Single cell type - RBMS2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RBMS2
Gene descriptionⁱ Full gene name according to HGNC.	RNA binding motif single stranded interacting protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Adipocytes & Endothelial cells - Angiogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Adipocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Adipocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RBMS2 is part of cluster 14 Adipocytes & Endothelial cells - Angiogenesis with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CLEC14A	C-type lectin domain containing 14A	0.5782	14
EIF2AK2	Eukaryotic translation initiation factor 2 alpha kinase 2	0.5757	14
ANXA3	Annexin A3	0.5491	16
LIFR	LIF receptor subunit alpha	0.5478	14
HIF3A	Hypoxia inducible factor 3 subunit alpha	0.5438	14
FMO2	Flavin containing dimethylaniline monoxygenase 2	0.5414	14
EPAS1	Endothelial PAS domain protein 1	0.5372	14
RAPGEF3	Rap guanine nucleotide exchange factor 3	0.5343	14
HEY1	Hes related family bHLH transcription factor with YRPW motif 1	0.5338	14
CDH5	Cadherin 5	0.5326	14
FGD5	FYVE, RhoGEF and PH domain containing 5	0.5325	14
F8	Coagulation factor VIII	0.5288	14
NPR1	Natriuretic peptide receptor 1	0.5274	14
IFI44	Interferon induced protein 44	0.5222	14
HSPA12B	Heat shock protein family A (Hsp70) member 12B	0.5208	14

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	41.7 nTPM
Lung	41.7 nTPM

Alveolar cells type 2	20.5 nTPM
Lung	20.5 nTPM

Astrocytes	34.6 nTPM
Brain	34.6 nTPM

B-cells	1.5 nTPM
Adipose tissue	4.0 nTPM
Liver	3.3 nTPM
Bone marrow	1.7 nTPM
Spleen	1.7 nTPM
PBMC	1.4 nTPM
Breast	1.3 nTPM
Lymph node	0.9 nTPM
Stomach	0.9 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM

Basal keratinocytes	3.7 nTPM
Skin	3.7 nTPM

Dendritic cells	7.0 nTPM
PBMC	8.0 nTPM
Breast	7.6 nTPM
Adipose tissue	5.5 nTPM

Endothelial cells	47.9 nTPM
Skeletal muscle	87.9 nTPM
Liver	78.0 nTPM
Heart muscle	70.3 nTPM
Esophagus	56.9 nTPM
Ovary	52.5 nTPM
Breast	47.9 nTPM
Pancreas	46.4 nTPM
Testis	45.3 nTPM
Placenta	44.4 nTPM
Endometrium	40.6 nTPM
Eye	34.8 nTPM
Prostate	28.7 nTPM
Lung	24.9 nTPM
Skin	11.8 nTPM

Fibroblasts	16.9 nTPM
Heart muscle	31.4 nTPM
Stomach	31.2 nTPM
Esophagus	29.4 nTPM
Skeletal muscle	17.9 nTPM
Adipose tissue	16.6 nTPM
Placenta	14.1 nTPM
Ovary	14.0 nTPM
Breast	13.9 nTPM
Lung	7.8 nTPM
Prostate	7.2 nTPM
Skin	2.8 nTPM

Intestinal goblet cells	5.9 nTPM
Rectum	11.3 nTPM
Small intestine	4.2 nTPM
Colon	2.2 nTPM

Macrophages	11.2 nTPM
Lung	24.8 nTPM
Ovary	21.6 nTPM
Esophagus	15.8 nTPM
Skeletal muscle	14.4 nTPM
Adipose tissue	14.4 nTPM
Endometrium	12.7 nTPM
Prostate	12.6 nTPM
Testis	9.8 nTPM
Breast	9.0 nTPM
Stomach	8.8 nTPM
Spleen	7.2 nTPM
Kidney	6.1 nTPM
Pancreas	5.1 nTPM
Bone marrow	5.0 nTPM
PBMC	0.0 nTPM

Paneth cells	11.5 nTPM
Small intestine	18.8 nTPM
Rectum	12.4 nTPM
Colon	3.3 nTPM

Plasma cells	0.8 nTPM
Adipose tissue	3.3 nTPM
Stomach	0.5 nTPM
Spleen	0.3 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	6.8 nTPM
Lung	7.3 nTPM
Bronchus	6.3 nTPM

Smooth muscle cells	15.5 nTPM
Adipose tissue	28.4 nTPM
Esophagus	23.3 nTPM
Skeletal muscle	18.3 nTPM
Endometrium	18.1 nTPM
Ovary	16.6 nTPM
Breast	15.3 nTPM
Bronchus	14.1 nTPM
Pancreas	13.1 nTPM
Heart muscle	11.1 nTPM
Prostate	9.4 nTPM
Skin	2.4 nTPM

T-cells	2.5 nTPM
Skeletal muscle	7.7 nTPM
Lung	7.6 nTPM
Endometrium	6.6 nTPM
Adipose tissue	4.8 nTPM
Breast	3.0 nTPM
Liver	2.7 nTPM
Kidney	2.0 nTPM
PBMC	1.4 nTPM
Bone marrow	1.3 nTPM
Stomach	1.2 nTPM
Colon	1.0 nTPM
Spleen	1.0 nTPM
Skin	0.9 nTPM
Lymph node	0.9 nTPM
Prostate	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM

Cholangiocytes	12.8 nTPM
Liver	12.8 nTPM

Collecting duct cells	12.9 nTPM
Kidney	12.9 nTPM

Cone photoreceptor cells	10.4 nTPM
Eye	10.4 nTPM

Cytotrophoblasts	19.8 nTPM
Placenta	19.8 nTPM

Undifferentiated cells	7.0 nTPM
Rectum	10.4 nTPM
Small intestine	6.3 nTPM
Colon	4.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC