Single cell type - STXBP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	STXBP2
Gene descriptionⁱ Full gene name according to HGNC.	Syntaxin binding protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Monocytes & Neutrophils - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (monocytes, Kupffer cells, Macrophages)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (non-classical monocyte, intermediate monocyte, classical monocyte, neutrophil, eosinophil, basophil, myeloid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HMC-1, U-937)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (monocytes, Kupffer cells, Macrophages)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

STXBP2 is part of cluster 19 Monocytes & Neutrophils - Innate immune response with confidenceⁱ 1
175 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LILRA1	Leukocyte immunoglobulin like receptor A1	0.7557	19
C19orf38	Chromosome 19 open reading frame 38	0.7439	19
MEFV	MEFV innate immuity regulator, pyrin	0.7362	19
FCN1	Ficolin 1	0.7296	19
LILRA2	Leukocyte immunoglobulin like receptor A2	0.7287	19
CLEC12A	C-type lectin domain family 12 member A	0.7283	19
ADGRE1	Adhesion G protein-coupled receptor E1	0.7239	19
S100A12	S100 calcium binding protein A12	0.7178	19
NFAM1	NFAT activating protein with ITAM motif 1	0.7100	19
PRAM1	PML-RARA regulated adaptor molecule 1	0.7061	19
VSTM1	V-set and transmembrane domain containing 1	0.6897	19
CEACAM4	CEA cell adhesion molecule 4	0.6841	19
LST1	Leukocyte specific transcript 1	0.6762	19
HK3	Hexokinase 3	0.6739	19
S100Z	S100 calcium binding protein Z	0.6713	19

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	2.1 nTPM
Breast	3.5 nTPM
Adipose tissue	0.9 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	7.7 nTPM
Lung	7.7 nTPM

Astrocytes	0.7 nTPM
Brain	0.7 nTPM

B-cells	44.1 nTPM
Liver	53.8 nTPM
Colon	51.1 nTPM
Spleen	49.5 nTPM
Kidney	47.6 nTPM
Stomach	47.2 nTPM
Lymph node	45.8 nTPM
Bone marrow	45.8 nTPM
PBMC	42.8 nTPM
Breast	40.2 nTPM
Adipose tissue	17.1 nTPM

Dendritic cells	56.2 nTPM
PBMC	71.8 nTPM
Breast	59.4 nTPM
Adipose tissue	37.5 nTPM

Endothelial cells	6.7 nTPM
Liver	22.0 nTPM
Placenta	19.9 nTPM
Testis	12.2 nTPM
Pancreas	7.7 nTPM
Prostate	6.9 nTPM
Eye	6.5 nTPM
Breast	5.5 nTPM
Skin	4.2 nTPM
Endometrium	4.0 nTPM
Esophagus	2.1 nTPM
Skeletal muscle	1.8 nTPM
Ovary	0.8 nTPM
Heart muscle	0.5 nTPM
Lung	0.0 nTPM

Fibroblasts	5.7 nTPM
Placenta	43.5 nTPM
Prostate	4.0 nTPM
Breast	3.6 nTPM
Lung	3.4 nTPM
Heart muscle	2.3 nTPM
Skin	2.3 nTPM
Stomach	1.5 nTPM
Esophagus	0.8 nTPM
Skeletal muscle	0.7 nTPM
Ovary	0.7 nTPM
Adipose tissue	0.1 nTPM

Intestinal goblet cells	108.2 nTPM
Colon	148.7 nTPM
Small intestine	103.0 nTPM
Rectum	73.0 nTPM

Macrophages	249.1 nTPM
Kidney	686.7 nTPM
Stomach	445.4 nTPM
PBMC	422.8 nTPM
Bone marrow	411.1 nTPM
Spleen	405.4 nTPM
Skeletal muscle	253.6 nTPM
Pancreas	214.4 nTPM
Adipose tissue	185.7 nTPM
Prostate	183.5 nTPM
Ovary	116.2 nTPM
Testis	108.1 nTPM
Endometrium	94.0 nTPM
Breast	85.4 nTPM
Esophagus	75.5 nTPM
Lung	48.8 nTPM

Paneth cells	152.6 nTPM
Colon	237.2 nTPM
Small intestine	142.7 nTPM
Rectum	77.8 nTPM

Plasma cells	54.7 nTPM
Stomach	67.2 nTPM
Bone marrow	64.2 nTPM
Spleen	60.5 nTPM
Esophagus	49.4 nTPM
Adipose tissue	32.2 nTPM

Respiratory ciliated cells	42.5 nTPM
Bronchus	79.1 nTPM
Lung	5.8 nTPM

Smooth muscle cells	8.6 nTPM
Bronchus	48.9 nTPM
Ovary	21.5 nTPM
Pancreas	8.7 nTPM
Prostate	6.9 nTPM
Breast	3.4 nTPM
Endometrium	2.5 nTPM
Skin	1.4 nTPM
Skeletal muscle	0.3 nTPM
Heart muscle	0.2 nTPM
Adipose tissue	0.2 nTPM
Esophagus	0.0 nTPM

T-cells	47.7 nTPM
Kidney	70.5 nTPM
Liver	66.7 nTPM
Stomach	66.2 nTPM
Colon	61.3 nTPM
Bone marrow	60.7 nTPM
Spleen	58.6 nTPM
Ovary	55.6 nTPM
Breast	50.8 nTPM
PBMC	49.6 nTPM
Esophagus	39.3 nTPM
Skin	39.2 nTPM
Lymph node	38.8 nTPM
Prostate	37.9 nTPM
Skeletal muscle	35.5 nTPM
Adipose tissue	30.1 nTPM
Endometrium	27.0 nTPM
Lung	22.8 nTPM

Basal keratinocytes	23.6 nTPM
Skin	23.6 nTPM

Basal prostatic cells	48.2 nTPM
Prostate	48.2 nTPM

Basal respiratory cells	105.1 nTPM
Bronchus	105.1 nTPM

Basal squamous epithelial cells	18.8 nTPM
Esophagus	18.8 nTPM

Undifferentiated cells	79.3 nTPM
Colon	112.8 nTPM
Small intestine	62.9 nTPM
Rectum	62.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC