Single cell type - ARHGEF10L - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ARHGEF10L
Gene descriptionⁱ Full gene name according to HGNC.	Rho guanine nucleotide exchange factor 10 like
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Astrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (classical monocyte, intermediate monocyte, myeloid DC, non-classical monocyte)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Hep G2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Astrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ARHGEF10L is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ENGASE	Endo-beta-N-acetylglucosaminidase	0.5849	53
MAMDC4	MAM domain containing 4	0.5755	53
MNX1	Motor neuron and pancreas homeobox 1	0.5377	53
TPCN1	Two pore segment channel 1	0.5368	64
AIFM3	Apoptosis inducing factor mitochondria associated 3	0.5312	53
SH2B1	SH2B adaptor protein 1	0.5084	53
CLUH	Clustered mitochondria homolog	0.5063	53
NOX1	NADPH oxidase 1	0.4906	53
GPX2	Glutathione peroxidase 2	0.4903	53
KCNQ1	Potassium voltage-gated channel subfamily Q member 1	0.4826	53
SLC28A2	Solute carrier family 28 member 2	0.4749	53
NXPE4	Neurexophilin and PC-esterase domain family member 4	0.4735	53
NXPE2	Neurexophilin and PC-esterase domain family member 2	0.4712	27
MUC5B	Mucin 5B, oligomeric mucus/gel-forming	0.4619	53
ERN2	Endoplasmic reticulum to nucleus signaling 2	0.4573	27

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	1.3 nTPM
Breast	1.6 nTPM
Adipose tissue	1.1 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	7.4 nTPM
Lung	7.4 nTPM

B-cells	1.0 nTPM
Breast	5.3 nTPM
Stomach	1.8 nTPM
Colon	1.6 nTPM
Lymph node	1.0 nTPM
Liver	0.4 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Basal keratinocytes	5.7 nTPM
Skin	5.7 nTPM

Dendritic cells	0.1 nTPM
Adipose tissue	0.2 nTPM
PBMC	0.0 nTPM
Breast	0.0 nTPM

Endothelial cells	2.1 nTPM
Heart muscle	6.8 nTPM
Eye	5.7 nTPM
Skin	4.0 nTPM
Breast	3.4 nTPM
Placenta	2.9 nTPM
Endometrium	1.5 nTPM
Prostate	1.1 nTPM
Esophagus	1.0 nTPM
Liver	0.9 nTPM
Skeletal muscle	0.6 nTPM
Ovary	0.6 nTPM
Testis	0.3 nTPM
Lung	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	8.5 nTPM
Stomach	14.9 nTPM
Skin	14.6 nTPM
Skeletal muscle	14.0 nTPM
Adipose tissue	14.0 nTPM
Heart muscle	12.2 nTPM
Breast	7.7 nTPM
Placenta	5.7 nTPM
Esophagus	5.1 nTPM
Prostate	2.9 nTPM
Ovary	2.9 nTPM
Lung	0.0 nTPM

Intestinal goblet cells	45.5 nTPM
Small intestine	52.1 nTPM
Rectum	46.5 nTPM
Colon	37.8 nTPM

Macrophages	18.6 nTPM
Ovary	41.5 nTPM
Lung	41.0 nTPM
Adipose tissue	32.2 nTPM
Esophagus	22.0 nTPM
Testis	18.6 nTPM
Skeletal muscle	18.2 nTPM
Bone marrow	16.3 nTPM
Breast	14.8 nTPM
Endometrium	14.7 nTPM
Stomach	14.7 nTPM
Kidney	14.3 nTPM
Pancreas	12.8 nTPM
Spleen	10.4 nTPM
Prostate	6.9 nTPM
PBMC	0.0 nTPM

Paneth cells	24.9 nTPM
Rectum	35.8 nTPM
Small intestine	22.5 nTPM
Colon	16.5 nTPM

Plasma cells	0.2 nTPM
Adipose tissue	0.6 nTPM
Stomach	0.5 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	9.4 nTPM
Bronchus	17.3 nTPM
Lung	1.5 nTPM

Smooth muscle cells	18.3 nTPM
Heart muscle	53.0 nTPM
Skin	25.8 nTPM
Breast	25.7 nTPM
Esophagus	21.7 nTPM
Endometrium	16.1 nTPM
Adipose tissue	14.1 nTPM
Prostate	12.9 nTPM
Skeletal muscle	11.6 nTPM
Bronchus	8.4 nTPM
Ovary	7.4 nTPM
Pancreas	4.5 nTPM

T-cells	0.6 nTPM
Skin	3.3 nTPM
Colon	1.4 nTPM
Kidney	1.4 nTPM
Endometrium	1.1 nTPM
Breast	0.8 nTPM
PBMC	0.5 nTPM
Skeletal muscle	0.5 nTPM
Stomach	0.5 nTPM
Liver	0.2 nTPM
Adipose tissue	0.1 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Astrocytes	82.6 nTPM
Brain	82.6 nTPM

Cholangiocytes	20.0 nTPM
Liver	20.0 nTPM

Collecting duct cells	31.3 nTPM
Kidney	31.3 nTPM

Cytotrophoblasts	0.7 nTPM
Placenta	0.7 nTPM

Undifferentiated cells	46.1 nTPM
Rectum	53.1 nTPM
Colon	49.5 nTPM
Small intestine	35.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC