Single cell type - FAM76B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM76B
Gene descriptionⁱ Full gene name according to HGNC.	Family with sequence similarity 76 member B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FAM76B is part of cluster 25 Spermatids - Spermatogenesis with confidenceⁱ 1
458 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PHF2	PHD finger protein 2	0.8204	25
ZDHHC19	Zinc finger DHHC-type palmitoyltransferase 19	0.7924	25
RGS22	Regulator of G protein signaling 22	0.7850	25
TMEM239	Transmembrane protein 239	0.7815	25
LRRD1	Leucine rich repeats and death domain containing 1	0.7811	25
CRISP1	Cysteine rich secretory protein 1	0.7791	25
TMEM210	Transmembrane protein 210	0.7790	25
TPPP2	Tubulin polymerization promoting protein family member 2	0.7767	25
MROH7	Maestro heat like repeat family member 7	0.7762	25
SPATC1	Spermatogenesis and centriole associated 1	0.7762	25
C10orf62	Chromosome 10 open reading frame 62	0.7745	25
KIF2C	Kinesin family member 2C	0.7729	25
ZFAND4	Zinc finger AN1-type containing 4	0.7712	25
GSG1	Germ cell associated 1	0.7711	25
SMKR1	Small lysine rich protein 1	0.7674	25

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	27.9 nTPM
Adipose tissue	31.1 nTPM
Breast	24.7 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	16.5 nTPM
Lung	16.5 nTPM

Astrocytes	14.7 nTPM
Brain	14.7 nTPM

B-cells	41.5 nTPM
Adipose tissue	91.2 nTPM
Colon	55.9 nTPM
Lymph node	55.3 nTPM
Spleen	40.8 nTPM
Breast	40.2 nTPM
Stomach	40.0 nTPM
Kidney	33.4 nTPM
PBMC	22.8 nTPM
Bone marrow	19.6 nTPM
Liver	16.2 nTPM

Dendritic cells	28.9 nTPM
Adipose tissue	50.5 nTPM
Breast	32.1 nTPM
PBMC	4.0 nTPM

Endothelial cells	19.2 nTPM
Heart muscle	40.3 nTPM
Lung	24.9 nTPM
Breast	24.7 nTPM
Ovary	22.0 nTPM
Endometrium	21.2 nTPM
Liver	20.2 nTPM
Skeletal muscle	20.1 nTPM
Prostate	19.0 nTPM
Testis	17.4 nTPM
Skin	17.0 nTPM
Esophagus	15.5 nTPM
Eye	14.6 nTPM
Placenta	8.6 nTPM
Pancreas	3.9 nTPM

Fibroblasts	14.9 nTPM
Heart muscle	27.7 nTPM
Adipose tissue	19.8 nTPM
Breast	19.2 nTPM
Esophagus	16.5 nTPM
Skeletal muscle	13.6 nTPM
Prostate	13.5 nTPM
Skin	12.9 nTPM
Lung	11.1 nTPM
Ovary	10.7 nTPM
Stomach	10.4 nTPM
Placenta	8.3 nTPM

Intestinal goblet cells	14.0 nTPM
Colon	15.7 nTPM
Small intestine	13.8 nTPM
Rectum	12.4 nTPM

Macrophages	20.0 nTPM
Adipose tissue	36.7 nTPM
Skeletal muscle	27.7 nTPM
Endometrium	27.3 nTPM
Testis	25.0 nTPM
Breast	24.9 nTPM
Spleen	23.9 nTPM
Bone marrow	23.7 nTPM
Esophagus	23.6 nTPM
Stomach	17.6 nTPM
Kidney	17.5 nTPM
Prostate	17.2 nTPM
Lung	16.0 nTPM
Ovary	13.2 nTPM
Pancreas	5.1 nTPM
PBMC	0.0 nTPM

Paneth cells	16.0 nTPM
Small intestine	26.3 nTPM
Colon	13.2 nTPM
Rectum	8.6 nTPM

Plasma cells	16.2 nTPM
Adipose tissue	27.7 nTPM
Spleen	16.9 nTPM
Bone marrow	13.2 nTPM
Esophagus	12.3 nTPM
Stomach	10.8 nTPM

Respiratory ciliated cells	12.3 nTPM
Bronchus	12.9 nTPM
Lung	11.7 nTPM

Smooth muscle cells	21.3 nTPM
Heart muscle	45.5 nTPM
Ovary	28.9 nTPM
Endometrium	26.6 nTPM
Adipose tissue	24.9 nTPM
Bronchus	19.9 nTPM
Skeletal muscle	18.3 nTPM
Breast	17.7 nTPM
Skin	17.5 nTPM
Esophagus	17.0 nTPM
Prostate	11.6 nTPM
Pancreas	5.9 nTPM

T-cells	26.4 nTPM
Adipose tissue	57.2 nTPM
Lymph node	42.3 nTPM
Ovary	40.0 nTPM
Skeletal muscle	35.3 nTPM
Endometrium	32.2 nTPM
Breast	32.2 nTPM
Prostate	28.4 nTPM
Colon	24.7 nTPM
Lung	24.3 nTPM
Skin	21.2 nTPM
Spleen	21.2 nTPM
Stomach	20.4 nTPM
PBMC	16.4 nTPM
Bone marrow	15.3 nTPM
Liver	14.3 nTPM
Esophagus	13.1 nTPM
Kidney	10.9 nTPM

Basal prostatic cells	12.5 nTPM
Prostate	12.5 nTPM

Basal respiratory cells	8.4 nTPM
Bronchus	8.4 nTPM

Collecting duct cells	5.5 nTPM
Kidney	5.5 nTPM

Cone photoreceptor cells	27.1 nTPM
Eye	27.1 nTPM

Undifferentiated cells	10.8 nTPM
Small intestine	13.6 nTPM
Rectum	10.3 nTPM
Colon	8.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC