Single cell type - SMARCA2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SMARCA2
Gene descriptionⁱ Full gene name according to HGNC.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	42

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Inhibitory neurons, Astrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enriched (HDLM-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Inhibitory neurons, Astrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SMARCA2 is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 1
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
VAV3	Vav guanine nucleotide exchange factor 3	0.5039	18
ZBTB1	Zinc finger and BTB domain containing 1	0.4900	24
TRERF1	Transcriptional regulating factor 1	0.4833	8
GABRB1	Gamma-aminobutyric acid type A receptor subunit beta1	0.4812	64
PHF20L1	PHD finger protein 20 like 1	0.4739	51
CEMIP2	Cell migration inducing hyaluronidase 2	0.4713	24
CRYBG1	Crystallin beta-gamma domain containing 1	0.4679	24
NCOA2	Nuclear receptor coactivator 2	0.4653	8
RGPD2	RANBP2 like and GRIP domain containing 2	0.4607	24
TENM2	Teneurin transmembrane protein 2	0.4606	8
ARL4C	ADP ribosylation factor like GTPase 4C	0.4548	24
MSL2	MSL complex subunit 2	0.4472	24
NR3C2	Nuclear receptor subfamily 3 group C member 2	0.4453	8
PPP2R5C	Protein phosphatase 2 regulatory subunit B'gamma	0.4442	24
KANTR	KDM5C adjacent transcript	0.4406	7

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	83.9 nTPM
Adipose tissue	104.8 nTPM
Breast	63.0 nTPM

Alveolar cells type 1	73.7 nTPM
Lung	73.7 nTPM

Alveolar cells type 2	70.6 nTPM
Lung	70.6 nTPM

B-cells	57.2 nTPM
Adipose tissue	103.7 nTPM
Lymph node	83.8 nTPM
Breast	73.5 nTPM
Stomach	67.3 nTPM
Spleen	59.1 nTPM
Bone marrow	54.0 nTPM
PBMC	47.1 nTPM
Liver	32.9 nTPM
Kidney	28.5 nTPM
Colon	22.3 nTPM

Basal keratinocytes	58.6 nTPM
Skin	58.6 nTPM

Dendritic cells	102.8 nTPM
Adipose tissue	184.1 nTPM
Breast	84.5 nTPM
PBMC	39.8 nTPM

Endothelial cells	69.0 nTPM
Heart muscle	149.7 nTPM
Lung	121.6 nTPM
Testis	80.6 nTPM
Endometrium	80.4 nTPM
Ovary	72.3 nTPM
Breast	71.6 nTPM
Skeletal muscle	71.5 nTPM
Esophagus	67.5 nTPM
Skin	66.3 nTPM
Eye	51.0 nTPM
Liver	48.6 nTPM
Prostate	37.7 nTPM
Placenta	31.8 nTPM
Pancreas	15.5 nTPM

Fibroblasts	65.7 nTPM
Esophagus	128.3 nTPM
Heart muscle	100.3 nTPM
Breast	77.7 nTPM
Adipose tissue	72.2 nTPM
Skin	70.2 nTPM
Skeletal muscle	65.5 nTPM
Stomach	62.4 nTPM
Ovary	47.3 nTPM
Lung	45.8 nTPM
Prostate	29.6 nTPM
Placenta	23.4 nTPM

Intestinal goblet cells	31.2 nTPM
Rectum	36.5 nTPM
Small intestine	33.6 nTPM
Colon	23.5 nTPM

Macrophages	57.5 nTPM
Adipose tissue	143.6 nTPM
Lung	81.4 nTPM
Breast	75.3 nTPM
PBMC	68.2 nTPM
Bone marrow	62.5 nTPM
Skeletal muscle	57.1 nTPM
Spleen	52.9 nTPM
Ovary	51.8 nTPM
Testis	48.7 nTPM
Endometrium	46.1 nTPM
Esophagus	45.6 nTPM
Kidney	40.1 nTPM
Stomach	35.1 nTPM
Prostate	28.7 nTPM
Pancreas	25.5 nTPM

Paneth cells	15.1 nTPM
Rectum	31.2 nTPM
Small intestine	7.5 nTPM
Colon	6.5 nTPM

Plasma cells	71.4 nTPM
Adipose tissue	190.3 nTPM
Bone marrow	54.4 nTPM
Spleen	52.0 nTPM
Stomach	47.9 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	88.3 nTPM
Lung	116.6 nTPM
Bronchus	60.1 nTPM

Smooth muscle cells	40.3 nTPM
Esophagus	72.9 nTPM
Heart muscle	64.3 nTPM
Bronchus	59.8 nTPM
Adipose tissue	46.0 nTPM
Breast	41.6 nTPM
Endometrium	38.2 nTPM
Skin	31.7 nTPM
Skeletal muscle	27.2 nTPM
Ovary	27.0 nTPM
Prostate	17.5 nTPM
Pancreas	16.9 nTPM

T-cells	74.8 nTPM
Adipose tissue	172.6 nTPM
Breast	116.8 nTPM
Endometrium	113.8 nTPM
Lymph node	98.9 nTPM
Stomach	91.5 nTPM
Bone marrow	89.7 nTPM
Spleen	82.7 nTPM
Skeletal muscle	76.6 nTPM
Ovary	75.7 nTPM
Lung	63.8 nTPM
Liver	61.3 nTPM
Skin	52.0 nTPM
Kidney	50.7 nTPM
PBMC	45.3 nTPM
Colon	35.6 nTPM
Esophagus	26.2 nTPM
Prostate	19.0 nTPM

Astrocytes	246.5 nTPM
Brain	246.5 nTPM

Cholangiocytes	31.5 nTPM
Liver	31.5 nTPM

Collecting duct cells	106.7 nTPM
Kidney	106.7 nTPM

Cone photoreceptor cells	37.5 nTPM
Eye	37.5 nTPM

Undifferentiated cells	28.2 nTPM
Rectum	31.6 nTPM
Small intestine	30.4 nTPM
Colon	22.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC