Single cell type - RASAL2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RASAL2
Gene descriptionⁱ Full gene name according to HGNC.	RAS protein activator like 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Neurons & Oligodendrocytes - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Excitatory neurons, Inhibitory neurons, Microglial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (hTERT-HME1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Excitatory neurons, Inhibitory neurons, Microglial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RASAL2 is part of cluster 21 Neurons & Oligodendrocytes - Neuronal signaling with confidenceⁱ 1
589 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FMN1	Formin 1	0.7827	8
HACE1	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	0.7764	21
DLGAP2	DLG associated protein 2	0.7463	21
SCN8A	Sodium voltage-gated channel alpha subunit 8	0.7221	21
RBFOX1	RNA binding fox-1 homolog 1	0.7100	21
HCN1	Hyperpolarization activated cyclic nucleotide gated potassium channel 1	0.7099	8
KLHL29	Kelch like family member 29	0.7056	8
AGBL4	ATP/GTP binding protein like 4	0.7024	21
CDKL5	Cyclin dependent kinase like 5	0.6999	21
ARL15	ADP ribosylation factor like GTPase 15	0.6914	21
ANKRD34C	Ankyrin repeat domain 34C	0.6867	21
RAPGEF4	Rap guanine nucleotide exchange factor 4	0.6839	8
EPHX4	Epoxide hydrolase 4	0.6831	21
TRPC5	Transient receptor potential cation channel subfamily C member 5	0.6755	21
STRC	Stereocilin	0.6669	21

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	99.8 nTPM
Adipose tissue	120.1 nTPM
Breast	79.5 nTPM

Alveolar cells type 1	76.9 nTPM
Lung	76.9 nTPM

Alveolar cells type 2	12.9 nTPM
Lung	12.9 nTPM

Astrocytes	47.3 nTPM
Brain	47.3 nTPM

B-cells	1.0 nTPM
Colon	3.2 nTPM
Adipose tissue	1.5 nTPM
Spleen	1.4 nTPM
Stomach	1.4 nTPM
Liver	1.3 nTPM
Bone marrow	0.8 nTPM
Lymph node	0.2 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Breast	0.0 nTPM

Dendritic cells	1.0 nTPM
Breast	2.5 nTPM
Adipose tissue	0.5 nTPM
PBMC	0.0 nTPM

Endothelial cells	66.2 nTPM
Skeletal muscle	119.5 nTPM
Ovary	111.9 nTPM
Endometrium	100.7 nTPM
Testis	84.5 nTPM
Heart muscle	69.3 nTPM
Esophagus	65.7 nTPM
Eye	63.1 nTPM
Breast	61.7 nTPM
Prostate	60.7 nTPM
Liver	52.2 nTPM
Placenta	44.4 nTPM
Skin	36.0 nTPM
Lung	34.3 nTPM
Pancreas	23.1 nTPM

Fibroblasts	18.4 nTPM
Lung	40.2 nTPM
Heart muscle	33.1 nTPM
Placenta	21.6 nTPM
Stomach	19.3 nTPM
Skeletal muscle	17.5 nTPM
Prostate	16.7 nTPM
Adipose tissue	14.7 nTPM
Breast	14.1 nTPM
Skin	9.7 nTPM
Ovary	9.7 nTPM
Esophagus	5.2 nTPM

Intestinal goblet cells	15.7 nTPM
Rectum	19.3 nTPM
Small intestine	14.4 nTPM
Colon	13.6 nTPM

Macrophages	16.5 nTPM
Lung	54.0 nTPM
Breast	33.9 nTPM
Pancreas	30.7 nTPM
Ovary	24.8 nTPM
Esophagus	23.6 nTPM
Skeletal muscle	17.6 nTPM
Adipose tissue	16.9 nTPM
Endometrium	12.7 nTPM
Prostate	10.3 nTPM
Testis	6.9 nTPM
Kidney	5.3 nTPM
Spleen	4.2 nTPM
Bone marrow	3.7 nTPM
Stomach	2.9 nTPM
PBMC	0.0 nTPM

Paneth cells	5.2 nTPM
Rectum	12.4 nTPM
Colon	3.3 nTPM
Small intestine	0.0 nTPM

Plasma cells	2.9 nTPM
Esophagus	12.3 nTPM
Adipose tissue	1.9 nTPM
Stomach	0.4 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	34.7 nTPM
Lung	40.8 nTPM
Bronchus	28.5 nTPM

Smooth muscle cells	56.9 nTPM
Skeletal muscle	125.4 nTPM
Adipose tissue	113.2 nTPM
Heart muscle	79.4 nTPM
Esophagus	58.9 nTPM
Endometrium	53.3 nTPM
Breast	53.0 nTPM
Ovary	45.5 nTPM
Prostate	31.9 nTPM
Skin	23.0 nTPM
Pancreas	21.8 nTPM
Bronchus	20.8 nTPM

T-cells	2.3 nTPM
Esophagus	19.7 nTPM
Endometrium	4.9 nTPM
Skeletal muscle	3.5 nTPM
Lung	3.0 nTPM
Breast	2.2 nTPM
Liver	1.4 nTPM
Skin	1.4 nTPM
Colon	1.0 nTPM
PBMC	0.9 nTPM
Kidney	0.7 nTPM
Adipose tissue	0.4 nTPM
Stomach	0.1 nTPM
Prostate	0.0 nTPM
Ovary	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Basal keratinocytes	15.9 nTPM
Skin	15.9 nTPM

Basal prostatic cells	10.0 nTPM
Prostate	10.0 nTPM

Basal squamous epithelial cells	8.0 nTPM
Esophagus	8.0 nTPM

Cholangiocytes	17.2 nTPM
Liver	17.2 nTPM

Undifferentiated cells	12.6 nTPM
Small intestine	15.3 nTPM
Rectum	13.6 nTPM
Colon	9.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC