Single cell type - EIF4G3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EIF4G3
Gene descriptionⁱ Full gene name according to HGNC.	Eukaryotic translation initiation factor 4 gamma 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Excitatory neurons, Oligodendrocytes, Inhibitory neurons, Oligodendrocyte precursor cells, Microglial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Excitatory neurons, Oligodendrocytes, Inhibitory neurons, Oligodendrocyte precursor cells, Microglial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

EIF4G3 is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MBD5	Methyl-CpG binding domain protein 5	0.6739	42
TAS2R10	Taste 2 receptor member 10	0.6601	8
AMBRA1	Autophagy and beclin 1 regulator 1	0.6489	42
GRID1	Glutamate ionotropic receptor delta type subunit 1	0.6409	42
SCFD2	Sec1 family domain containing 2	0.6352	42
DOCK3	Dedicator of cytokinesis 3	0.6110	8
SAMD12	Sterile alpha motif domain containing 12	0.6066	42
UNC79	Unc-79 homolog, NALCN channel complex subunit	0.5988	21
ATXN1	Ataxin 1	0.5984	21
UNC5C	Unc-5 netrin receptor C	0.5967	42
TBC1D5	TBC1 domain family member 5	0.5959	42
MYO5A	Myosin VA	0.5943	42
REPS2	RALBP1 associated Eps domain containing 2	0.5923	42
PKP4	Plakophilin 4	0.5920	42
SPDYE11	Speedy/RINGO cell cycle regulator family member E11	0.5841	42

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	50.9 nTPM
Adipose tissue	60.0 nTPM
Breast	41.7 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	30.5 nTPM
Lung	30.5 nTPM

Astrocytes	181.5 nTPM
Brain	181.5 nTPM

B-cells	29.5 nTPM
Adipose tissue	39.6 nTPM
Spleen	38.0 nTPM
Stomach	34.5 nTPM
Lymph node	34.4 nTPM
Liver	29.4 nTPM
Bone marrow	27.0 nTPM
Breast	25.5 nTPM
Kidney	23.8 nTPM
Colon	22.3 nTPM
PBMC	20.0 nTPM

Dendritic cells	51.1 nTPM
PBMC	63.8 nTPM
Adipose tissue	57.1 nTPM
Breast	32.4 nTPM

Endothelial cells	42.7 nTPM
Lung	81.1 nTPM
Endometrium	74.8 nTPM
Ovary	64.4 nTPM
Prostate	50.2 nTPM
Eye	42.9 nTPM
Placenta	37.5 nTPM
Skeletal muscle	36.8 nTPM
Liver	35.7 nTPM
Testis	33.7 nTPM
Esophagus	32.6 nTPM
Breast	31.7 nTPM
Heart muscle	31.5 nTPM
Pancreas	23.1 nTPM
Skin	21.7 nTPM

Fibroblasts	33.8 nTPM
Lung	54.7 nTPM
Ovary	53.3 nTPM
Adipose tissue	45.0 nTPM
Heart muscle	41.5 nTPM
Prostate	38.8 nTPM
Skeletal muscle	37.1 nTPM
Esophagus	26.6 nTPM
Breast	25.0 nTPM
Placenta	19.8 nTPM
Skin	18.5 nTPM
Stomach	11.9 nTPM

Intestinal goblet cells	21.6 nTPM
Rectum	24.7 nTPM
Colon	22.1 nTPM
Small intestine	18.2 nTPM

Macrophages	39.3 nTPM
PBMC	81.8 nTPM
Endometrium	54.0 nTPM
Lung	50.6 nTPM
Adipose tissue	47.8 nTPM
Skeletal muscle	44.4 nTPM
Prostate	42.3 nTPM
Esophagus	39.3 nTPM
Ovary	36.5 nTPM
Bone marrow	36.3 nTPM
Spleen	33.2 nTPM
Breast	28.9 nTPM
Testis	27.4 nTPM
Stomach	26.4 nTPM
Pancreas	25.5 nTPM
Kidney	14.3 nTPM

Paneth cells	32.1 nTPM
Rectum	40.9 nTPM
Colon	32.9 nTPM
Small intestine	22.5 nTPM

Plasma cells	27.3 nTPM
Adipose tissue	39.4 nTPM
Spleen	29.9 nTPM
Bone marrow	26.4 nTPM
Esophagus	24.6 nTPM
Stomach	16.0 nTPM

Respiratory ciliated cells	51.1 nTPM
Lung	64.1 nTPM
Bronchus	38.0 nTPM

Smooth muscle cells	31.3 nTPM
Endometrium	55.1 nTPM
Adipose tissue	55.0 nTPM
Heart muscle	48.9 nTPM
Ovary	48.0 nTPM
Prostate	26.3 nTPM
Skeletal muscle	26.2 nTPM
Breast	26.0 nTPM
Pancreas	21.2 nTPM
Esophagus	20.1 nTPM
Skin	14.3 nTPM
Bronchus	2.9 nTPM

T-cells	23.7 nTPM
Endometrium	50.7 nTPM
Skeletal muscle	41.3 nTPM
Adipose tissue	32.8 nTPM
Stomach	32.1 nTPM
Lung	31.9 nTPM
Bone marrow	25.1 nTPM
Breast	24.8 nTPM
Colon	24.7 nTPM
Ovary	24.5 nTPM
Kidney	22.6 nTPM
Spleen	20.7 nTPM
Liver	18.6 nTPM
Lymph node	15.7 nTPM
Prostate	14.2 nTPM
PBMC	9.6 nTPM
Esophagus	6.6 nTPM
Skin	6.4 nTPM

Basal keratinocytes	20.6 nTPM
Skin	20.6 nTPM

Basal prostatic cells	19.9 nTPM
Prostate	19.9 nTPM

Basal respiratory cells	15.0 nTPM
Bronchus	15.0 nTPM

Basal squamous epithelial cells	17.1 nTPM
Esophagus	17.1 nTPM

Undifferentiated cells	29.6 nTPM
Colon	33.5 nTPM
Rectum	31.5 nTPM
Small intestine	23.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC