Single cell type - KEAP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KEAP1
Gene descriptionⁱ Full gene name according to HGNC.	Kelch like ECH associated protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes FDA approved drug targets Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

KEAP1 is part of cluster 25 Spermatids - Spermatogenesis with confidenceⁱ 1
458 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ACTR1A	Actin related protein 1A	0.4386	1
SZRD1	SUZ RNA binding domain containing 1	0.4383	3
CTDSP2	CTD small phosphatase 2	0.4346	53
DCTN2	Dynactin subunit 2	0.4318	31
MAD2L2	Mitotic arrest deficient 2 like 2	0.4280	25
AIFM2	Apoptosis inducing factor mitochondria associated 2	0.4257	53
MRPL28	Mitochondrial ribosomal protein L28	0.4237	31
PIN1	Peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.4124	31
MFSD14A	Major facilitator superfamily domain containing 14A	0.4123	25
HPS6	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3	0.4084	47
EIF4G1	Eukaryotic translation initiation factor 4 gamma 1	0.4082	53
CLPTM1	CLPTM1 regulator of GABA type A receptor forward trafficking	0.4053	55
ADORA2A	Adenosine A2a receptor	0.3989	58
NABP2	Nucleic acid binding protein 2	0.3944	25
FBXW5	F-box and WD repeat domain containing 5	0.3938	25

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	18.3 nTPM
Breast	21.0 nTPM
Adipose tissue	15.6 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	20.8 nTPM
Lung	20.8 nTPM

Astrocytes	5.5 nTPM
Brain	5.5 nTPM

B-cells	13.8 nTPM
Liver	29.4 nTPM
Stomach	18.6 nTPM
Bone marrow	17.2 nTPM
Lymph node	16.5 nTPM
Spleen	15.3 nTPM
Kidney	14.3 nTPM
Breast	9.4 nTPM
Colon	8.0 nTPM
PBMC	5.7 nTPM
Adipose tissue	4.0 nTPM

Dendritic cells	11.6 nTPM
Adipose tissue	15.7 nTPM
Breast	11.3 nTPM
PBMC	8.0 nTPM

Endothelial cells	27.8 nTPM
Prostate	46.7 nTPM
Pancreas	46.4 nTPM
Placenta	34.7 nTPM
Ovary	32.0 nTPM
Esophagus	31.5 nTPM
Liver	31.2 nTPM
Testis	26.6 nTPM
Eye	25.9 nTPM
Heart muscle	22.4 nTPM
Breast	21.1 nTPM
Skeletal muscle	20.7 nTPM
Endometrium	20.0 nTPM
Skin	17.0 nTPM
Lung	12.5 nTPM

Fibroblasts	23.5 nTPM
Placenta	30.3 nTPM
Prostate	29.7 nTPM
Ovary	27.5 nTPM
Esophagus	25.7 nTPM
Skeletal muscle	25.5 nTPM
Stomach	25.3 nTPM
Adipose tissue	20.5 nTPM
Breast	19.2 nTPM
Skin	19.0 nTPM
Heart muscle	18.2 nTPM
Lung	17.9 nTPM

Intestinal goblet cells	21.4 nTPM
Small intestine	26.5 nTPM
Rectum	21.9 nTPM
Colon	15.7 nTPM

Macrophages	16.1 nTPM
Pancreas	33.2 nTPM
Ovary	21.2 nTPM
Prostate	20.7 nTPM
Kidney	18.9 nTPM
Esophagus	18.9 nTPM
Stomach	17.6 nTPM
Lung	16.3 nTPM
Testis	14.0 nTPM
PBMC	13.6 nTPM
Skeletal muscle	12.9 nTPM
Bone marrow	12.5 nTPM
Spleen	12.5 nTPM
Breast	10.6 nTPM
Endometrium	9.9 nTPM
Adipose tissue	8.6 nTPM

Paneth cells	27.1 nTPM
Small intestine	45.0 nTPM
Rectum	23.2 nTPM
Colon	13.2 nTPM

Plasma cells	26.6 nTPM
Spleen	47.2 nTPM
Bone marrow	33.0 nTPM
Stomach	30.0 nTPM
Esophagus	12.3 nTPM
Adipose tissue	10.3 nTPM

Respiratory ciliated cells	17.2 nTPM
Bronchus	19.9 nTPM
Lung	14.6 nTPM

Smooth muscle cells	22.4 nTPM
Pancreas	49.0 nTPM
Ovary	31.3 nTPM
Esophagus	29.4 nTPM
Prostate	23.7 nTPM
Bronchus	23.6 nTPM
Breast	20.0 nTPM
Skeletal muscle	17.3 nTPM
Skin	16.4 nTPM
Endometrium	15.7 nTPM
Adipose tissue	12.7 nTPM
Heart muscle	7.2 nTPM

T-cells	20.1 nTPM
Bone marrow	32.5 nTPM
Ovary	31.1 nTPM
Spleen	29.7 nTPM
Kidney	28.7 nTPM
Lymph node	27.2 nTPM
Liver	26.2 nTPM
Esophagus	26.2 nTPM
Stomach	26.2 nTPM
Colon	20.9 nTPM
Lung	15.2 nTPM
Skeletal muscle	13.9 nTPM
PBMC	13.7 nTPM
Skin	13.3 nTPM
Endometrium	12.0 nTPM
Breast	10.2 nTPM
Adipose tissue	9.5 nTPM
Prostate	4.7 nTPM

Basal prostatic cells	24.4 nTPM
Prostate	24.4 nTPM

Basal respiratory cells	40.3 nTPM
Bronchus	40.3 nTPM

Basal squamous epithelial cells	27.9 nTPM
Esophagus	27.9 nTPM

Cholangiocytes	21.5 nTPM
Liver	21.5 nTPM

Undifferentiated cells	31.5 nTPM
Colon	33.4 nTPM
Small intestine	31.0 nTPM
Rectum	30.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC