTPM

Undifferentiated cells	6.6 nTPM
Rectum	9.7 nTPM
Small intestine	7.2 nTPM
Colon	2.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC