Single cell type - STK17B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	STK17B
Gene descriptionⁱ Full gene name according to HGNC.	Serine/threonine kinase 17b
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (T-cells, dendritic cells, B-cells, Langerhans cells, Macrophages, granulocytes, Plasma cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Daudi, HMC-1, Karpas-707, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (T-cells, dendritic cells, B-cells, Langerhans cells, Macrophages, granulocytes, Plasma cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

STK17B is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 1
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZC3H12D	Zinc finger CCCH-type containing 12D	0.8412	24
STK4	Serine/threonine kinase 4	0.7754	24
ELF1	E74 like ETS transcription factor 1	0.7740	24
CXCR4	C-X-C motif chemokine receptor 4	0.7672	24
CTLA4	Cytotoxic T-lymphocyte associated protein 4	0.7538	24
PMCH	Pro-melanin concentrating hormone	0.7516	24
CASS4	Cas scaffold protein family member 4	0.7479	24
CCR4	C-C motif chemokine receptor 4	0.7451	24
CCR6	C-C motif chemokine receptor 6	0.7427	24
CCR8	C-C motif chemokine receptor 8	0.7419	24
SMAP2	Small ArfGAP2	0.7351	24
BICDL1	BICD family like cargo adaptor 1	0.7210	24
PTGER4	Prostaglandin E receptor 4	0.7169	24
TNFSF8	TNF superfamily member 8	0.7121	24
SMCHD1	Structural maintenance of chromosomes flexible hinge domain containing 1	0.7120	24

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	23.3 nTPM
Adipose tissue	29.7 nTPM
Breast	16.9 nTPM

Alveolar cells type 1	89.8 nTPM
Lung	89.8 nTPM

Alveolar cells type 2	74.0 nTPM
Lung	74.0 nTPM

Astrocytes	48.3 nTPM
Brain	48.3 nTPM

Basal keratinocytes	59.9 nTPM
Skin	59.9 nTPM

B-cells	229.3 nTPM
Adipose tissue	428.1 nTPM
Stomach	385.1 nTPM
Lymph node	336.7 nTPM
Bone marrow	214.2 nTPM
Spleen	195.9 nTPM
Colon	186.9 nTPM
PBMC	159.9 nTPM
Kidney	152.4 nTPM
Liver	123.2 nTPM
Breast	111.1 nTPM

Dendritic cells	267.7 nTPM
Adipose tissue	482.4 nTPM
Breast	205.2 nTPM
PBMC	115.6 nTPM

Endothelial cells	11.3 nTPM
Skin	31.7 nTPM
Eye	21.8 nTPM
Skeletal muscle	18.0 nTPM
Heart muscle	16.4 nTPM
Breast	13.6 nTPM
Lung	12.5 nTPM
Ovary	8.9 nTPM
Prostate	7.8 nTPM
Endometrium	7.6 nTPM
Testis	7.1 nTPM
Liver	5.5 nTPM
Pancreas	3.9 nTPM
Esophagus	3.1 nTPM
Placenta	1.1 nTPM

Fibroblasts	27.2 nTPM
Skin	67.5 nTPM
Adipose tissue	67.1 nTPM
Breast	31.4 nTPM
Stomach	28.2 nTPM
Prostate	24.9 nTPM
Skeletal muscle	24.9 nTPM
Lung	22.4 nTPM
Esophagus	13.4 nTPM
Placenta	7.7 nTPM
Heart muscle	5.9 nTPM
Ovary	5.9 nTPM

Intestinal goblet cells	13.9 nTPM
Colon	17.2 nTPM
Small intestine	14.0 nTPM
Rectum	10.4 nTPM

Macrophages	198.9 nTPM
Adipose tissue	617.6 nTPM
Stomach	369.2 nTPM
Skeletal muscle	318.1 nTPM
Spleen	263.3 nTPM
Testis	220.1 nTPM
Esophagus	190.4 nTPM
Lung	178.5 nTPM
Kidney	158.8 nTPM
Bone marrow	157.4 nTPM
Endometrium	137.7 nTPM
Breast	137.4 nTPM
Prostate	97.4 nTPM
Ovary	83.5 nTPM
Pancreas	40.8 nTPM
PBMC	13.6 nTPM

Paneth cells	41.6 nTPM
Colon	59.3 nTPM
Small intestine	41.3 nTPM
Rectum	24.1 nTPM

Plasma cells	191.8 nTPM
Stomach	290.2 nTPM
Adipose tissue	274.1 nTPM
Esophagus	135.4 nTPM
Spleen	132.3 nTPM
Bone marrow	126.9 nTPM

Respiratory ciliated cells	26.9 nTPM
Lung	37.9 nTPM
Bronchus	15.9 nTPM

Smooth muscle cells	19.7 nTPM
Ovary	63.9 nTPM
Adipose tissue	33.2 nTPM
Skin	27.6 nTPM
Pancreas	23.8 nTPM
Breast	14.3 nTPM
Endometrium	11.9 nTPM
Skeletal muscle	10.6 nTPM
Esophagus	9.3 nTPM
Prostate	9.1 nTPM
Heart muscle	7.0 nTPM
Bronchus	6.5 nTPM

Cholangiocytes	12.8 nTPM
Liver	12.8 nTPM

Collecting duct cells	11.0 nTPM
Kidney	11.0 nTPM

Cone photoreceptor cells	0.0 nTPM
Eye	0.0 nTPM

Cytotrophoblasts	7.9 nTPM
Placenta	7.9 nTPM

T-cells	342.5 nTPM
Adipose tissue	862.3 nTPM
Skin	691.6 nTPM
Lymph node	444.0 nTPM
Stomach	433.0 nTPM
Endometrium	388.1 nTPM
Skeletal muscle	367.1 nTPM
Breast	366.6 nTPM
Colon	335.5 nTPM
Esophagus	314.4 nTPM
Spleen	290.0 nTPM
Ovary	235.8 nTPM
PBMC	206.7 nTPM
Lung	205.0 nTPM
Liver	193.0 nTPM
Kidney	191.6 nTPM
Bone marrow	189.2 nTPM
Prostate	108.9 nTPM

Undifferentiated cells	13.2 nTPM
Colon	20.7 nTPM
Small intestine	9.9 nTPM
Rectum	9.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC