Single cell type - EPB41L2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EPB41L2
Gene descriptionⁱ Full gene name according to HGNC.	Erythrocyte membrane protein band 4.1 like 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	25

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Photoreceptor cells - Phototransduction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Rod photoreceptor cells, Muller glia cells, Microglial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Rod photoreceptor cells, Muller glia cells, Microglial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

EPB41L2 is part of cluster 46 Photoreceptor cells - Phototransduction with confidenceⁱ 1
209 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FAM161A	FAM161 centrosomal protein A	0.7603	46
PPEF2	Protein phosphatase with EF-hand domain 2	0.7558	46
GUCY2F	Guanylate cyclase 2F, retinal	0.7554	46
PDE6B	Phosphodiesterase 6B	0.7545	46
ADD1	Adducin 1	0.7501	46
NR2E3	Nuclear receptor subfamily 2 group E member 3	0.7499	46
ZMYND19	Zinc finger MYND-type containing 19	0.7423	46
OR5P2	Olfactory receptor family 5 subfamily P member 2	0.7396	46
EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit	0.7361	46
OR5P3	Olfactory receptor family 5 subfamily P member 3	0.7336	46
SPINT4	Serine peptidase inhibitor, Kunitz type 4	0.7324	46
RDH8	Retinol dehydrogenase 8	0.7313	46
CNGB1	Cyclic nucleotide gated channel subunit beta 1	0.7257	46
MOK	MOK protein kinase	0.7244	46
OVCH2	Ovochymase 2	0.7240	46

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	132.5 nTPM
Adipose tissue	162.0 nTPM
Breast	103.0 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	12.0 nTPM
Lung	12.0 nTPM

Astrocytes	150.5 nTPM
Brain	150.5 nTPM

B-cells	17.0 nTPM
Colon	27.1 nTPM
Adipose tissue	26.6 nTPM
PBMC	24.3 nTPM
Kidney	23.8 nTPM
Spleen	14.9 nTPM
Breast	14.7 nTPM
Bone marrow	11.5 nTPM
Liver	11.4 nTPM
Lymph node	10.7 nTPM
Stomach	5.0 nTPM

Dendritic cells	4.8 nTPM
Adipose tissue	6.1 nTPM
Breast	4.3 nTPM
PBMC	4.0 nTPM

Endothelial cells	92.9 nTPM
Skeletal muscle	318.0 nTPM
Heart muscle	239.7 nTPM
Lung	177.8 nTPM
Eye	152.1 nTPM
Breast	55.5 nTPM
Ovary	53.2 nTPM
Pancreas	50.2 nTPM
Endometrium	44.5 nTPM
Placenta	43.8 nTPM
Skin	41.4 nTPM
Liver	40.3 nTPM
Prostate	33.8 nTPM
Testis	31.4 nTPM
Esophagus	18.9 nTPM

Fibroblasts	120.5 nTPM
Skeletal muscle	242.1 nTPM
Adipose tissue	194.3 nTPM
Heart muscle	174.3 nTPM
Stomach	109.9 nTPM
Esophagus	108.2 nTPM
Breast	98.6 nTPM
Placenta	94.1 nTPM
Lung	92.8 nTPM
Skin	76.6 nTPM
Ovary	68.6 nTPM
Prostate	65.6 nTPM

Intestinal goblet cells	41.9 nTPM
Colon	55.0 nTPM
Small intestine	44.0 nTPM
Rectum	26.7 nTPM

Macrophages	50.8 nTPM
Breast	96.8 nTPM
Ovary	93.4 nTPM
Testis	91.8 nTPM
Prostate	91.7 nTPM
Endometrium	75.9 nTPM
Adipose tissue	68.4 nTPM
Skeletal muscle	50.5 nTPM
Spleen	46.7 nTPM
Esophagus	44.1 nTPM
Lung	43.3 nTPM
Kidney	24.2 nTPM
Pancreas	17.8 nTPM
Bone marrow	11.3 nTPM
Stomach	5.9 nTPM
PBMC	0.0 nTPM

Paneth cells	25.0 nTPM
Colon	36.2 nTPM
Small intestine	22.5 nTPM
Rectum	16.4 nTPM

Plasma cells	10.2 nTPM
Esophagus	24.6 nTPM
Adipose tissue	9.7 nTPM
Spleen	7.8 nTPM
Stomach	5.7 nTPM
Bone marrow	3.3 nTPM

Respiratory ciliated cells	11.2 nTPM
Lung	21.9 nTPM
Bronchus	0.6 nTPM

Smooth muscle cells	89.2 nTPM
Skeletal muscle	184.7 nTPM
Adipose tissue	175.7 nTPM
Heart muscle	172.0 nTPM
Endometrium	101.8 nTPM
Ovary	81.0 nTPM
Breast	80.9 nTPM
Prostate	63.8 nTPM
Skin	46.4 nTPM
Esophagus	41.9 nTPM
Pancreas	32.5 nTPM
Bronchus	0.0 nTPM

T-cells	9.4 nTPM
Endometrium	41.3 nTPM
Lung	16.7 nTPM
Skeletal muscle	16.2 nTPM
Prostate	14.2 nTPM
Colon	13.3 nTPM
Esophagus	13.1 nTPM
Skin	11.1 nTPM
Adipose tissue	7.6 nTPM
Breast	6.5 nTPM
Liver	4.3 nTPM
Lymph node	4.3 nTPM
PBMC	3.3 nTPM
Spleen	3.1 nTPM
Stomach	2.6 nTPM
Kidney	2.0 nTPM
Bone marrow	1.1 nTPM
Ovary	0.0 nTPM

Basal keratinocytes	15.4 nTPM
Skin	15.4 nTPM

Basal respiratory cells	5.3 nTPM
Bronchus	5.3 nTPM

Basal squamous epithelial cells	24.5 nTPM
Esophagus	24.5 nTPM

Cholangiocytes	21.5 nTPM
Liver	21.5 nTPM

Undifferentiated cells	39.3 nTPM
Colon	56.4 nTPM
Small intestine	45.6 nTPM
Rectum	15.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC