Single cell type - SRCAP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SRCAP
Gene descriptionⁱ Full gene name according to HGNC.	Snf2 related CREBBP activator protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Respiratory epithelial cells - Mucosal defense (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal respiratory cells, Ionocytes, Club cells, Respiratory ciliated cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal respiratory cells, Ionocytes, Club cells, Respiratory ciliated cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SRCAP is part of cluster 26 Respiratory epithelial cells - Mucosal defense with confidenceⁱ 1
293 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SLPI	Secretory leukocyte peptidase inhibitor	0.9388	26
LYPD2	LY6/PLAUR domain containing 2	0.9309	26
BIK	BCL2 interacting killer	0.9309	26
BPIFB1	BPI fold containing family B member 1	0.9231	26
BPIFA1	BPI fold containing family A member 1	0.9229	26
SERPINB3	Serpin family B member 3	0.9195	26
ATP12A	ATPase H+/K+ transporting non-gastric alpha2 subunit	0.9182	26
PI3	Peptidase inhibitor 3	0.9154	26
PGLYRP4	Peptidoglycan recognition protein 4	0.9148	26
BPIFA2	BPI fold containing family A member 2	0.9111	26
VNN3	Vanin 3	0.9077	26
CYP2F1	Cytochrome P450 family 2 subfamily F member 1	0.9032	26
TMEM45A	Transmembrane protein 45A	0.8994	26
IL17C	Interleukin 17C	0.8937	26
SCGB3A1	Secretoglobin family 3A member 1	0.8923	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	3.0 nTPM
Adipose tissue	3.5 nTPM
Breast	2.5 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	3.7 nTPM
Lung	3.7 nTPM

Astrocytes	8.8 nTPM
Brain	8.8 nTPM

B-cells	9.8 nTPM
Colon	27.1 nTPM
Stomach	17.2 nTPM
Lymph node	15.3 nTPM
Bone marrow	12.3 nTPM
Spleen	11.8 nTPM
Adipose tissue	7.5 nTPM
Breast	4.0 nTPM
Liver	3.3 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM

Dendritic cells	5.3 nTPM
Adipose tissue	8.1 nTPM
PBMC	4.0 nTPM
Breast	3.6 nTPM

Endothelial cells	3.4 nTPM
Skin	14.5 nTPM
Prostate	4.9 nTPM
Endometrium	4.6 nTPM
Esophagus	3.7 nTPM
Heart muscle	3.4 nTPM
Skeletal muscle	3.2 nTPM
Lung	3.1 nTPM
Ovary	3.0 nTPM
Breast	2.4 nTPM
Testis	1.8 nTPM
Placenta	1.1 nTPM
Liver	0.9 nTPM
Eye	0.8 nTPM
Pancreas	0.0 nTPM

Fibroblasts	4.2 nTPM
Skin	15.2 nTPM
Esophagus	7.1 nTPM
Stomach	6.0 nTPM
Skeletal muscle	4.8 nTPM
Prostate	3.4 nTPM
Ovary	2.7 nTPM
Adipose tissue	2.0 nTPM
Breast	1.9 nTPM
Lung	1.2 nTPM
Heart muscle	1.1 nTPM
Placenta	1.1 nTPM

Intestinal goblet cells	17.7 nTPM
Colon	46.5 nTPM
Small intestine	3.8 nTPM
Rectum	2.9 nTPM

Macrophages	3.4 nTPM
Adipose tissue	9.8 nTPM
Spleen	8.3 nTPM
Esophagus	6.3 nTPM
Kidney	4.6 nTPM
Skeletal muscle	4.6 nTPM
Endometrium	4.1 nTPM
Bone marrow	3.7 nTPM
Breast	3.4 nTPM
Prostate	2.2 nTPM
Ovary	2.1 nTPM
Lung	1.4 nTPM
Testis	0.6 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	39.1 nTPM
Colon	115.3 nTPM
Rectum	1.9 nTPM
Small intestine	0.0 nTPM

Plasma cells	11.1 nTPM
Stomach	13.3 nTPM
Bone marrow	13.2 nTPM
Esophagus	12.3 nTPM
Spleen	12.0 nTPM
Adipose tissue	4.5 nTPM

Respiratory ciliated cells	118.3 nTPM
Bronchus	236.5 nTPM
Lung	0.0 nTPM

Smooth muscle cells	14.3 nTPM
Bronchus	112.9 nTPM
Skin	17.5 nTPM
Esophagus	6.2 nTPM
Endometrium	4.6 nTPM
Prostate	4.3 nTPM
Skeletal muscle	3.4 nTPM
Adipose tissue	3.1 nTPM
Breast	2.7 nTPM
Ovary	1.3 nTPM
Heart muscle	0.6 nTPM
Pancreas	0.6 nTPM

T-cells	8.9 nTPM
Colon	32.8 nTPM
Esophagus	19.7 nTPM
Spleen	13.1 nTPM
Lymph node	13.0 nTPM
Skin	11.9 nTPM
Stomach	10.9 nTPM
Bone marrow	9.1 nTPM
Adipose tissue	7.8 nTPM
Skeletal muscle	6.5 nTPM
Endometrium	5.4 nTPM
Lung	4.5 nTPM
Ovary	4.5 nTPM
Breast	4.2 nTPM
Kidney	3.4 nTPM
Liver	3.1 nTPM
PBMC	1.4 nTPM
Prostate	0.0 nTPM

Basal keratinocytes	24.6 nTPM
Skin	24.6 nTPM

Cone photoreceptor cells	8.4 nTPM
Eye	8.4 nTPM

Cytotrophoblasts	2.3 nTPM
Placenta	2.3 nTPM

Distal enterocytes	54.3 nTPM
Colon	105.9 nTPM
Rectum	2.8 nTPM

Undifferentiated cells	25.6 nTPM
Colon	71.0 nTPM
Rectum	2.9 nTPM
Small intestine	2.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC