Single cell type - ANKRD13A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ANKRD13A
Gene descriptionⁱ Full gene name according to HGNC.	Ankyrin repeat domain 13A
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	B-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (fHDF/TERT166, HBF TERT88)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ANKRD13A is part of cluster 57 B-cells - Immune response with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
AIM2	Absent in melanoma 2	0.7122	57
IGLV5-37	Immunoglobulin lambda variable 5-37	0.6800	57
CLEC17A	C-type lectin domain containing 17A	0.6704	57
SP140	SP140 nuclear body protein	0.6544	57
PAX5	Paired box 5	0.6539	57
CR2	Complement C3d receptor 2	0.6506	57
CXCR5	C-X-C motif chemokine receptor 5	0.6490	57
IGHV1-58	Immunoglobulin heavy variable 1-58	0.6481	57
LCN8	Lipocalin 8	0.6471	57
LCN10	Lipocalin 10	0.6391	57
BANK1	B cell scaffold protein with ankyrin repeats 1	0.6291	57
IGHV7-81	Immunoglobulin heavy variable 7-81 (non-functional)	0.6283	57
FCRL2	Fc receptor like 2	0.6280	57
VPREB3	V-set pre-B cell surrogate light chain 3	0.6237	57
FCRL1	Fc receptor like 1	0.6237	57

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	15.7 nTPM
Adipose tissue	18.8 nTPM
Breast	12.6 nTPM

Alveolar cells type 1	48.1 nTPM
Lung	48.1 nTPM

Alveolar cells type 2	32.5 nTPM
Lung	32.5 nTPM

Astrocytes	13.4 nTPM
Brain	13.4 nTPM

Basal keratinocytes	29.3 nTPM
Skin	29.3 nTPM

B-cells	75.5 nTPM
Adipose tissue	125.3 nTPM
Lymph node	115.8 nTPM
Stomach	114.9 nTPM
Bone marrow	89.9 nTPM
Spleen	88.6 nTPM
Colon	70.3 nTPM
PBMC	55.7 nTPM
Breast	40.2 nTPM
Kidney	33.4 nTPM
Liver	21.1 nTPM

Dendritic cells	31.2 nTPM
PBMC	35.8 nTPM
Adipose tissue	30.5 nTPM
Breast	27.4 nTPM

Endothelial cells	14.9 nTPM
Ovary	21.1 nTPM
Eye	20.3 nTPM
Heart muscle	18.6 nTPM
Esophagus	17.1 nTPM
Skeletal muscle	16.7 nTPM
Testis	16.6 nTPM
Liver	15.6 nTPM
Lung	15.6 nTPM
Skin	15.2 nTPM
Breast	15.2 nTPM
Endometrium	13.5 nTPM
Placenta	11.9 nTPM
Prostate	7.2 nTPM
Pancreas	3.9 nTPM

Fibroblasts	15.5 nTPM
Stomach	22.3 nTPM
Heart muscle	21.6 nTPM
Esophagus	20.3 nTPM
Skin	18.9 nTPM
Skeletal muscle	15.2 nTPM
Adipose tissue	14.3 nTPM
Placenta	13.4 nTPM
Ovary	12.7 nTPM
Breast	11.7 nTPM
Lung	11.1 nTPM
Prostate	9.1 nTPM

Intestinal goblet cells	9.4 nTPM
Rectum	13.6 nTPM
Small intestine	11.0 nTPM
Colon	3.6 nTPM

Macrophages	33.7 nTPM
Spleen	77.8 nTPM
Stomach	61.5 nTPM
Bone marrow	52.4 nTPM
Skeletal muscle	39.9 nTPM
Esophagus	39.3 nTPM
Adipose tissue	38.4 nTPM
Kidney	34.8 nTPM
Ovary	27.8 nTPM
Endometrium	26.6 nTPM
Lung	26.3 nTPM
Breast	22.3 nTPM
Testis	20.3 nTPM
Prostate	16.0 nTPM
PBMC	13.6 nTPM
Pancreas	7.7 nTPM

Paneth cells	12.5 nTPM
Rectum	19.9 nTPM
Colon	9.9 nTPM
Small intestine	7.5 nTPM

Plasma cells	33.0 nTPM
Stomach	48.2 nTPM
Spleen	41.3 nTPM
Bone marrow	29.7 nTPM
Esophagus	24.6 nTPM
Adipose tissue	21.3 nTPM

Respiratory ciliated cells	37.6 nTPM
Bronchus	47.6 nTPM
Lung	27.7 nTPM

Smooth muscle cells	18.0 nTPM
Ovary	31.6 nTPM
Pancreas	28.4 nTPM
Esophagus	27.9 nTPM
Skeletal muscle	20.0 nTPM
Prostate	16.8 nTPM
Skin	16.1 nTPM
Bronchus	13.2 nTPM
Adipose tissue	12.0 nTPM
Breast	11.9 nTPM
Heart muscle	9.9 nTPM
Endometrium	9.8 nTPM

Cholangiocytes	28.6 nTPM
Liver	28.6 nTPM

Collecting duct cells	57.0 nTPM
Kidney	57.0 nTPM

Cone photoreceptor cells	14.6 nTPM
Eye	14.6 nTPM

Cytotrophoblasts	16.9 nTPM
Placenta	16.9 nTPM

T-cells	31.8 nTPM
Esophagus	91.7 nTPM
Skin	49.2 nTPM
Spleen	41.5 nTPM
Lymph node	39.4 nTPM
Adipose tissue	35.2 nTPM
Skeletal muscle	34.3 nTPM
Stomach	30.2 nTPM
Bone marrow	29.6 nTPM
Liver	27.2 nTPM
PBMC	25.2 nTPM
Breast	25.2 nTPM
Colon	24.2 nTPM
Endometrium	22.4 nTPM
Ovary	22.3 nTPM
Kidney	19.1 nTPM
Prostate	14.2 nTPM
Lung	9.1 nTPM

Undifferentiated cells	17.0 nTPM
Rectum	24.4 nTPM
Small intestine	13.9 nTPM
Colon	12.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC