Single cell type - NFKB2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NFKB2
Gene descriptionⁱ Full gene name according to HGNC.	Nuclear factor kappa B subunit 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes FDA approved drug targets Human disease related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Langerhans cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HDLM-2, Karpas-707)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Langerhans cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NFKB2 is part of cluster 41 Macrophages - Immune response with confidenceⁱ 1
307 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
BIRC3	Baculoviral IAP repeat containing 3	0.6768	3
ACOT9	Acyl-CoA thioesterase 9	0.6378	10
NFKBID	NFKB inhibitor delta	0.5904	41
BAX	BCL2 associated X, apoptosis regulator	0.5748	10
KDM6B	Lysine demethylase 6B	0.5733	41
BCL2A1	BCL2 related protein A1	0.5639	41
NFKBIE	NFKB inhibitor epsilon	0.5509	41
C17orf49	Chromosome 17 open reading frame 49	0.5437	10
RBM39	RNA binding motif protein 39	0.5406	52
CD83	CD83 molecule	0.5374	41
GPBP1	GC-rich promoter binding protein 1	0.5326	22
RASGEF1B	RasGEF domain family member 1B	0.5321	41
PNPLA8	Patatin like phospholipase domain containing 8	0.5280	41
GPR132	G protein-coupled receptor 132	0.5270	41
ANGPTL6	Angiopoietin like 6	0.5230	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	20.8 nTPM
Adipose tissue	26.2 nTPM
Breast	15.3 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	8.8 nTPM
Lung	8.8 nTPM

Astrocytes	3.3 nTPM
Brain	3.3 nTPM

B-cells	88.3 nTPM
Colon	180.5 nTPM
Adipose tissue	147.9 nTPM
Breast	103.0 nTPM
Spleen	101.8 nTPM
Kidney	80.9 nTPM
Bone marrow	65.4 nTPM
PBMC	62.8 nTPM
Lymph node	60.7 nTPM
Stomach	42.7 nTPM
Liver	37.4 nTPM

Dendritic cells	39.0 nTPM
Adipose tissue	54.3 nTPM
Breast	42.7 nTPM
PBMC	20.0 nTPM

Endothelial cells	26.1 nTPM
Skin	62.6 nTPM
Prostate	56.8 nTPM
Skeletal muscle	41.4 nTPM
Ovary	34.6 nTPM
Lung	31.2 nTPM
Pancreas	23.1 nTPM
Endometrium	19.1 nTPM
Esophagus	18.6 nTPM
Eye	17.0 nTPM
Breast	16.3 nTPM
Placenta	13.7 nTPM
Liver	11.9 nTPM
Testis	10.9 nTPM
Heart muscle	9.0 nTPM

Fibroblasts	26.0 nTPM
Prostate	91.6 nTPM
Skin	54.8 nTPM
Stomach	32.7 nTPM
Skeletal muscle	26.8 nTPM
Esophagus	18.5 nTPM
Adipose tissue	14.5 nTPM
Ovary	14.3 nTPM
Breast	12.5 nTPM
Placenta	9.7 nTPM
Lung	7.8 nTPM
Heart muscle	3.4 nTPM

Intestinal goblet cells	30.4 nTPM
Colon	64.4 nTPM
Small intestine	17.9 nTPM
Rectum	9.1 nTPM

Macrophages	52.5 nTPM
Adipose tissue	161.6 nTPM
Stomach	108.4 nTPM
Spleen	98.5 nTPM
Prostate	95.2 nTPM
Skeletal muscle	72.0 nTPM
Endometrium	59.5 nTPM
Breast	54.7 nTPM
Bone marrow	28.7 nTPM
Kidney	28.0 nTPM
Pancreas	25.5 nTPM
Esophagus	18.9 nTPM
Testis	12.8 nTPM
Lung	11.6 nTPM
Ovary	11.5 nTPM
PBMC	0.0 nTPM

Paneth cells	37.4 nTPM
Colon	85.7 nTPM
Small intestine	15.0 nTPM
Rectum	11.6 nTPM

Plasma cells	49.1 nTPM
Stomach	82.5 nTPM
Adipose tissue	81.3 nTPM
Bone marrow	33.0 nTPM
Esophagus	24.6 nTPM
Spleen	24.3 nTPM

Respiratory ciliated cells	19.9 nTPM
Bronchus	38.4 nTPM
Lung	1.5 nTPM

Smooth muscle cells	43.6 nTPM
Bronchus	257.3 nTPM
Skin	56.8 nTPM
Skeletal muscle	32.6 nTPM
Prostate	28.8 nTPM
Esophagus	18.6 nTPM
Ovary	18.5 nTPM
Endometrium	17.6 nTPM
Adipose tissue	16.3 nTPM
Breast	16.2 nTPM
Pancreas	15.7 nTPM
Heart muscle	1.4 nTPM

T-cells	54.6 nTPM
Colon	137.3 nTPM
Prostate	123.0 nTPM
Spleen	82.4 nTPM
Endometrium	71.6 nTPM
Skin	68.2 nTPM
Breast	58.7 nTPM
Adipose tissue	57.7 nTPM
Lymph node	48.9 nTPM
Skeletal muscle	47.0 nTPM
Stomach	44.0 nTPM
Bone marrow	42.3 nTPM
Kidney	27.4 nTPM
Esophagus	26.2 nTPM
Liver	24.6 nTPM
Ovary	24.5 nTPM
Lung	24.3 nTPM
PBMC	21.0 nTPM

Basal keratinocytes	43.5 nTPM
Skin	43.5 nTPM

Basal prostatic cells	59.3 nTPM
Prostate	59.3 nTPM

Basal respiratory cells	41.2 nTPM
Bronchus	41.2 nTPM

Basal squamous epithelial cells	34.7 nTPM
Esophagus	34.7 nTPM

Undifferentiated cells	17.9 nTPM
Colon	32.4 nTPM
Small intestine	11.6 nTPM
Rectum	9.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC