Single cell type - DNAJC10 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DNAJC10
Gene descriptionⁱ Full gene name according to HGNC.	DnaJ heat shock protein family (Hsp40) member C10
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endometrium - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DNAJC10 is part of cluster 44 Endometrium - Transcription with confidenceⁱ 1
491 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CASTOR2	Cytosolic arginine sensor for mTORC1 subunit 2	0.5454	44
KRTAP4-7	Keratin associated protein 4-7	0.5392	44
CLEC20A	C-type lectin domain containing 20A	0.5080	44
TMEFF1	Transmembrane protein with EGF like and two follistatin like domains 1	0.4986	36
TBC1D3L	TBC1 domain family member 3L	0.4975	44
OR51L1	Olfactory receptor family 51 subfamily L member 1	0.4870	44
AL139260.3	Novel protein	0.4851	44
PGR	Progesterone receptor	0.4843	36
MMP26	Matrix metallopeptidase 26	0.4836	44
TRMT9B	TRNA methyltransferase 9B (putative)	0.4793	44
KRTAP4-9	Keratin associated protein 4-9	0.4757	44
AVPR1B	Arginine vasopressin receptor 1B	0.4705	44
BX276092.9	Chromosome X open reading frame 49-like	0.4695	44
AC015802.6	Novel protein	0.4683	44
KRTAP4-8	Keratin associated protein 4-8	0.4669	44

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	49.6 nTPM
Breast	53.0 nTPM
Adipose tissue	46.3 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	22.0 nTPM
Lung	22.0 nTPM

Astrocytes	34.3 nTPM
Brain	34.3 nTPM

B-cells	79.9 nTPM
PBMC	127.0 nTPM
Bone marrow	89.1 nTPM
Stomach	86.3 nTPM
Spleen	86.2 nTPM
Adipose tissue	79.7 nTPM
Breast	78.8 nTPM
Lymph node	69.3 nTPM
Kidney	66.6 nTPM
Liver	63.0 nTPM
Colon	52.7 nTPM

Dendritic cells	22.9 nTPM
Adipose tissue	25.9 nTPM
Breast	22.9 nTPM
PBMC	20.0 nTPM

Endothelial cells	51.9 nTPM
Lung	102.9 nTPM
Heart muscle	76.8 nTPM
Ovary	70.6 nTPM
Pancreas	69.5 nTPM
Endometrium	60.0 nTPM
Breast	46.9 nTPM
Placenta	46.0 nTPM
Skeletal muscle	39.8 nTPM
Eye	39.7 nTPM
Liver	37.6 nTPM
Testis	36.1 nTPM
Prostate	34.3 nTPM
Skin	34.1 nTPM
Esophagus	32.4 nTPM

Fibroblasts	49.4 nTPM
Lung	82.7 nTPM
Heart muscle	65.7 nTPM
Skeletal muscle	51.1 nTPM
Breast	50.4 nTPM
Adipose tissue	50.0 nTPM
Stomach	47.5 nTPM
Ovary	47.4 nTPM
Esophagus	46.8 nTPM
Skin	43.1 nTPM
Prostate	30.8 nTPM
Placenta	28.3 nTPM

Intestinal goblet cells	117.3 nTPM
Colon	173.0 nTPM
Rectum	90.2 nTPM
Small intestine	88.8 nTPM

Macrophages	40.6 nTPM
Lung	57.8 nTPM
Endometrium	55.3 nTPM
Spleen	55.0 nTPM
Skeletal muscle	44.3 nTPM
Stomach	43.9 nTPM
Esophagus	42.5 nTPM
Bone marrow	42.5 nTPM
Adipose tissue	42.3 nTPM
Kidney	37.8 nTPM
Breast	37.5 nTPM
Testis	36.0 nTPM
Prostate	29.8 nTPM
Ovary	28.5 nTPM
Pancreas	28.0 nTPM
PBMC	27.3 nTPM

Paneth cells	19.9 nTPM
Small intestine	30.0 nTPM
Rectum	16.4 nTPM
Colon	13.2 nTPM

Plasma cells	67.9 nTPM
Spleen	111.8 nTPM
Bone marrow	70.9 nTPM
Stomach	67.8 nTPM
Esophagus	49.4 nTPM
Adipose tissue	39.4 nTPM

Respiratory ciliated cells	132.0 nTPM
Lung	170.5 nTPM
Bronchus	93.5 nTPM

Smooth muscle cells	53.8 nTPM
Heart muscle	138.2 nTPM
Breast	66.7 nTPM
Endometrium	59.6 nTPM
Adipose tissue	47.7 nTPM
Bronchus	46.1 nTPM
Ovary	43.1 nTPM
Pancreas	40.1 nTPM
Prostate	39.7 nTPM
Esophagus	38.8 nTPM
Skin	37.6 nTPM
Skeletal muscle	34.2 nTPM

T-cells	28.8 nTPM
Lung	71.4 nTPM
Endometrium	46.7 nTPM
Esophagus	39.3 nTPM
Stomach	29.5 nTPM
Prostate	28.4 nTPM
PBMC	28.4 nTPM
Skeletal muscle	27.8 nTPM
Spleen	27.5 nTPM
Bone marrow	26.3 nTPM
Colon	24.7 nTPM
Breast	23.7 nTPM
Adipose tissue	23.2 nTPM
Skin	23.0 nTPM
Lymph node	21.5 nTPM
Kidney	19.1 nTPM
Liver	18.4 nTPM
Ovary	11.1 nTPM

Basal keratinocytes	17.2 nTPM
Skin	17.2 nTPM

Basal prostatic cells	21.1 nTPM
Prostate	21.1 nTPM

Basal respiratory cells	18.8 nTPM
Bronchus	18.8 nTPM

Basal squamous epithelial cells	18.2 nTPM
Esophagus	18.2 nTPM

Undifferentiated cells	21.5 nTPM
Colon	25.2 nTPM
Small intestine	19.8 nTPM
Rectum	19.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC