Single cell type - EXOSC7 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EXOSC7
Gene descriptionⁱ Full gene name according to HGNC.	Exosome component 7
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

EXOSC7 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PARL	Presenilin associated rhomboid like	0.7290	10
MRPL15	Mitochondrial ribosomal protein L15	0.7224	10
EMG1	EMG1 N1-specific pseudouridine methyltransferase	0.6973	10
COPS6	COP9 signalosome subunit 6	0.6949	10
DCUN1D5	Defective in cullin neddylation 1 domain containing 5	0.6944	10
ZMAT5	Zinc finger matrin-type 5	0.6757	10
TMEM60	Transmembrane protein 60	0.6657	10
RRP9	Ribosomal RNA processing 9, U3 small nucleolar RNA binding protein	0.6578	10
WDR61	WD repeat domain 61	0.6545	10
PSMB5	Proteasome 20S subunit beta 5	0.6533	10
PFDN2	Prefoldin subunit 2	0.6502	10
COA7	Cytochrome c oxidase assembly factor 7 (putative)	0.6382	10
PRMT1	Protein arginine methyltransferase 1	0.6338	10
TXNDC9	Thioredoxin domain containing 9	0.6293	10
RCE1	Ras converting CAAX endopeptidase 1	0.6211	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	25.0 nTPM
Breast	35.7 nTPM
Adipose tissue	14.4 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	30.1 nTPM
Lung	30.1 nTPM

Astrocytes	16.0 nTPM
Brain	16.0 nTPM

B-cells	23.2 nTPM
Liver	36.8 nTPM
Kidney	33.4 nTPM
PBMC	29.9 nTPM
Bone marrow	27.0 nTPM
Spleen	19.7 nTPM
Stomach	19.1 nTPM
Breast	18.7 nTPM
Adipose tissue	18.6 nTPM
Colon	14.4 nTPM
Lymph node	14.0 nTPM

Dendritic cells	22.1 nTPM
Breast	26.3 nTPM
Adipose tissue	24.0 nTPM
PBMC	16.0 nTPM

Endothelial cells	24.0 nTPM
Placenta	37.5 nTPM
Skin	37.4 nTPM
Pancreas	30.9 nTPM
Prostate	30.8 nTPM
Ovary	27.9 nTPM
Breast	26.4 nTPM
Testis	23.1 nTPM
Esophagus	21.6 nTPM
Skeletal muscle	20.8 nTPM
Liver	19.2 nTPM
Endometrium	18.4 nTPM
Eye	17.8 nTPM
Lung	15.6 nTPM
Heart muscle	8.5 nTPM

Fibroblasts	32.7 nTPM
Ovary	54.3 nTPM
Breast	45.3 nTPM
Placenta	44.5 nTPM
Skin	40.9 nTPM
Prostate	35.9 nTPM
Adipose tissue	30.0 nTPM
Skeletal muscle	27.1 nTPM
Esophagus	24.3 nTPM
Heart muscle	22.7 nTPM
Stomach	17.8 nTPM
Lung	16.8 nTPM

Intestinal goblet cells	19.3 nTPM
Colon	20.1 nTPM
Small intestine	19.7 nTPM
Rectum	18.1 nTPM

Macrophages	17.4 nTPM
Pancreas	30.7 nTPM
Ovary	28.7 nTPM
Kidney	28.0 nTPM
Breast	23.8 nTPM
Testis	19.7 nTPM
Bone marrow	18.8 nTPM
Endometrium	18.1 nTPM
Lung	17.8 nTPM
Adipose tissue	17.2 nTPM
Prostate	13.8 nTPM
Esophagus	12.6 nTPM
Spleen	12.5 nTPM
Skeletal muscle	10.7 nTPM
Stomach	8.8 nTPM
PBMC	0.0 nTPM

Paneth cells	10.3 nTPM
Rectum	19.8 nTPM
Small intestine	11.3 nTPM
Colon	0.0 nTPM

Plasma cells	19.4 nTPM
Bone marrow	28.0 nTPM
Spleen	26.1 nTPM
Stomach	24.4 nTPM
Adipose tissue	12.2 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	34.3 nTPM
Bronchus	40.9 nTPM
Lung	27.7 nTPM

Smooth muscle cells	53.9 nTPM
Bronchus	305.1 nTPM
Pancreas	45.3 nTPM
Ovary	41.4 nTPM
Breast	36.8 nTPM
Skin	33.4 nTPM
Prostate	27.5 nTPM
Adipose tissue	22.8 nTPM
Heart muscle	22.0 nTPM
Esophagus	20.1 nTPM
Endometrium	19.8 nTPM
Skeletal muscle	18.1 nTPM

T-cells	26.2 nTPM
Ovary	44.5 nTPM
Lung	38.0 nTPM
Kidney	36.9 nTPM
Skin	30.4 nTPM
Liver	28.4 nTPM
Bone marrow	28.2 nTPM
PBMC	27.3 nTPM
Esophagus	26.2 nTPM
Stomach	24.2 nTPM
Prostate	23.6 nTPM
Lymph node	22.3 nTPM
Spleen	22.3 nTPM
Adipose tissue	22.1 nTPM
Breast	21.2 nTPM
Endometrium	18.6 nTPM
Skeletal muscle	16.2 nTPM
Colon	15.7 nTPM

Basal keratinocytes	61.8 nTPM
Skin	61.8 nTPM

Basal prostatic cells	68.8 nTPM
Prostate	68.8 nTPM

Basal respiratory cells	97.2 nTPM
Bronchus	97.2 nTPM

Basal squamous epithelial cells	47.3 nTPM
Esophagus	47.3 nTPM

Undifferentiated cells	24.3 nTPM
Colon	25.8 nTPM
Rectum	24.4 nTPM
Small intestine	22.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC