Single cell type - BCAP29 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BCAP29
Gene descriptionⁱ Full gene name according to HGNC.	B cell receptor associated protein 29
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Early spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

BCAP29 is part of cluster 29 Early spermatids - Spermatogenesis with confidenceⁱ 1
337 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CALCOCO2	Calcium binding and coiled-coil domain 2	0.4587	29
LTN1	Listerin E3 ubiquitin protein ligase 1	0.4555	29
G2E3	G2/M-phase specific E3 ubiquitin protein ligase	0.4519	29
AOC2	Amine oxidase copper containing 2	0.4514	29
SEC22A	SEC22 homolog A, vesicle trafficking protein	0.4417	66
ZWILCH	Zwilch kinetochore protein	0.4380	66
SPDYE3	Speedy/RINGO cell cycle regulator family member E3	0.4351	29
TSPEAR	Thrombospondin type laminin G domain and EAR repeats	0.4303	29
HDAC7	Histone deacetylase 7	0.4216	14
EOGT	EGF domain specific O-linked N-acetylglucosamine transferase	0.4190	8
HSFY2	Heat shock transcription factor Y-linked 2	0.4174	29
C12orf29	Chromosome 12 open reading frame 29	0.4172	39
CX3CL1	C-X3-C motif chemokine ligand 1	0.4155	26
MAP4K3	Mitogen-activated protein kinase kinase kinase kinase 3	0.4113	44
CWC27	CWC27 spliceosome associated cyclophilin	0.4105	29

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	169.8 nTPM
Breast	185.4 nTPM
Adipose tissue	154.1 nTPM

Alveolar cells type 1	67.3 nTPM
Lung	67.3 nTPM

Alveolar cells type 2	57.2 nTPM
Lung	57.2 nTPM

Astrocytes	35.6 nTPM
Brain	35.6 nTPM

B-cells	33.9 nTPM
Bone marrow	50.7 nTPM
Stomach	45.4 nTPM
PBMC	44.2 nTPM
Spleen	41.2 nTPM
Lymph node	39.2 nTPM
Adipose tissue	29.6 nTPM
Breast	25.5 nTPM
Kidney	23.8 nTPM
Colon	22.3 nTPM
Liver	16.9 nTPM

Dendritic cells	31.4 nTPM
Breast	40.9 nTPM
Adipose tissue	29.4 nTPM
PBMC	23.9 nTPM

Endothelial cells	99.0 nTPM
Pancreas	139.0 nTPM
Skeletal muscle	134.2 nTPM
Heart muscle	132.9 nTPM
Prostate	124.9 nTPM
Breast	108.6 nTPM
Ovary	104.7 nTPM
Esophagus	103.9 nTPM
Lung	99.8 nTPM
Eye	93.8 nTPM
Testis	82.1 nTPM
Endometrium	79.1 nTPM
Placenta	68.7 nTPM
Skin	61.8 nTPM
Liver	53.2 nTPM

Fibroblasts	72.9 nTPM
Heart muscle	119.7 nTPM
Prostate	112.0 nTPM
Stomach	111.4 nTPM
Adipose tissue	95.9 nTPM
Skeletal muscle	76.1 nTPM
Breast	68.9 nTPM
Esophagus	65.4 nTPM
Placenta	53.9 nTPM
Skin	50.6 nTPM
Lung	26.8 nTPM
Ovary	20.8 nTPM

Intestinal goblet cells	35.8 nTPM
Colon	51.4 nTPM
Rectum	37.2 nTPM
Small intestine	19.0 nTPM

Macrophages	49.6 nTPM
Pancreas	79.2 nTPM
Lung	59.2 nTPM
Bone marrow	56.3 nTPM
Ovary	54.1 nTPM
Testis	53.5 nTPM
Stomach	52.7 nTPM
Adipose tissue	50.0 nTPM
Endometrium	46.5 nTPM
Prostate	44.7 nTPM
Breast	44.4 nTPM
Esophagus	42.5 nTPM
Spleen	42.5 nTPM
Skeletal muscle	42.1 nTPM
PBMC	40.9 nTPM
Kidney	36.3 nTPM

Paneth cells	32.5 nTPM
Rectum	44.0 nTPM
Small intestine	33.8 nTPM
Colon	19.7 nTPM

Plasma cells	17.7 nTPM
Spleen	30.2 nTPM
Adipose tissue	23.9 nTPM
Esophagus	12.3 nTPM
Stomach	12.3 nTPM
Bone marrow	9.9 nTPM

Respiratory ciliated cells	55.9 nTPM
Bronchus	76.8 nTPM
Lung	35.0 nTPM

Smooth muscle cells	91.3 nTPM
Heart muscle	191.9 nTPM
Esophagus	133.4 nTPM
Breast	115.7 nTPM
Pancreas	101.0 nTPM
Adipose tissue	92.6 nTPM
Skeletal muscle	79.2 nTPM
Endometrium	77.8 nTPM
Prostate	62.2 nTPM
Bronchus	58.1 nTPM
Skin	50.9 nTPM
Ovary	41.6 nTPM

T-cells	33.5 nTPM
Esophagus	58.9 nTPM
Endometrium	45.3 nTPM
Stomach	42.3 nTPM
Kidney	39.7 nTPM
Skin	39.2 nTPM
Colon	37.6 nTPM
Adipose tissue	36.2 nTPM
Bone marrow	34.7 nTPM
Breast	33.8 nTPM
Skeletal muscle	33.1 nTPM
Spleen	31.4 nTPM
Liver	24.5 nTPM
Ovary	24.5 nTPM
Prostate	23.6 nTPM
PBMC	22.5 nTPM
Lymph node	22.4 nTPM
Lung	19.7 nTPM

Basal keratinocytes	38.5 nTPM
Skin	38.5 nTPM

Basal prostatic cells	80.7 nTPM
Prostate	80.7 nTPM

Basal squamous epithelial cells	25.0 nTPM
Esophagus	25.0 nTPM

Cholangiocytes	27.1 nTPM
Liver	27.1 nTPM

Undifferentiated cells	45.4 nTPM
Colon	63.9 nTPM
Rectum	49.7 nTPM
Small intestine	22.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC